Conserved Protein Domain Family
PRK07219

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PRK07219: PRK07219 
DNA topoisomerase I; Validated
Statistics
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PSSM-Id: 235971
Aligned: 30 rows
Threshold Bit Score: 1038.04
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
257389049   1 MELIITEKENAARRIAEILSDGAATAERENGVNVYRWGTKR----CMGLSGHVVGVDFPPE--YSDWRDVEPAELVAADV 74 
150402130   2 TGLIICEKPNVAKKIAEAL--GKPKKKSHNSVPYYEVERSGenviVASAVGHLYTLQEKTKtkFGDYPVYDIDWVPASTL 79 
134045820   2 TGLIICEKPNVAKKIAEAL--GKPKKKSHNSVPYYELERQGetivVASAVGHLYTLQEKTKtkFGDYPVYDIQWVPASTL 79 
159906081   2 TGLIICEKPNVAKKIAEAL--GKPKKKSHNSVPYYEVERSGenviVASAVGHLYTLQEKNKakFGDYPVYDIDWVPASTL 79 
73669624    2 TIVAFAEKNKAASQIASILGEGEVERITVEGLPVYEFKWKGeewlVMGLSGHIMNYDFPEQ--YNKWKEVNPGVLLEIDP 79 
91772728    2 TTVVFTEKNKAAAQISTILSGGSAKRSIVDGVSVYEFQRDGslwkIMGLAGHIMGYDYPEE--FHNWRDVDPAALLDTDP 79 
45358519    2 TGLIICEKPNVAKKIAEAL--GKPKKKSHNSVPYYELERNGesivVASAVGHLYTLQEKTKtkFGDYPVYDINWVPASTL 79 
21226285    2 TVVAFAEKNKAAAQIASILGEGEVDKISVEGLPAYEFKWKGeewlVMGLSGHIMNYDFPEK--YNKWSEVDPGTLLGVDP 79 
20090640    2 TVVAFAEKNKAAAQIASILGDGEVDKISVEGLPAYEFKWKGeewlVMGLSGHIMNYDFPEQ--YNKWSEVNPGTLLGVDP 79 
297619292   2 TGLIICEKPNVAKKIADAL--GKPKKKSQSKVPYYEVDTKGktyyVASAVGHLYTLIEKNKtkFGDYPTYDIDWAPASTV 79 
257389049  75 VKSATQENIVATLRKLaRRADEATIATDYDREGELIGKEAYELIRee-tDVPVDRVRFSSITDREVREAFANPDEIDFDL 153
150402130  80 DEKKYIQKYIDALKKVsKEANKFYVATDWDIEGELIG---YHALNfscgQKNAHRLRFSSLTKKEIVKAYETPNEIDFGL 156
134045820  80 DEKKYIQKYIDALKKVsKGANKFYVATDWDIEGELIG---YHALNftcgQKNAHRLRFSSLTKKEIAKAYENPNEIDFGL 156
159906081  80 DEKKYIQKYIDALKKVsKEANKFYVATDWDIEGELIG---YHALNfscgQKNAHRLRFSSLTKKEIVKAYETPNEIDFGL 156
73669624   80 QKLVTRTDYAAAVKNLaKRANKIVLACDYDREGENIGFEAKTLAEkv-tNVPIERARFSSLSPKEVKKAFESLINPDYNM 158
91772728   80 VKQINKASFGSAILKIsKGADLLVLACDFDREGENIGFEAKSIAEkv-sDATVKRARFSSLSKSEIEKAFNDLVEPDENM 158
45358519   80 DEKKYIQKYIDALKKVsKDANKFYVATDWDIEGELIG---YHALNfscgQKNAHRLRFSSLTKKEILKAYENPNEIDFGL 156
21226285   80 EKFVTRKEYEAAIKNLaKRADKIILACDYDREGENIGFEAKTLAEev-tDVPVARARFSALSPKEVRKAFENPVDPDHNL 158
20090640   80 EKFVTRAEYATAIKKLaKRADKIILACDYDREGENIGFEAKTLAEev-tDVPVARARFSALSPKEVRKAFESPVDPDHNL 158
