15895789 24 LIFVRNLIILFIFSLITLVAINRNGQYPWG-SDTYGHLYKANILFDSIKKGTL-FLNYDRNWYNGVQPYRYWAPFPYYIL 101 Clostridium aceto... 15895841 193 rVLISLFIIMFLGTSLMVYLKNIEG-YPWG-VDTYGHLFKADFLYKSIRQGNL-YPLFTNYWYNGIQPFRYWAPFSYYLL 269 Clostridium aceto... 15895852 188 kVLASALLFGVLAVLLSLYMAKEKG-YPWG-IDTYGHIFKADFLYRSLKDGNM-YPLFTKLWYNGIQPFRYWAPFPYYIF 264 Clostridium aceto... 20093965 5 DVLCALVAFLVGAVVSSPSLDYGWNWFPSG-ADARGHMTKVWMLEKLWSMGDVpYPKWSEYWYCGYPFLWFYPPLAYFIP 83 Methanopyrus kand... 20094035 2 FGDSRLVLALLVILVGATIANAGNLMYPLLsRDSRAHVLKIWYTYHMLADGRW--DPWCPMWYSGFPYLTYYGSLGYLLG 79 Methanopyrus kand... 20094875 1 -------------------------------------------MSELFERGHW--SYWCPVWYCGFPFLLYYPPLFYLVG 35 Methanopyrus kand... 14521868 1 MKRKLYYLTLATISVIEYIPLYLAPSPPALqINGNGHLFKV----HKLMTSGW--KPWIEDWYAGYPFLRFYPPLSYLTA 74 Pyrococcus abyssi
15895789 102 AVINMFTN-NMITTFDVFVELVF-MVGGMGWLFWGYYTRRQNIAIVLAILWFFIPDNLRVLFSEGNIPFVTVISISPMVF 179 Clostridium aceto... 15895841 270 AACEFLVRgNVSGAYLIFISLIF-FIGALGWLIWGIRERSIFISLVLGILWFFLPENLKVLFYEGNIPRALITALLPYLF 348 Clostridium aceto... 15895852 265 ALLEFLTGgNVSQAYIMFIGLMF-FVGAFGWLLWGNREKRVFICFIFGVLWFLLPENIRIFFFEGNIPRVVIAALIPYLF 343 Clostridium aceto... 20093965 84 ALMTHLAKtDVLTAWKWWTWLAYsLAGPSVYASARLMGASPLGSLIAAVAYQTSYNHIEITFTEGRIPTVAAIVFYALVP 163 Methanopyrus kand... 20094035 80 AAVDAIVK-DPVRTFVVCLIVASaLIGVGVYALVRARGYARKVAVICALLGLTSGGFMKALNWEGVYPTILSLGFGFLAL 158 Methanopyrus kand... 20094875 36 GALNLPLG-DPVQTLRILGLTAVyLLVVGIFFACRQLGFTTFEAALSTLLFLTSPSILWEINRGGIFPMMMSLGFGLLAL 114 Methanopyrus kand... 14521868 75 GVLGKVLG-SDTKGYAATLMLTS-FLGALALHHY--LKSTGREPCISPLIFLLFPWHLTVSYIEGNFPRANAIHLAPLFL 150 Pyrococcus abyssi
15895789 180 FYYYKSM-MGKKIRDYLRLAMLMSILTLTHAMISAIVGMALFIVGLAYAISKKRYYEN-IISLVYALLGMLCSSFWLYPA 257 Clostridium aceto... 15895841 349 YFLWDFVnYGRKW-SILPMTLFMTLITMTHLMVAAMVVTASFVFLFIYSIIFKKVIKP-LQCLTAMGIGIAICGIWLYPA 426 Clostridium aceto... 15895852 344 YFLWGFVeKGKKA-SIIAMAGIMLLIIMCHLMVAAMLGITTFIFLLIYAVLSKKFLRS-IQSIAAMLLCFAIAGIWLYPA 421 Clostridium aceto... 20093965 164 GLLVAVY---RRVWERGRWAGYLALVLSLTILMHHSSGLAAITVCLAYVAL--R-----------------ISRSWTLWA 221 Methanopyrus kand... 20094035 159 SCYERWLr-GEKR-HLAYATLLLVPACYSHPLGGLLSGGLILTRGIAEAVLREKLRTPrFLLQSTAPVAIGIAIAFSHYA 236 Methanopyrus kand... 20094875 115 GLLERTLsRGFTPKSALGVIALITLSLFTHPIGGMTCQGALILRVLLEVVPEGSLRPNqWFRALTDRQNLPLLLPAALPL 194 Methanopyrus kand... 14521868 151 LSLYWLRe--KRERYLIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNG----IKVLGAVIGLTSFWYVPF 224 Pyrococcus abyssi
