Conserved Protein Domain Family
COG5647

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COG5647: COG5647 
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
Statistics
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PSSM-Id: 227934
Aligned: 6 rows
Threshold Bit Score: 803.249
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2493914    1 MS------ETLP-----RSDDLEATWNFIEPGINQILgneknqastsKRVYKILSPTMYMEVYTAIYNYCVNKSRSsghF 69  baker's yeast
19074508   1 --------MDIGrr-tlSEEDFSSIWCSIERELGKLA---------------SGGLCSALEIYNKIYVVCTSSTPR---L 53  Encephalitozoon cun...
21759078   1 MTtlntndKDLPiv--kKYDSLNGTWDFLKTGVSQIF----------ERLDEGMTITKYMELYTAIHNYCADASKT---I 65  fission yeast
6014749    1 MQrsaklkIRAPrkfsaNQVDFATHWEVLQRAIGDIFqksts-qlsfEELYRNAYILVLHKYGEKLYNHVQDVIRSr--L 77  fission yeast
19115107   1 MPpea-krIVVKgf--dPRKSRQRQETYYVTMIDRLN----------MALQVVMAGLGLKTGYQELYSGVENLTRA---D 64  fission yeast
1723641    1 MItnkkikISVPeklglSEESFEESWETVKYAIDHIY-------------SDDMADLSFEQVYKTIYTIVLNKKGP---I 64  baker's yeast
2493914   70 STDSRTGQ-STILVGSEIYEKLKNYLKNYILNFK-----QSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQ-KE 142 baker's yeast
19074508  54 ESRLYWKIgDFIYMRAREIRREVFDAKDWIEEYNrgfrkFREMVFAIDELCDFLNECVKGRTMRDLGFLLWERCVLQqTA 133 Encephalitozoon cun...
21759078  66 TVDNFNDQ-TANVLGEALYNNLVLYLEEYLARLRkecisQTNHEEQLAAYAKYWTRFTTSARFINHLFGYLNRYWVKlKN 144 fission yeast
6014749   78 KEETVPAI-YKNYDASLLGNALLDIRKNDSYSTSws-rsLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDKVYSK--- 152 fission yeast
19115107  65 QAS-RCFN-ILQHHMSSGIQLLKDSAESFIQLEG-----TETDTNACTVVVGCWNKWLERVEIVQNIFYYMDKTFLS--- 134 fission yeast
1723641   65 LYN---------RLKDYLIQKLALLRETIVKDNT-----HD--YEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCK--- 125 baker's yeast
2493914  143 RSDgKRHIFDVNT---LCLMTWKEVMFDPSKDVLINELLDQVTLGR--EGQIIQRSNISTAIKSLVALGIdPQDLKKLNL 217 baker's yeast
19074508 134 KYKhTTLGFELVSqgrIEVVKEAIESFRLIVPDAKNPMLYYTQRYEqfALQKIGCKYSEEIKSACEEVER-YSFYVREKI 212 Encephalitozoon cun...
21759078 145 RFT-ETLVYDIYT---LCLVSWHHHVFSHIRDSLLQNLLYMFTKKR--LYEPTDMKYVEVCVDSITSLSFdKTDMTKPNL 218 fission yeast
6014749  153 SAD-KVPVNENGI---YIFREVVLLNSFEIGEKCVETILILVYLER--KGNTINRPLINDCLDMLNSL---PSENKKE-- 221 fission yeast
19115107 135 HHP-DYPTIEELS---LSLFREKLMAVKNIQIPFLNSLLQSFENLH--SSKSTDHAYLQDAMLMLHRT------------ 196 fission yeast
1723641  126 ----PNRCMEVYD---MCLDLFRIEILQKCSSSLISALISDIERIR--NLGSVDSEHTSLWKVLIGMM---ETLHDNRD- 192 baker's yeast
2493914  218 NVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLEN 297 baker's yeast
19074508 213 FYEKSIQDKIFLEESWPKMEMILEEVFILNKRDYLLSEIHRIMSMYRLPVEILAKISGEGECDKHRTDSGGHRTNDFYEL 292 Encephalitozoon cun...
21759078 219 SSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVLHN 298 fission yeast
6014749  222 TLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLE 301 fission yeast
19115107 197 EMYSSVFVPMYLVMLSRFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQRCLITSHLDTLTK 276 fission yeast
1723641  193 SFFLTDFEPVLISATEEYYN--KAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIE 270 baker's yeast
2493914  298 ----EFVVLLDARDIEKITSLYALIRRDFT-LIPrMASVFENYVKKTGeneisSLL-AMHKHNIMKNenanPKKLALMTA 371 baker's yeast
19074508 293 qggsGARKAHNDVFLEKMSVLYRNLSEFKSaYAI-LQEVFTRYVRDESekhihVYSrSIETLYVFHCmlrhVVDVGFLGD 371 Encephalitozoon cun...
21759078 299 ----DFARMLDQNCSEDIIRMYRLMSRTPNgLQP-LRQTFEEFVKRSG------FA-AVAK--IV------PQ---VGGE 355 fission yeast
6014749  302 nqstGFFSMIDSSNFEGLQLVYESFSRVELgVKS-LKKYLAKYVAHHG-----KLI-NETTSQALEG----KMAVGRLSS 370 fission yeast
19115107 277 gi-sQFIEKRDAHSCKLLYALLQFNHETEYlIQP-----WSDCLVDVG---------FKLVN------------------ 323 fission yeast
1723641  271 d---LTHEAMVISNGKLLQEIYDLSSEEKYrVTV--IESIKSYINKNA-------I-NIPFNEGNRK----KGQNAITWS 333 baker's yeast
2493914  372 HSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININefalpagspKSATSKTSEMLAKYSDILLKKAT 451 baker's yeast
19074508 372 RECLKILKKEFSASCMRLKPSLEARLLEFSGCIVGNSGNAFKFLDSEF---------EGADDGGRMSLPFLGDGEVCGDG 442 Encephalitozoon cun...