297619292  80 EGKEYVQKYINVLKKLsKDANEYYVATDWDIEGELIG---YHALHhacgQDIAKRMRFSSLTKKEILKSFENTDSIDFGL 156
257389049 154 AAAGEARQVIDLVWGAALTRFLSLSARQLGD--DFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFGDLQGdda---- 227
150402130 157 VDAGDSRHKIDWYFGINVSRALMQAVSSVKRw-KTLSTGRVQGPALAFLVDKEMEIKNFVPTPYWVLEALLDNelia--- 232
134045820 157 VDAGDSRHKIDWYFGINVSRALMQAVSSVKRw-KTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNelia--- 232
159906081 157 VDAGDSRHKIDWYFGINVSRALMQAVSSVKRw-KTLSTGRVQGPALAFLVDKEMEIKNFVPTPYWVLEALLDNelia--- 232
73669624  159 AMAAEARQILDLKMGAAFTRFVTLSVRERARtkDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKITAIFSAesgkegg 238
91772728  159 AMSAEARQILDLKMGASFTRFVTLSVRERARtkGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVF--------- 229
45358519  157 VDAGDSRHKIDWYFGINVSRALMQAVSSVKRw-KTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNdlia--- 232
21226285  159 AMAAEARQILDLKMGAAFTRFVTLSVREKARtkDVLSIGPCQTPTCGFVYEREKAIRAFEAKDFWKITAVF--------- 229
20090640  159 AMAAETRQILDLKMGAAFTRFVTLSVREKARtkDILSIGPCQTPTCGFVYEREKAIRAFKAKDFWKITAIF--------- 229
297619292 157 VDAGDSRHKIDWFFGINISRALMQAISSAKRw-KTMSTGRVQGPALAFLVEKELEIQKFVPVPYWVINANLKN------- 228
257389049 228 -------afEAQYfydd--dgseAERVWDEATAESVYEDLAAlDAATVTSVRERTRTDAPPEPFNTTAFISAAGSL-GYS 297
150402130 233 --------------------iheLEKFWDEEQANEAFEKVKGqKEATVSDVKKTMKSIPPNPPFDLGALQREAHNMfRFS 292
134045820 233 --------------------iheLEKFWDEEEANNAFEKVKDqKQATVSDVKKTMKSIPPNPPFDLGALQREAHNMfRFS 292
159906081 233 --------------------iheLEKFWDEDEANKAFEKVKDqKQATVSDVKKTMKSIPPNVPFDLGTLQREAHNMfRFS 292
73669624  239 kegrkegrkEGKKergdfegthrAGNIHDKEKAAEIFKRLKGtKEGLVAKKTVKETKTSPPNPLNTTEFLKRASKFlGIS 318
91772728  230 -----------TGkgadiigvhrGGHIYDKEKAAAIFKKLKGcKTAVISKKTVKEMNTNPPFPLNTNEFLKRASKYlGVS 298
45358519  233 --------------------vheLEKFWDEEQANKAYEKVKGqKQATVSDVKKSMKTIPPNPPFDLGALQREAHNMfRFS 292
21226285  230 -----------AAkggefegthrAGNIHDKEKAAEIFKRLKGaKEGLVVKKTVKEAKTSPPNPLNTTEFLKRASKFlGIS 298
20090640  230 -----------GAkggdfegthrAGNIHDKEKAAEIFKRLKGaKEGFVVKKTVKEAKTSPPNPLNTTEFLKRASKFlGIS 298
297619292 229 ---------ENENnevpliatheIDKFWDEEEANKAYGNVEGqKEAIVEEIKKTKKKIKPYPPFDLGALQREAHNAfRYS 299
257389049 298 AQRAMSLAEELYTAGYMTYPRTDNTVYPEDLE-PDELLDEFVgSSTFGEDAESLLEQDEIVPTEGDEETTDHPPIHPTGE 376
