15900547 420 KMTDTGNVTRTAAHEDAIAVASAKNQTVEFDKVNIGGESFKYRNiGAFFDKSKITTNEDGTKAPSKLKFVYIGKGQDqdL 499 Streptococcus pne... 15792688 10 VCKLFALSEFELHHIDKVHKLGYSGDTIIIGVADDAFNQDHISLkDKILKSTYPTDTAGKQLIPDLKKSTHGSHVAGiaV 89 Campylobacter jejuni 19704758 2 DSQKGNISALKEKLNRNRENSTATIPTETISYNGSTVKIGILDS-DFTDPVRKAQLSARYP--------GIEFIPRV--N 70 Fusobacterium nuc... 19705252 2 DETK-----VREFIFNEQNNSIENIPMDNRVLNGDKVKVGVLDG-DFIN--KKNYLENKYG--------NIEILER---N 62 Fusobacterium nuc... 15793479 99 PNLHTG---DFTNPNDAYKNLINLKPAIEAGYTGRGVEVGIVDT-GESVGSISFPELYGRKEHGYNENYKNYTAYMR--K 172 Neisseria meningi... 15677799 99 PNLHTG---DFPNPNDAYKNLINLKPAIEAGYTGRGVEVGIVDT-GESVGSISFPELYGRKEHGYNENYKNYTAYMR--K 172 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 2 PALDP----ALAAKFRVHLDGTNTEPAHTLGFTGKGYMIGVVDS-GVNRNHVTLHDKVVHN--------NVYVDYQD--P 66 Xylella fastidios... 15837628 2 PTLDP----SLAAKFRVHLDGTNTEPARTLGFTGKGYMIGVVDS-GVNRNHVTLHNQVIHN--------NVYVDYQD--P 66 Xylella fastidios... 15838449 92 PSLPP----SLAAKIGRHLELTNTEAAHALGLTGSGFIIGMVDT-GVHRNNIALQGKVIRSGV-----YNFYTDYHA--P 159 Xylella fastidios...
15900547 500 IGLDLRGkiavmdriytkdlknafkkamdkgaraimvVNTVNYYNRDNWTELpaMGYEADEGtkSQVFSISGDDGVKLWN 579 Streptococcus pne... 15792688 90 GAKIGDS------------------------------KPYGVAYGAKFYGAGvfPNGSYTQIpdIYNFFKDVSIINNSWG 139 Campylobacter jejuni 19704758 71 SDTSTSS------------------------------HGVQVLEVMMDTLED--RTK-GKAK--FKAIAASIGNGG--AS 113 Fusobacterium nuc... 19705252 63 YNPKHSN------------------------------HGELVLKVLRE-----------KNK--LGIIAGSIGENDDFSG 99 Fusobacterium nuc... 15793479 173 EAPEDGDgkdieasfddeavieteakptdirhvkeigHIDVVSHIIGGRSVD--GRPAGGIA--PDATLHIMNTHD--GT 246 Neisseria meningi... 15677799 173 EAPEDGGgkdieasfddeavieteakptdirhvkeigHIDLVSHIIGGRSVD--GRPAGGIA--PDATLHIMNTND--ET 246 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 67 ASPDDVSg-----------------------------HGTNVAQLIAGQPVE--YWP-GGIA--PGATIFSARVFS--SA 110 Xylella fastidios... 15837628 67 ASSDDVSg-----------------------------HGTNVAQLIAGQPVE--YWP-GGIA--PGATIFSARVFS--SA 110 Xylella fastidios... 15838449 160 SAPDDVDn-----------------------------HGTLVAQLIAGQPVE--HWP-GGIA--PGASIFSARVYP--SE 203 Xylella fastidios...