21759078 356 ADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNvv-----cqRSS-SRSPELLAKYADSILRKSN 429 fission yeast
6014749  371 NATMATLWVQKVLALWDRLNTIISTTMDADRSILNSLSDAFVTFVDG----------YTR---APEYISLFIDDNLKKDA 437 fission yeast
19115107 324 DESKDDTLVQELLSFHKFLQVVVDESFLHDETLSYAMRKAFETFINGAk--------GSQREAPARLIAKYIDYLLRVGE 395 fission yeast
1723641  334 SEIVELYRSQHSFLESIDFGSVRLNNLTGDVSN-AILGDVFSMYFSK----------EGA--LPSEYLSTYVDHCMKRTK 400 baker's yeast
2493914  452 ---KPEVASDMSD--EDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDI 526 baker's yeast
19074508 443 pglGQSFCGKNDFlrQVFGTLYKMVENKHVFYEMYLSGLGKRLLEGNP-NLQEERKLISLMKRKSNQDFMKKAETMIADI 521 Encephalitozoon cun...
21759078 430 ---KNVDIDDVEDclSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDI 506 fission yeast
6014749  438 ---RKAIEGSIEAtlQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKLEGMFNDM 514 fission yeast
19115107 396 ---QASGGKPLKEvfSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDV 472 fission yeast
1723641  401 e--KDAEIVKIKQdlLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRS-LVEIEKWMVQMIKKVLGTFFTSKLEIMLRDI 477 baker's yeast
2493914  527 RLSkileDDFAVALKNEPdYSKAKYPDLQPFVLAENMWP---FSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLW 603 baker's yeast
19074508 522 SIS-------------LS---YNKDVDRFVWILTQAYWP---MQAESQSTRIP---AP-LEMIKKVYDSKFNKKRLHWVW 578 Encephalitozoon cun...
21759078 507 SLS----QEITEAFWQLP-QSRAGNIDFSALVLGTSFWP---LSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLF 578 fission yeast
6014749  515 NLSq---ELLQEYKHNSAlQSAKPALDLNVSILASTFWPi-dLSPHKIKCNFPKVLLAQIDQFTDFYLSKHTGRKLLWYP 590 fission yeast
19115107 473 NIS----KEFTSSFRHSK-AAHNLHRDLYVNVLSQAYWP----SYPESHIRLPDDMQQDLDCFEKFYLSKQVGKKISWYA 543 fission yeast
1723641  478 SLS----SEMYQAFQHST-INSIEYLSFAPQVLTRTSWPfqsTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAH 552 baker's yeast
2493914  604 PLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPglDALV 683 baker's yeast
19074508 579 HLGSVCVEIRGVEIQ-------MNVLQYSVVDLFNKHEEIDFEKVLGLVKMGTKTTDDVLRSLVESNLVVRAGD------ 645 Encephalitozoon cun...
21759078 579 HLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIFLKAKVLLLGDN--DKLG 656 fission yeast
6014749  591 SMGSADVRVNFKDRKYDLNVSTIASVILLLFQDLKENQCLIFEEILEKTNIEVGDLKRNLQSLACAKYKILLKDpkGREV 670 fission yeast
19115107 544 SLGHCIVKARFPLGNKELSISLFQACVLLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVpkSKKP 623 fission yeast
1723641  553 HLSVIEIGCQFNSG--YYEIS-FSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKK---SSS 626 baker's yeast
2493914  684 KPETQFKLSRPYKALKTNINFASGVKNDILQslsgGGHDNHgnklgnKRLTEDeriekelnteRQIFLEACIVRIMKAKR 763 baker's yeast
19074508 646 -----WYRMGDVSKVGEDIRAFYCSESICMA---------H---------EID----------RSAYYQSLVSRILKRRK 692 Encephalitozoon cun...
21759078 657 DPNSTYKINENFRMKKIRVQLNLPIRSEQKQ----ESLETH------KTIEED----------RKLLLQSAIVRIMKARR 716 fission yeast
6014749  671 NAGDKFYFNENFVSNLARIKISTVAQTRVED----DSERKRt----lEKVDES----------RKHQADACIVRVMKDRK 732 fission yeast
19115107 624 SPDTMFYVNEKFTDKLYRVKINQIYLKEERQ----ENSDVQ------EQVVRD----------RQFELQASIVRVMKQKE 683 fission yeast
1723641  627 SGNMKFSVNYFFSSPNRKVKVPVIACPLPSQk--sDNLATAss---vDTYDNE----------IVMELSAIIVRIMKTEG 691 baker's yeast
2493914  764 NLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQR-GDDgESYAYLA 815 baker's yeast
19074508 693 RMCLGDILKEILAEHTERFEYDEAMFSEGVRTLGDKGIIEDvEG---IYVYLP 742 Encephalitozoon cuniculi
21759078 717 TLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERqGRD-E-YIYLA 767 fission yeast
6014749  733 VCEHNQLMAEVTRQLNPRFHPSPMMIKRRIEALIEREYLQRqADNgRIYEYLA 785 fission yeast
19115107 684 KMKHDDLVQYVINNVKDRGIPLVSDVKTAIEKLLEKEYLEReDND--IYTYVT 734 fission yeast
1723641  692 KLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRnADDpSYYHYLS 744 baker's yeast
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