150402130 293 PKKTQEIAQKLYEKGYCSYPRTSSQKLPDDKAyMDEILKNLSkNKNYKPYIERIL-SENRKPISGKKDDPAHPAVHAVDV 371
134045820 293 PKRTQEIAQKLYEKGYCSYPRTSSQKLPDDKAyMDEILKNLSkNKDYKPYIEKIL-SENRKPISGKKDDPAHPAVHAVDV 371
159906081 293 PKKTQEIAQKLYEKGYCSYPRTSSQKLPDDKAyMEEILKNLSkNKNYRPYIETIL-NENRKPISGKKDDPAHPAVHAVDV 371
73669624  319 PELALEVAEQLYLAGFTSYPRTETNKYAEDFD-FKSLVFDFArQKEYKPFAESILIAP-IVPKNGEKDAHDHPPIHPIRA 396
91772728  299 PDQALEIAEQLYLSGFTSYPRTETNMYADDMD-FASILKGFT-KGDYQDFALLLLSQKAIVPRNGKKDGHDHPPIHPIKA 376
45358519  293 PKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAyMDEVLKNLSkNKNYKPYIETIL-NENRKPISGKNDDPAHPAVHAVDV 371
21226285  299 PEVALETAEQLYLAGFTSYPRTETNKYADDFD-FKSLVFDFArQKEYKPFAESILSAP-IVPKNGEKDAHDHPPIHPIRA 376
20090640  299 PEVALEVAEQLYLAGFTSYPRTETNKYADDFD-FKTLLFDFArQKEYKPFAESILSAP-IVPKNGDKDAHDHPPIHPIRV 376
297619292 300 PKRTQEIAQKLYEKGYCSYPRTSSQKLPKDMEyMNEVLGKLLkSKEYGKYASEIL-EKNLKPIEGKKDDPAHPAIHPVDV 378
257389049 377 LPprGELDD-----DEWEIYELVVRRFFATVAEPAKWAHLRVVAEAAGHSLKANGKRLLEPGYHAVYPYSSASENVVPAV 451
150402130 372 PK--EHLPD-----DELKLYELIARRTIALYWDNTEREYSKINLDINGEPFKLSGSRTVKEGWHEIYYYTKFDEIELPDL 444
134045820 372 PK--EKLPD-----DELKLYELIARRTIALYWDNAKREYSKINLDINGEIFKLSGSRTVEEGWHEIYYYTKFDEVELPEL 444
159906081 372 PK--EHLPD-----DELKLYELIARRTIALYWDNAEREYSKINLDINGEIFKLSGSRTVKEGWHEIYYYTKFDEIELPEL 444
73669624  397 ASr-GEVSSavnipQAPEVYNLIARHFLANLMPAAVFEKTHLHLLVNEEPFDSSGTVLKDSGWLEAYPFENKKDKLLPFV 475
91772728  377 GSr-MEVERaikmpRAWDVYDLIVRHFIANLLPPAVFEKTRFEITMEDELFDSTGSIQKNAGWLAVYPFEKPQDKILPAL 455
45358519  372 PK--EKLPD-----DELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDEVELPEL 444
21226285  377 AAr-GEVSSavnipQAAEVYDLIARHFLANLMPAAVFEKTHLHLQVKEEPFDSSGTVLKEPGWLEVYPFENKKDKLLPFV 455
20090640  377 AAk-GEISAavtipHAAEVYDLIARHFLANLMPAAVFEKTHLHLQVREEPFDSSGTVLKDAGWLEVYPFENKKDKLLPFV 455
297619292 379 PK--EALPD-----DEQKLYNLIARRALAAYWDDAEREYSKITVDINGEKFKLSGSRTTHEGWHEIYYFTKFDENELPEL 451
257389049 452 SEGDALTMSDVSLDAKQTQPPRRYGQSRLIKKMEDFGLGTKSTRHNTIEKLYDRGY--IEGDPPRPTTLAEAVVEAAEEF 529
150402130 445 KEKDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYv-IEDGSLTVTDLGIGVTETLRKY 523
134045820 445 KKKDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYv-IEDGSLTVTDLGIGVTETLRKY 523
159906081 445 KETDIVKVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYv-IEDGSLTVTDLGIGVTETLRKY 523