15900547 580 MINPDKKTEVKRNnkedfkdkleqyypidmesfnsnkpnvgdekeidfkfapdtdkelykediivpagstswgpridlll 659 Streptococcus pne... 15792688 140 INFYPYFNLKASNsgl---------------------------------------------------------------v 156 Campylobacter jejuni 19704758 114 ETNKSVNPNVKTYekvf-------------------------------------------------------------er 132 Fusobacterium nuc... 19705252 100 KEGTTVIPKLETYekvl-------------------------------------------------------------ek 118 Fusobacterium nuc... 15793479 247 KNEIMSAAIRNAWvklgerg------------------------------------------------------vrivnn 272 Neisseria meningi... 15677799 247 KNEMMVAAIRNAWvklgerg------------------------------------------------------vrivnn 272 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 111 AENAK--QGPIGGnff---------------------------------------------------------------e 125 Xylella fastidios... 15837628 111 AESAK--EGSISGnff---------------------------------------------------------------e 125 Xylella fastidios... 15838449 204 EEFEAYIEEQMTSshivd-----------------------------------------------------------tfe 224 Xylella fastidios...
15900547 660 kPDVSAPGKNIKSTLNVINGKSTYGYMSGTSMatpivaastvlirpklkemleRPVLKNLKGDdkidltsltkialqnta 739 Streptococcus pne... 15792688 157 dCTQTNQGTSYNICNTPLEYVMKADKVANDMMr--------------------LSKDKGVLN------------------ 198 Campylobacter jejuni 19704758 133 fNFNQKVKVVNQSFGADITIEEAPYTKNNIRN---------------------YVWAGd--------------------- 170 Fusobacterium nuc... 19705252 119 fNPNQKVKVFSQSWGVPETIGSYISKSEEERM---------------------RAIAPGQTSSe---------------- 161 Fusobacterium nuc... 15793479 273 sFGTTSRAGTADHFQIANSEEQYRQALLAYSG---------------------GDKTDEGIRLm---------------- 315 Neisseria meningi... 15677799 273 sFGTTSRAGTADLFQIANSEEQYRQALLDYSG---------------------GDKTDEGIRLm---------------- 315 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 126 gEAAQLKRVNADMIAAGVRIQNNSWGYENQNT---------------------GDKQVWIDPAv---------------- 168 Xylella fastidios... 15837628 126 rETAQLKRVNADMIAAGVRIQNNSWGYESEDT---------------------GGEPVWRSPIt---------------- 168 Xylella fastidios... 15838449 225 aEASKIRLINADMIAAGVRIQNNSWGHSS--------------------------YAMWTDPKi---------------- 262 Xylella fastidios...
15900547 740 rpmmdatswkeksqyfasprqqgaglinvanalrnevvatfkntdskglvnsygsislkeikgdkKYFTIKLHNTSNRPL 819 Streptococcus pne... 15792688 199 ------------------------------------------------------------------VFAAGNEGILSPAL 212 Campylobacter jejuni 19704758 171 -----------------------------------------------------------------SKPFATYFEEKVNND 185 Fusobacterium nuc... 19705252 162 -----------------------------------------------------------------GRKILDFYKKEVNKD 176 Fusobacterium nuc... 15793479 316 -----------------------------------------------------------------QQSDYGNLSYHIRNK 330 Neisseria meningi... 15677799 316 -----------------------------------------------------------------QQSDYGNLSYHIRNK 330 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 169 -----------------------------------------------------------------TDAFVNVYRDFVLNN 183 Xylella fastidios... 15837628 169 -----------------------------------------------------------------TGLFVNAYRDFVLNN 183 Xylella fastidios... 15838449 263 -----------------------------------------------------------------TNLFGDTYRDFVIGS 277 Xylella fastidios...
