Conserved Protein Domain Family
WD40

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COG2319: WD40 
WD40 repeat [General function prediction only]
Statistics
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PSSM-Id: 225201
View PSSM: COG2319
Aligned: 288 rows
Threshold Bit Score: 36.2199
Threshold Setting Gi: 400807
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
17227974 1047 SSEALFASQKGLDAVKEGVKAARKLQR-------AIWVDPYTRE--QVQTALYQAVVGVREYN------------RLEGH 1105 Nostoc sp. PCC 7120
19115761    1 ---MVVPTPFYVLRGHSSSVTSVLFDAn------EYLYSGDEAGfvICWCLTSMRPKCAWR-----------------AH 54   fission yeast
19114336    2 ALDEKFQLEVIHLLLQFLNDYGYDESLkal-ekeTGLVSETEDVkrLKQAVLQGDWITAEAAFs----------iMQLRD 70   fission yeast
19112681    1 -MSIVSSVAFVPRGYASEFPKSYDIDEieyerinQLSKLKLEDAraDLQSSMEDSNKANGNGEe-----------TTDGA 68   fission yeast
19112521    1 MRVLVAETGREDNVSVHSREVSVNGSDsgt-gndAYKLETDDEHppATPVRGLSTRSQKRPFRplt------iqqDEDVE 73   fission yeast
17366384   10 LENAVFGNINNFSSFLDKENETFDVMMn-----eAPELSEDNDAqeDELEKLEDAELFMFDTG------------SADGA 72   fission yeast
3183237    25 LGQPSSSAKSVGRAIVGGLESVLEWDLktg-qllSKWKDSDCSAkvTCIANFDEMYAVGYADGsirlwkdgelliTLNGH 103  fission yeast
10383804    1 ----MSTLIPPPSKKQKKEAQLPREVAi------IPKDLPNVSIkfQALDTGDNVGGALRVPga----------iSEKQL 60   baker's yeast
131666      9 PRGFSSEFPEKYVLDDEEVERINQLAQlnlddakATLEEAEGESgvEDDAATGSSNKLKDQLDidd------dlkEYNLE 82   baker's yeast
1709554     1 ---MTNWQQQLPLTDTQKNELDKSVLR-------YLNWNYKQTVrhEHAQDYESVRHAIVTLSgf---------lLQESV 61   baker's yeast
17227974 1106 TAGVNSAVFSPDGSLIASAS---ADNTINLWRSDGS-----------LINTLSK-Ht-------NVVNSVNF--SPDAL- 1160 Nostoc sp. PCC 7120
19115761   55 TKTILGMQIVKGGALCTHGR----DCRLVTWKIDFNc----------MTDNFMS-Ls--------KLAELQN----YGP- 106  fission yeast
19114336   71 ESKRKEAQFLLQKQRCLELAr--SGAICEAIYVLQNf----------ESTDFNKeKe-------RLVSIILE--SNNKSn 129  fission yeast
19112681   69 EGVLQTSEEVDDELKVYNLDt--YDDDEEEAETEGPa---------aMFSNIRGlAyhen-gekDPYITIDPqeQDDLE- 135  fission yeast
19112521   74 NDTGMNTEYNDDNSSLVNTP---RDSTTYAETNSPN------------TEKLAGrDd------dRSLLNLIDrgEIDSK- 131  fission yeast
17366384   73 KDSVPLDIIAGDNTVKEDEEa--SNEIPSIWEDSDDe---------rLMISLQDhSr------lRKLRQYEDedMVNGLq 135  fission yeast
3183237   104 KSAVTTMDFDKMGTRLASGS---MDTDIIVWDIVAEtglfrlrghkdQITKLLFiTppskntaeETVVDTDId-SGDMDv 179  fission yeast
10383804   61 EELLN--QLNGTSDDPVPYT---FSCTIQGKKASDPv---------kTIDITDN-Ly-------sSLIKPGY--NSTED- 115  baker's yeast
131666     83 EYDDEEIADNEGGKDVSMFPglsNDSDVKFHEGEKGe---------dPYISLPNqEd-------SQEEKQELqvYPSDN- 145  baker's yeast
1709554    62 DRQEFISNNDTSNESMVDID---ELLLPKKWNSIVRlq--------kKIIELEQnTet----lvSQIKDLNTqvSELAQf 126  baker's yeast
17227974 1161 ------LIASA-SQ-DK---TVKLWNRV----GQLVTTLQGHGDVVN---NASFSPDGS-----LIASGS-----SDKTV 1212 Nostoc sp. PCC 7120