15895789 258 LKGGIMSIDKGAVSDVMQSLTYPLTVSLDPLLRFKD---IEMYYFGLSFGIVILFGILFATRNEIA-----PFVAALIIL 329 Clostridium aceto... 15895841 427 LKGGLTSMDSEATSEVMKFFSAKFTDALNPFIRLTQegrNGMFYYGLSIFVVAVLGIILSKKKSLP-----GFITSVVIF 501 Clostridium aceto... 15895852 422 LKGGLVSMDTDSTSEVMRALSTPFTTSLDPLIRLTAagrSGFFYYGVSIFVISCLGIFLSNKKSVP-----GFLTVIIVF 496 Clostridium aceto... 20093965 222 VG--------------KEEL--PSILPEVPGHAWVL------FAILLSVLAVS-WWLMPALEYRTY-----SYTTKPKWW 273 Methanopyrus kand... 20094035 237 AAIYYKRFLS------ELWLYPPGSVAGVLKDLTVG----GKWSTGLLVTVTGIVGVAYEIRRRT------GFGLFVLFW 300 Methanopyrus kand... 20094875 195 LLAAPQYLPMLLYRGYISPLVTPAPQTPLDCIVTLLs--CPMWSPLPFFILLSVLGAYYALRRSGPgirlyGALTCLIFC 272 Methanopyrus kand... 14521868 225 LFD-------------KKWVEFWNISENKALFKSFSl--NPTLLKSPFGILLILLLLIFAIFAIK------NLVDRKKVI 283 Pyrococcus abyssi
15895789 330 VGTTKSALPLLVKLPMNQLFWMRRFTAFAIAMIFIGLITWIKL----RKSILIIILISLVVDSSAS-----FYILGYNRP 400 Clostridium aceto... 15895841 502 LGSTTAFLPIVSKLPLNQLFWMIRFAPIAYALFTISLLNWKSL----KRYIKLIVLIIIIADSSLS-----FRFSLYPKG 572 Clostridium aceto... 15895852 497 LGTTTAFVPVLLKLPLNQLLWMMRFTPIAYGLFIMSLINWGKC----KKVFMAIFLSLIILDSSLS-----FNFVLFPSE 567 Clostridium aceto... 20093965 274 ISMSSVHDPWEFFVPD---YWKTRYAKYVGAIQFL--LGWAG---------------LILAARRRP-----RTFLPFAIM 328 Methanopyrus kand... 20094035 301 G-MVSIVVTFAFVLGY---WKYLPLGKNMLAERYTTVLMPMLL----AVTAAPVVRQLLRSVKAAW-----AAPLGVAGL 367 Methanopyrus kand... 20094875 273 ASVFSLLAFWSIYKVAPGGQLITHRLPGVLFPLFGALILGCVIrhrpKVFATLAIPQLLLFAVYVWsytqpVDLDSVREG 352 Methanopyrus kand... 14521868 284 LAGLYLYLSLGFYSPT---TWLYSFPLLSIVPPYR----WFDL----EALIIPLLIGESLKRVQRK-----SMVALVIIP 347 Pyrococcus abyssi
15895789 401 YPGDIAKTIDIACSIAKQRVGVLDN------------STYGSFPTYYISy------------nSVNGVKQQVYGWAWQG- 455 Clostridium aceto... 15895841 573 KNLEAIKVLSKAKAVTKQRISLMDD------------STFASYASYYIC--------------NGKDKSAYSYGWAWQG- 625 Clostridium aceto... 15895852 568 KSNTVESIIESAKKVTNQRIALLDS------------SMFGSYPSFYIP--------------SIGKETAYSYGWAWQG- 620 Clostridium aceto... 20093965 329 TGVALLLSFGLVLQKPMERIGFEP-------------KWFLMFSAVILC--------------TFVAFVVDNFRFLRR-- 379 Methanopyrus kand... 20094035 368 LLSGSVGALTYVPPEPPHVTSSAMK------------LWKWMGDSWPDDs-------------YTARCDADPYTHLFD-- 420 Methanopyrus kand... 20094875 353 HIPSPVVHLWKAMDLLPRCVGAGLTspqsllwtlvaaGGFFTLDTKPTEdakcalhylrhqggPYDRVTFDPFTHVPLYr 432 Methanopyrus kand... 14521868 348 FTVLAFMNVPKINPYPQDLIKICEN----------------IK-EEPGD--------------DWRIFVLTDVGEAIN-- 394 Pyrococcus abyssi