15900547 820 TFKVSasaittdsltdrlkldetykdekspdgkqivpeihpekvkganitfehdtftiganssfdlnavinvgeaknknk 899 Streptococcus pne... 15792688 213 HAILPs-------------------------------------------------------------------------- 218 Campylobacter jejuni 19704758 186 GGLFV--------------------------------------------------------------------------- 190 Fusobacterium nuc... 19705252 177 T-LFI--------------------------------------------------------------------------- 180 Fusobacterium nuc... 15793479 331 NMLFI--------------------------------------------------------------------------- 335 Neisseria meningi... 15677799 331 NMLFI--------------------------------------------------------------------------- 335 Neisseria meningi... 1170704 -------------------------------------------------------------------------------- fission yeast 15836872 184 NGLVI--------------------------------------------------------------------------- 188 Xylella fastidios... 15837628 184 NGLVV--------------------------------------------------------------------------- 188 Xylella fastidios... 15838449 278 NGLVV--------------------------------------------------------------------------- 282 Xylella fastidios...
15900547 900 fvesfihFESVEEMEALNSNgkkinfQPSLSMPLMGFAGnwnhepildkwaweeGSRSKTLGgydddgKPKIPGTLNKGI 979 Streptococcus pne... 15792688 219 -------YDESLRAWLAVGAl----dANEITLESDGTLIi--------------KSQGLADF------SNGFKGATNFSl 267 Campylobacter jejuni 19704758 191 -------WAAGNRKGATETN------PGQDMDSVGM-EA---------------GLPYLVND------LEKGWIAVVGIQ 235 Fusobacterium nuc... 19705252 181 -------WANGN-TLVNNQN------QVVLFNDAYY-QG---------------GLPHLYSE------LEKGWITVVGVK 224 Fusobacterium nuc... 15793479 336 -------FSASN-DAQAQPN------TLTLLPFYEKDAQ---------------KGIITVAG------VDRSGEKFN--- 377 Neisseria meningi... 15677799 336 -------FSTGN-DAQAQPN------TYALLPFYEKDAQ---------------KGIITVAG------VDRSGEKFKREM 380 Neisseria meningi... 1170704 1 --------MHPALLCGPILAi-----FLQFLVSSCSPLEn--------------DDLFLVQVep---eVDPVVAAEAIGA 50 fission yeast 15836872 189 -------FASGN-YSQQQPG------RLSRLPSLPT-VE---------------GGASPAD-------LERGWLVVAALD 231 Xylella fastidios... 15837628 189 -------FASGN-EAQPQPG------QLARLPSLPT-VE---------------GGASPAD-------LERGWLVVAALD 231 Xylella fastidios... 15838449 283 -------FSTGN-EKLSQPN------GLARLPSLLR-AE---------------GSPSAADD------LERGWLAVAGLD 326 Xylella fastidios...
15900547 980 ggehgidkfnpagviqnrkdknttsldqnpelfafNNEGINAPsssgskIANIypldsngnpqDAQLERGLTPSPLVLRS 1059 Streptococcus pne... 15792688 268 -----------------------------------VAAGVNINn-----VDSSt----------nDKFTKKSGTSMAAPM 297 Campylobacter jejuni 19704758 236 pketv--------------------------rvgtAPDGTPIV------NIKPng-------kLNIHRTGTDRLAYAGD- 275 Fusobacterium nuc... 19705252 225 k-----------------------------------kDG-----------Nm-----------LNKHYTDTAHLAYPG-- 245 Fusobacterium nuc... 15793479 378 ---------------------------------------------------------------GSNHCGITAMWCLSAP- 393 Neisseria meningi... 15677799 381 yge-------------------------------pgtEPLe---------------------yGSNHCGITAMWCLSAP- 407 Neisseria meningi... 1170704 51 kyvrpllnlk---------------yhhliklhkgSDDSVQSS------IRKRgid-----agILELERQTPRWRYKRDA 104 fission yeast 15836872 232 sfd--------------------------------hpDQLt---------------------sYSNHCGIAMHYCLAAPG 258 Xylella fastidios... 15837628 232 sfd--------------------------------hpDQLt---------------------sYSNHCGIAMHYCLAAPG 258 Xylella fastidios... 15838449 327 sfd--------------------------------hpDQLg---------------------sYSNHCGVAMHYCLAAPG 353 Xylella fastidios...