19115761  107 -------EASSeTE-KS---SAFIS--------IHSNIVVNSLTFCP----FSYSPQSK-----IVVLCNt---lNFEEL 155  fission yeast
19114336  130 -----nELITKnGYgNT---RLDLLNQLs---EYISPEILLPKRRLEh--LLQQAKDYQ-----VSSQVYhnvlkNFSFL 191  fission yeast
19112681  136 ------REEMQiLPtDS---LLLAARTEd--nLSHVEVYVYEPTEEN----LYVHHDFLl---pTFPLCLe---wLDYKV 194  fission yeast
19112521  132 ------RQRHYvPVhCK---RMPKKEITln-qKLYVSQVIGPADAPK---SKTIFGKR-------IMQWEp----sQFKE 187  fission yeast
17366384  136 ------YARRLrTQfER---VYPVPEWAk---kQDVTEEEDEFNALS---EKSVIPKSLk----SLFKSSvs--yINQSS 194  fission yeast
3183237   180 dskssdSFLLSvGK-DS---FMKLWDLSi---qHCVETHVDHQGEIW---AMCVSPDAKr----CLTAGTg------SDV 239  fission yeast
10383804  116 ------QITLLyTP-RA---VFKVKp-----vTRSSSAIAGHGSTIL---CSAFAPHTS-----SRMVTGa----gDNTA 168  baker's yeast
131666    146 ------LVLAArTEdDVsylDIYVYDDGagfhSSDIPVEEGDEADPDvarGLVRDPALYvhhdlMLPAFPlcvewLDYKV 219  baker's yeast
1709554   127 ------KPTTSnGTsAH---NVLKWIPR-----NLPSCLINVESSVT---SVKLHPNLP-----IVFVATd-----HGKL 179  baker's yeast
17227974 1213 KLWSRE-------GKLLNTLSG---HNDAVLGIAWT--PDGQt-----LASV--GADKNIK--LW----N-R-----DGK 1261 Nostoc sp. PCC 7120
19115761  156 DVYDDEs------LYHPQTHKE---DCGKRLQTRIQ--PEES------VGKTgsVMSTSVT--VT----DeK-----YVL 207  fission yeast
19114336  192 SDYKADpse--lpTKEYHVFHD---HSDEVWQISYS--HNGR-------YLAsaSKDKTA---IIf---DvVn----LKR 247  fission yeast
19112681  195 GTSDNAp------GNYVAVGTFd--PEIEIWDLDIIdaVYPA-------AVLgaGASQVNK--------KkK-----KSK 246  fission yeast
19112521  188 SVWASEis----kSGKYLATAG---KDAIIRVWKVIetPERR------ETLLkeGPQSCGR--FFt---PsS-----IFE 244  fission yeast
17366384  195 KLLAPGti----nIKRLKDANFqapSHSGIRCMSIH--PYFP-------LLLtcGFDRTLR--IY----QlD------GK 249  fission yeast
3183237   240 KVWEISfpddnnfTPTTKAFQQlgtFTRQSRDRPITlaYDVSn-----RYVVfqAHDRLLE--VFrlrsSaElekilNRR 312  fission yeast
10383804  169 RIWDCDt------QTPMHTLKG---HYNWVLCVSWS--PDg-------EVIAtgSMDNTIR--LW----DpK-----SGQ 219  baker's yeast
131666    220 GSNSEE-------AANYAAIGT---FDPQIEIWNLDcvDKAFp-----DMILgePLDNSMVs-LK----SkKk----KKK 275  baker's yeast
1709554   180 YAFDLFn-----yTIPLASLQS---HTKAITSMDVLftNYTNsskknyLVIVtaSKDLQIHvfKWv---SeEc----KFQ 244  baker's yeast
17227974 1262 LLK--------TWQGHDDA--ILg-------vAWSPKG--ETIA-TASFDQTIKLWNR--QGN---------LLKTL--- 1307 Nostoc sp. PCC 7120
19115761  208 LAAg-------YESGHVVQ--Y----------ICSLENv------KTVTLDFKAVWKMvyAYK----------------- 245  fission yeast
19114336  248 VFR---------LIGHIDTvaYIr---------WSPDD---RYLlSCSCDKSVILWDAftGEK----------LRDY--- 293  fission yeast
19112681  247 KIN---------DSYHTDAvlAL---------SSNRNAh-NLLV-SGSADTTLKLWDLstCN-----------CVKSf-- 293  fission yeast
19112521  245 PEPv------lECVGHNAEvlSI---------SWSKND---FLL-TSSADRTVRLWHPksTKS----------LAVFr-- 293  fission yeast
17366384  250 VNPl-------VTSLHLRSsaLQt-------aLFHPDG--KRVI-AAGRRKYMYIWDLesAQVq-------kVSRMYg-- 303  fission yeast