15895789 456 ATTANNIVTLNTALENHYFGLMFDRALEVgadTLVIRKRLITK-KSQYKELDKYAAKVGYVKYTENDDAMIYMYP----V 530 Clostridium aceto... 15895841 626 AATSSNIVLLNTALENGYYKYMFDRSLEMgcdTVVLRKSVIKDnRKSFSDIDYGAKLSGYKLCFENADSYIFHKS----T 701 Clostridium aceto... 15895852 621 ASTSKNIVLLNTALENGYYNYMFDRSIEMgcdTVVIRKASLEKkKSSFKLIDEAAKKLNYFLYNETVEGYVYHRE----T 696 Clostridium aceto... 20093965 380 HTVLIMICSMMVVDAAIGLKYAY-RPVHY---TVSELSALLWM-REHTGPWDR-VATVGYRALWG-MEPYITG------A 446 Methanopyrus kand... 20094035 421 ASVPISPIYSGHPTIMGWFSQGDPMFFSL---AARWEWELGWVyDPNTLKTSLWATNTRYLLTKSSLLSKKLSQEpgfvL 497 Methanopyrus kand... 20094875 433 CDSAFVPIESGHYSLLGWFNQGDPAFYSL---AWYVEWQHSWVfYPNAVLTVFHLANVRYVISGSPKWTASLERLpefhR 509 Methanopyrus kand... 14521868 395 ---SYLPAICKKPTLNGWYHEGSPTKAGE----R--RMIYILTyGGNLTPYLK-AYAVRFLITPKEINGYEMVLRig-kY 463 Pyrococcus abyssi
15895789 531 KGTFGTEVNYEGIAIGSYASNITYLFPEFEVGTKPYFDDYTYgeLKNKKAVYLAGFKYRDRDKAEELFLKLSRSGVKVL- 609 Clostridium aceto... 15895841 702 PKAFGVITKYEGLCIGKSAKEIQLLYPSFKIGSSNNLEDYSLndLMKYKIIYLSGFSYNNRSKAEGIVKKLSKKGVRVI- 780 Clostridium aceto... 15895852 697 PKTFGVVTKYYGISIGRSAEEIPLEYTGFKSGASYSIDDYRLeeLQKYKIIYLSGFNYKNKAKAENMISKLSKMGIKVV- 775 Clostridium aceto... 20093965 447 PSVFGWYR--EGTPIRDVVVQYQRSFKRVEPNKALKIGDV----LGVRFLILSSRKPYAKR-----MITELERVGVRPI- 514 Methanopyrus kand... 20094035 498 RKKAGDYRVFEFLGHGGSACVVPHPIAVVDRRLGLRTENAYY--TTLLNFVATPGNRYVFVDATFCDARKFDRVIVRPLt 575 Methanopyrus kand... 20094875 510 LTDFGRYTVFSTSVSPGPAELVPRPILVIDDILRRPNPYY----TMVLNIIPDGGTRRIFVEGSPEDVARFRQIIVRTDr 585 Methanopyrus kand... 14521868 464 KVYKGDTSFFQPVSVIVMGKYYELPFDFVYIKDTKIISGQ------PNVVVLYIGQPSKEEESMLWKFIKNGGTVIWVP- 536 Pyrococcus abyssi
15895789 610 -IDITGME-D--SG---FLNVTGQPIVIKN-------------------KFDELYFN----GNKLNTA-KFPSDYPSWNA 658 Clostridium aceto... 15895841 781 -VDMNRIPtDniTDrmiFLGVISEPIVFDN-------------------KMPDLFFN----KERYVADvKFKEEYKKWNT 836 Clostridium aceto... 15895852 776 -IDMNRIPsDetTNrmsFLGVTAQPITFDK-------------------KLPDLFYE----NEKYVSG-AFKKEYTKWNT 830 Clostridium aceto... 20093965 515 -RDYRWVKvYefNPtmgYEIDDIKSVFLGN-------------------KYRYMRLC----KLLRYDP-KYAPAYAFTRI 569 Methanopyrus kand... 20094035 576 pGDVDRAVkLarEGrkvLLILPVSDTRVAR-------------------AVERLGVR----VSPASPP-SFVPLRKYLPS 631 Methanopyrus kand... 20094875 586 pDTLDEVLrKmkSGr-vLVIVPANDYATARylaerfglhvrpvivcpwePLPSMKVCnrliDAYRFVGiTVPGATPEERT 664 Methanopyrus kand... 14521868 537 -ETKGEFLgIkaEIr-aISNDELRSSLFNVs------------------RFSPFSYNhrswYAPVFSSnIVRPLISVGNY 596 Pyrococcus abyssi