15900547 1060 AEEGLISIVNTNKEGENQRDLkvisrehfirgilnsksndakgikssklkvwgdlkwdgliynprgreenapeskdnqdp 1139 Streptococcus pne... 15792688 298 VSGTAALVKQNFPFLDGKQIAd---------------------------------------------------------- 319 Campylobacter jejuni 19704758 276 NAKYWSISADDSAIPTAG-------------------------------------------------------------- 293 Fusobacterium nuc... 19705252 246 NAKWWAISADAEVVDSKG-------------------------------------------------------------- 263 Fusobacterium nuc... 15793479 394 -YEASVRFTRTNPIQIAG-------------------------------------------------------------- 410 Neisseria meningi... 15677799 408 -YEASVRFTRTNPIQIAG-------------------------------------------------------------- 424 Neisseria meningi... 1170704 105 SESDELLNEFSNHFGISDPLFygqw------------------------------------------------------- 129 fission yeast 15836872 259 DLIEIDPNVTTSPVDGDKGYLng--------------------------------------------------------- 281 Xylella fastidios... 15837628 259 DVVVIHNSVTNSSSVDDEy------------------------------------------------------------- 277 Xylella fastidios... 15838449 354 NVLVIDSNVTTTPIGNDGy------------------------------------------------------------- 372 Xylella fastidios...
15900547 1140 atkirgqfepiaegqyFYKFKyrltkdypwqvsyipVKIDNtaPKIVSVDFSNPekiklitkdtyhkvkdqyknetlfar 1219 Streptococcus pne... 15792688 320 ---------------iLLSTAn--------------KNYKApkFTVKQVTDGTNq------------------------- 345 Campylobacter jejuni 19704758 294 ----------------RAGIG---------------SSYAA--PRVSRAAALVA-------------------------- 314 Fusobacterium nuc... 19705252 264 ----------------VTHRG---------------SSFAA--PRVAKVAALVA-------------------------- 284 Fusobacterium nuc... 15793479 411 ------------------------------------TSFSA--PIVTGTAALLL-------------------------- 426 Neisseria meningi... 15677799 425 ------------------------------------TSFSA--PIVTGTAALLL-------------------------- 440 Neisseria meningi... 1170704 130 -------------hifNSNNPghdlnl----revwdAGYFG---ENVTVAFVDDgidfkhpdlqaay------------- 176 fission yeast 15836872 282 ---------------yLIQNG---------------TSFAA--PLVSGAAALVW-------------------------- 303 Xylella fastidios... 15837628 278 ---------------yELQ-G---------------TSFAA--PLVSGAAALVW-------------------------- 298 Xylella fastidios... 15838449 373 ---------------eEQR-G---------------TSFSA--PLVSGAAALVW-------------------------- 393 Xylella fastidios...
15900547 1220 dqkehpekfdeianevwyagaalvnedgeveknlevtyagegqgrnrkldKDGNTIYEIKGAGdlrgkiievialdgssn 1299 Streptococcus pne... 15792688 346 --------------------------------------------------PKFLIVYISQDPP----------------- 358 Campylobacter jejuni 19704758 315 ---------------------------------------------------EKFDWMTADQVR----------------- 326 Fusobacterium nuc... 19705252 285 ---------------------------------------------------EKYDWMTADQVR----------------- 296 Fusobacterium nuc... 15793479 427 ---------------------------------------------------QKYPWMSNDNLR----------------- 438 Neisseria meningi... 15677799 441 ---------------------------------------------------QKYPWMSNDNLR----------------- 452 Neisseria meningi... 1170704 177 --------------------------------------tslgswdfndniADPLPKLSDDQHGtrcagevaaawnd---- 214 fission yeast 15836872 304 ---------------------------------------------------EAFPYFSNDLVR----------------- 315 Xylella fastidios... 15837628 299 ---------------------------------------------------EAFPYFSNDLVR----------------- 310 Xylella fastidios... 15838449 394 ---------------------------------------------------EVFPYFNNDLVR----------------- 405 Xylella fastidios...