3183237   313 RRRkksedvsiTLKDEYEPfaLIrttarassvAWIPGNrtPTLV-TSLQNNSIEVYALdvKSEgsaaplterASRISaie 391  fission yeast
10383804  220 CLGd-------ALRGHSKW--ITslswepihlVKPGSK--PRLA-SSSKDGTIKIWDTv-SRV---------CQYTM--- 274  baker's yeast
131666    276 SKTg-------HITTHHTDavLSm--------AHNKYFr-SVLA-STSADHTVKLWDLnsGN----------AARSLa-- 326  baker's yeast
1709554   245 QIR--------SLLGHEHIvsAVk--------IWQKNN--DVHIaSCSRDQTVKIWDFhnGWS----------LKTF--- 293  baker's yeast
17227974 1308 -SGH-TAGVTAV-TFSP-NGETIGS-ASID-AT--LKLW-S-PQG--LLLGT---------------------------- 1347 Nostoc sp. PCC 7120
19115761  246 --SH-SQPVLSV-EYAG--SKLFST-GADDcIC--LHPT-PsSIAddLGSLPhpi------------------------- 290  fission yeast
19114336  294 --KH-GFSVSCC-CWLP-DGLSFIT-GSPD-CH--ITHW-SlNGEilYKWED---------------------------- 335  fission yeast
19112681  294 -TYH-SDKVSCLdWYSK-APSVLLS-GSYDkTAkiADLR-LeEAPssFQVTS---------------------------- 340  fission yeast
19112521  294 ---H-NEIVTCV-AFHPiDDRYFVS-GSLD-CK--IQLW-SiLRHkiLHWT----------------------------- 334  fission yeast
17366384  304 -QENfQPSMERF-HVDP-TGKYIALeGRSGh----INLL-HaLTGqfATSFK---------------------------- 347  fission yeast
3183237   392 iPGH-RADVRTL-ALSA-NHDVILS-G-AN-GS--LKLW-NkKTTscIRTIEcgyvlaasfinndkcivsayksgelevy 462  fission yeast
10383804  275 -SGH-TNSVSCV-KWGG-QG-LLYS-GSHD-RT--VRVW-DiNSQg-RCINI---------------------------- 315  baker's yeast
131666    327 -SIHsNKNVSSS-EWHMlNGSILLT-GGYD-SR--VALT-DvRISdeSQMSKy--------------------------- 372  baker's yeast
1709554   294 -QPH-SQWVRSI-DVLG---DYIIS-GSHDtTLr-LTHWpSgNG---LSVGT---------------------------- 334  baker's yeast
17227974 1348 ----------LKGHNS---WVNSVSF-S-PD-----GRIFASG---SRD--KTVTL-WRWDEVL---LRNPKGDGNDw-- 1396 Nostoc sp. PCC 7120
19115761  291 --------frKTKHCG---Q-QNIRIrS-DN-------KILATa--GWD--GRGRV-YSCQTLAp-lAVLKYHSDG---- 340  fission yeast
19114336  336 -----------VNIYDmalTSDGTKLyI-VG-------FEQLIn--AED--KHIAI-YSVETREc-iKKISLQSK----- 385  fission yeast
19112681  341 -------------------DVENVAWdQhSE------NNFFIG---TDN--GIVYYcDARNLSK---SVWQLQAHDGp-- 385  fission yeast
19112521  335 ------------ELEY---VVSTICFyP-DGesivvGMFYGLCaiyETKnlQYVSS-WLIHHSPs-rNKKCRVTGl---- 392  fission yeast
17366384  348 -------------IEG---VLSDVLFtSdGS------EMLVLS----YG--AEVWH-FNVEQRS---VVRRWQVQDG--- 392  fission yeast
3183237   463 diassslierIQAHDG---AIWDLAV-G-HD-----GTYFATA---SAD--HTVKL-WSLKSSFd-fVPGTTRKVTTlkl 525  fission yeast
10383804  316 ----------LKSHAH---WVNHLSL-S--T-----DYALRIG---AFD--HTGKK-PSTPEEA---QKKALENYEk--- 362  baker's yeast
131666    373 ----------WSAMAGe--EIETVTFaS-EN-------IILCG---TDS--GNVYS-FDIRNNEnrkPVWTLKAHDAg-- 424  baker's yeast
1709554   335 ------------GHEF---PIEKVKFiHfIE-----DSPEIRFrtpSTDryKNWGMqYCVSASRd-rTIKIWEIPLP--- 390  baker's yeast