15895789 659 NFLNGVNNRKDYVVVDHRLIKYVGN--KDNKNLTFIGLNIPYFVFLTKDEGLMKVLEQALDMKSYE-LPKRVVKDVKIQI 735 Clostridium aceto... 15895841 837 VYLTNTQNVKGFSWINDKKIAFLASgiKDNKNVYFLGFNLMFNGMTNEDSKSLDIMNEIIGKELTN-VPKREIVPLKVSY 915 Clostridium aceto... 15895852 831 VYLQNVSDIKGFSWIKDKKLTFMGKgtGDNKNITFVGFNLMFHAMTNEDNGALSIMDNVMGSNKE--TPTRTIVPLNVKY 908 Clostridium aceto... 20093965 570 PDCDLVRYAHPQVVVMDRHPSPEEVrvLKEFGVKEILVLDRYHKFKTKIFGINIVHDRPLRIVKM--LPKRNLKPIRVDL 647 Methanopyrus kand... 20094035 632 AYRVDGRWWKDVRVGHGLVRVCGVDvvYFTMRFHRLIKEVQTEGYRMPRLPTDEERKFVNGVLRGFdSGKPTQVHLEYRG 711 Methanopyrus kand... 20094875 665 WFLFNGRPWVDVKLGKVEVRVCGVDfvDLAGTLHQT----LYYGAGAYPLPPKWERALLNEVLRGFdSGKPRPVKFKAVE 740 Methanopyrus kand... 14521868 597 TLIGEVRIGNGTLYLAGGNLIFHALsyKSSYEISIIRALIGNMDKSTIVNYKLLERSDGRLVAEIN-STERTLIRVSEAY 675 Pyrococcus abyssi
15895789 736 KDNNIKVKGSSKEI-VPIAALDSFVKLKGNYN-SENNLIHLK-SSSVEVKIIYPHMGVGIVISIIIIALTTALSIYIKLK 812 Clostridium aceto... 15895841 916 NKNSIKINSPKKSVnTTIAFLDAYMSDKKIY--MDQNLLNVReKGVTNISVTYPYLKKGIALSLMGLIGLIIL-IVFVFK 992 Clostridium aceto... 15895852 909 SKNSIVIDSRDKDVnTTLAFLDSYKSKDKIY--SDQNLLKVG-KGKTEIQVTYPYLAKGMILSLMGILGFLVL-IMVVYR 984 Clostridium aceto... 20093965 648 GHAWFKVYGRGWVW-VKVPYFPCWIPDRGVRLgGIDNMILLRvPSPTTVKFVWNPHPLWIALSAFSLCVSLYLTFSRQWR 726 Methanopyrus kand... 20094035 712 DPAVMRVCGNGWVY-LKVKYFPAWRSSDGPVYpASCGQMLVRaHGDTVLRYELPQSLSYGSY-AAAVLGTLALGAMLLWM 789 Methanopyrus kand... 20094875 741 -PDDVRVRGKGYIL-VKIGYHPAWHANAPTYR-GSGGLIIVRsTGVTRLRFGFTWWERMLWWGAFAIGLMGSTWLYLRGR 817 Methanopyrus kand... 14521868 676 -----YPYWKGYINgREVRLFRDYRTGLMIFT-FPRNGTLVIeFKDPFLPLRRYSLVGWIILTAYLVIETGKTYKKRYLH 749 Pyrococcus abyssi
15895789 813 NKDMLEE 819 Clostridium acetobutylicum 15895841 993 GKGECIE 999 Clostridium acetobutylicum 15895852 985 GGRHSEE 991 Clostridium acetobutylicum 20093965 727 T------ 727 Methanopyrus kandleri AV19 20094035 ------- Methanopyrus kandleri AV19 20094875 818 DEGR--- 821 Methanopyrus kandleri AV19 14521868 750 SIFEGRR 756 Pyrococcus abyssi
Jiyao W et al.(2023). "The conserved domain database in 2023.",