15900547 1300 ftkihrikfanqadekgmISYYLVDPDQDSSKYQklgeiaeskfKNLGNGKEGslkkdttgvehhhqeneesikekssft 1379 Streptococcus pne... 15792688 359 ------------------GIEDEIKRDLKQLYNGiqvqvngqwiDYSDYIWDN--------------------------- 393 Campylobacter jejuni 19704758 327 ------------------QTLFTTTDDTELDASLag------naNAEKRRRVKt-------------------------- 356 Fusobacterium nuc... 19705252 297 ------------------QTLFTTTDRTNIDE------------NETYIRNIVt-------------------------- 320 Fusobacterium nuc... 15793479 439 ------------------TTLLTTAQDIGAVG------------------------------------------------ 452 Neisseria meningi... 15677799 453 ------------------TTLLTTAQDIGAVG------------------------------------------------ 466 Neisseria meningi... 1170704 215 -----vcgvgiaprakvaGLRILSAPITDAVESEalnygfqtnhIYSCSWGPAddgramdapntatrr------------ 277 fission yeast 15836872 316 ------------------QTLLGTATDLGAPG------------------------------------------------ 329 Xylella fastidios... 15837628 311 ------------------QTLLGTATDLGVPG------------------------------------------------ 324 Xylella fastidios... 15838449 406 ------------------QTLLGTATDLGAPG------------------------------------------------ 419 Xylella fastidios...
15900547 1380 idrnistirdfenkdlkklikkkfrevDDFTSETGKRMEeydykyddkgniiayddgtdleyetekldeikskiygvlSP 1459 Streptococcus pne... 15792688 394 -----------------------------RDSAQSQKLN---------------------------------------TS 405 Campylobacter jejuni 19704758 357 --------------------------sPDYKYGWGMLNQ---------------------------------------ER 371 Fusobacterium nuc... 19705252 321 --------------------------ePDEKYGWGMLNR---------------------------------------ER 335 Fusobacterium nuc... 15793479 453 ---------------------------VDSKFGWGLLDT---------------------------------------GK 466 Neisseria meningi... 15677799 467 ---------------------------VDSKFGWGLLDA---------------------------------------GK 480 Neisseria meningi... 1170704 278 -------------almngvlngrnglgSIFVFASGNGGHyhdncn----------------------------fdgytNS 316 fission yeast 15836872 330 ---------------------------VDEVFGYGALNV---------------------------------------GK 343 Xylella fastidios... 15837628 325 ---------------------------VDEVFGYGALNV---------------------------------------GK 338 Xylella fastidios... 15838449 420 ---------------------------VDEVFGYGALNV---------------------------------------GK 433 Xylella fastidios...
15900547 1460 SKDGHFEILGKISNVsknakvyygnnyksieikatkydfhsktmtfdlyANINDIVDGLafagdmrlfvkdndqkkaeik 1539 Streptococcus pne... 15792688 406 TISSINGVVRVEKEElf------------------------------gqGILDAQKALKgls------------------ 437 Campylobacter jejuni 19704758 372 ALKGPGAFMDVTkygntni------------------------fnaeipAGKTSYFENK--------------------- 406 Fusobacterium nuc... 19705252 336 ALKGPGAFINIRRQYqyspssnn-------------------ifkaditENKVSYFEND--------------------- 375 Fusobacterium nuc... 15793479 467 AMNGPASFPFGDFTAdtk-----------------------------gtSDIAYSFRND--------------------- 496 Neisseria meningi... 15677799 481 AMNGPASFPFGDFTAdtk-----------------------------gtSDIAYSFRND--------------------- 510 Neisseria meningi... 1170704 317 IFSATIGAVDAEHKIpf------------------------------ysEVCAAQLVSAy-------------------- 346 fission yeast 15836872 344 AVLGPAKFDWGDVQVsf--------------------------------dDRRSTWGND--------------------- 370 Xylella fastidios... 15837628 339 AVLGPAKFDWGDVQVsf--------------------------------dDRRSTWGND--------------------- 365 Xylella fastidios... 15838449 434 AVRGPAKFDWGDVKVnf--------------------------------nDSRSTWFND--------------------- 460 Xylella fastidios...
15900547 1540 irmpekIKETKSEypyVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKGYALKVTTYNPGKT 1619 Streptococcus pne... 15792688 438 ---ildANRLSDQdvlKYEQEPNTAYYTINTAGYDAEFSNDISQRKWDESTHLSSAINKPTHLANLNIGLSKEGEGILII 514 Campylobacter jejuni 19704758 407 ------IFGFGGL----VKSGEGTLHLTN-DNSYAGGSVVNRGTLEIHKIHSSKVTVNQAGRLVLHPKALIGYNEAFFNV 475 Fusobacterium nuc... 19705252 376 ------IFGDGGL----EKLGKGTLHLTG-NNSYERGSIVKEGTLEIHKIHANQINVENKGTLVLHSKAIIGYKVNSNSV 444 Fusobacterium nuc... 15793479 497 ------ISGTGGL----IKKGGSQLQLHG-NNTYTGKTVIEGGSLVLYGNNKSDMHVETKGALIYNGAASGGS------- 558 Neisseria meningi... 15677799 511 ------ISGTGGL----IKKGGSQLQLHG-NNTYTGKTIIEGGSLVLYGNNKSDMRVETKGALIYNGAASGGS------- 572 Neisseria meningi... 1170704 347 ------SSGSHLSiltTNPEGTCTRSHGGTSAAAPLASAVYALALSIRPDLSWRDIQHITVYSASPFDSPSQNAEWQKTP 420 fission yeast 15836872 371 ------ITGSGGL----IKRGTGTLVLGGSNNQYTGATQVLGGTLQASSLGASAVSVSNAATLIGSGRFGGAV------- 433 Xylella fastidios... 15837628 366 ------ITGSGGL----IKRGTGTLVLGGSNNQYTGATQVLGGTLQASSLGVSAVSVANAATLIGSGRFGGAL------- 428 Xylella fastidios... 15838449 461 ------ISGGGGL----IKDGTGTLVLAGSANQYSGATQVLGGTLQVSSLGESAVSIAHSATLIGSGRFGGAV------- 523 Xylella fastidios...
15900547 1620 DMLEGNGVYSKEDIAKIQKANPNLRALSETTIYADSRNVEDGRSTQ 1665 Streptococcus pneumoniae TIGR4 15792688 515 SGQNTYEGATLIKQGELKLKGKVKNNAYVEQKAILSGNGIVGQNLN 560 Campylobacter jejuni 19704758 476 ITTVDPTR-ITTGTNLRNKGIVEVNGTTAIIGGDYIAYKGSTTTFN 520 Fusobacterium nucleatum subsp. nucleatum ATCC 25586 19705252 445 IDEKEITASNITAKNLDNKGIVKVTGTTAVIGGDYIAHSGSTTEMD 490 Fusobacterium nucleatum subsp. nucleatum ATCC 25586 15793479 559 --------LNSDGIVYLADTDRSGANETVHIKGDLQLGGEGTLYTR 596 Neisseria meningitidis Z2491 15677799 573 --------LNSDGIVYLADTDQSGANETVHIKGSLQLDGKGTLYTR 610 Neisseria meningitidis MC58 1170704 421 AGFQFSHHFGFGKLDASKFVEVAKDWQVvnpqtwliapeinvnksf 466 fission yeast 15836872 434 --------SNAGTLELGKDG--------LKVQGDYTQLETGRLALH 463 Xylella fastidiosa 9a5c 15837628 429 --------SNAGTLELGKDG--------LKVQGDYTQLETGRLALH 458 Xylella fastidiosa 9a5c 15838449 524 --------SNAGTLEIGTDG--------LKVQGDYTQSETGRLALN 553 Xylella fastidiosa 9a5c
Jiyao W et al.(2023). "The conserved domain database in 2023.",