17227974 1397 -----------VTSISFSS-D-GETLAAASRDQTVKILSRHGKLLNTFKGHT---------------------------- 1435 Nostoc sp. PCC 7120
19115761  341 -----------INSLAFHPgS--NVIALASKDTRISLWKLY--------------------------------------- 368  fission yeast
19114336  386 -----------VTSICLSKdSkYALTN--LEPHTTFLWDLEENRIVRQYMGhkl-------------------------- 426  fission yeast
19112681  386 -----------ISCLSVNPsVpSFVAT-GSTDRVVKLWNTSDSSPKMVVSRdl--------------------------- 426  fission yeast
19112521  393 ----------qCASIIPNDsKsDNVVLVSTNDNAIRLYNTVTHALVLKLSDAhr-------------------------- 436  fission yeast
17366384  393 -----------VSTTHFCLdPsNKYLAIGSKSGIVNIYDLQTSNADAAPKPVttld------------------------ 437  fission yeast
3183237   526 eqtrqidftddVLAVKISP-D-GRFVAASLLDNTVKVYYLDSLKFFLNLYGHklpvlsmdisydskllvtcsadknvkiw 603  fission yeast
10383804  363 ----------iCKKNGNS----EEMMVTASDDYTMFLWNPLKSTKPIARMTGh--------------------------- 401  baker's yeast
131666    425 -----------ISTLCSNKfIpGMMSTgAMGEKTVKLWKFPLDDATNTKGPSmvlsr----------------------- 470  baker's yeast
1709554   391 -----------TLMAHRAPiP-------NPTDSNFRCVLTLKG------------------------------------- 415  baker's yeast
17227974 1436 ---------------GSIWGVAWSPNRQMIAS---ASKDQTVKLWHQDg-------kILHTlqghq-------davlaVA 1483 Nostoc sp. PCC 7120
19115761      --------------------------------------------------------------------------------      fission yeast
19114336  427 -------------gnFLIGSCFGGKDDTFVLS---GSEDDKIRIWHREsg------kLLATlsghv-------kcvnyVA 477  fission yeast
19112681  427 -------------dvGRVFTCSFTTDESTAFHlaaSGSKGVVRVWDTAtn-----pgVRKAfesr----------vteEV 478  fission yeast
19112521  437 --------------vNGRVLSRLSEDNSYIIS---GSDTNEVVLWHIPn-------kVLINasrkrsvilhlptetfkVC 492  fission yeast
17366384  438 ------------nitFSINSMSFSQDSQVLAIa-sRGKKDTLRLVHVPsfsvfrnwpTSATplgr----------vtcLA 494  fission yeast
3183237   604 gldfgdchksifahqDSIMEVTFQPDTYNFFT---CSKDREVRYWDGKsf------dLILKlrghh-------sevwaLA 667  fission yeast
10383804  402 --------------qKLVNHVAFSPDGRYIVS---ASFDNSIKLWDGRdg------kFISTfrghv-------asvyqVA 451  baker's yeast
131666    471 -----------dfdvGNVLTSSFAPDIEVAGTmviGGVNKVLKLWDVFtn-----rsVRKSfkse----------lenVQ 524  baker's yeast
1709554   416 ---------------HLSWVRDISIRGQYLFS---CADDKSVRCWDLNtgqclhvweKLHTgfv------------ncLD 465  baker's yeast
17227974 1484 WSSDSQVIASAGKDKIV 1500 Nostoc sp. PCC 7120
19115761      -----------------      fission yeast
19114336  478 YNPVDPYQFASAGDDNT 494  fission yeast
19112681  479 TKKERIVQLEDRGAGED 495  fission yeast
19112521  493 SERLTSTIIAPARTAVE 509  fission yeast
17366384  495 FGKGGELCVGNEAGRVG 511  fission yeast
3183237   668 VGPTFVVSGSHDHSIRL 684  fission yeast
10383804  452 WSSDCRLLVSCSKDTTL 468  baker's yeast
131666    525 ARAKEEAQKIGKSSRIA 541  baker's yeast
1709554   466 LDVDFDSNVTPRQMMVT 482  baker's yeast
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