73669624  476 EEGQKVGVKKLSNTKSKTSPPKKLTEAELLTLMDKNGIGTKATAPTHIETNKKRGYleTKGKTISILDTGFTLMDGLSLT 555
91772728  456 DLGEVLDVKKITNIKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYfeVKGKTIAILDTGFTLMDALNSS 535
45358519  445 KKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYv-IEDGSLTVTDLGIGVTETLRKY 523
21226285  456 EEKERVDVKKLSNTKSKTSPPKKLTEAELLTLMDRHGIGTKATAPTHIETNKKRGYfeNKGKTISILDTGFTLMEGLSLS 535
20090640  456 EEKEKVDVKKLSNTKSKTSPPKKLTEAELLTLMDKHGIGTKATAPTHIETNKKRGYfeTKGKTVSILDTGFTLMDGLSLT 535
297619292 452 KKGKVLPIESTEKLAKETKPPKRYTMASIIKELENRHLGTKATRADILEKLTKRGYv-IEDGSLSVTELGIGVIETLKKY 530
257389049 530 ADRIVSEEMTAQMEADMSAIASGEATLDEVTAESREMLDRVFEELADSREEVGDYLQESLKAD----KT---LGPCPECG 602
150402130 524 CPEIVEETLTRDLEDKLELIQDKKIKKEDVITETQNKLTKILGEFRLKEKEIGNELVDKLDSTnrslQI---IGKC-KCG 599
134045820 524 CPEIVEETLTRDLEDKLELIQDKKIKKEDVIKETETKLTKILGEFRLKEKEIGNELVDKLDSTnrslQI---IGKC-KCG 599
159906081 524 CPEIVEETLTRDLEDKLELIQDKKIKKEDVIKETENKLTKILGEFRLKEKEIGNELVDKLDSTnrslQI---IGKC-KCG 599
73669624  556 VPILVKPEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQLEANKKELTSSIAGTIKDEaaleDKknyIGTCKACG 635
91772728  536 VPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRDLMVTRIAGTITDEaveaDKkshIGKCNECE 615
45358519  524 CPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTnrslQI---IGKC-KCG 599
21226285  536 VPILVKPDIRSKIEALIQEVEDGKKEFEAALADGTVLIKEMYAQLEANKKELTSNIAGTIKDEaaleDKknyIGTCKACG 615
20090640  536 VPILVRPDIRAKIEALIQEVEDGKKEFEAALAEGTALIKEMYAQLEANKKELTSNIAGTIKDEaaleDKknyIGTCKACG 615
297619292 531 CPEIVEETLTRDLEDKLEKIQDHKIKKEQVIDETKVKLSQILDEFRKKEKEIGKELVEKIDSTnrslQL---IGKC-KCG 606
257389049 603 EDLLVRRSRQGsYFVGCDGfPECRFTLPLPSTGEPQVL-DDSCEDHGLNHVKMLAGRDTFVHG---C--PRCEAEKADet 676
150402130 600 GDLIIIRTKGKkRFVGCSNyPDCDVTFPLPQKGRIKVL-NEVCETCHNPIIGLDRVKI--------CvnPDCTTRISEed 670
134045820 600 GDMIIIRTKGKkRFVGCSNyPDCDVTFPLPQKGRIKVL-NEVCEKCQNPVIGLDRLKI--------CvnPDCTTRISEed 670
159906081 600 GDLIIIRTKGKkRFVGCSNyPDCDITFPLPQKGRIKVL-NEVCETCHNPVIGLDRVKI--------CvnQDCNTRISEed 670
73669624  636 HVLRIVQTDSG-RFVGCTGyPDCRNSYPLPKAGALTVLrSKECKKGGVAVLKV-GNKYNWAVGigpC--FTCDLEKECyp 711
91772728  616 RVLRIVSTDKG-RFVGCTGyPQCKNTFPLPKTGALAVQrSRTCKKGGAAVLKV-GSKYFWAVGigpC--FSCDMEKECyp 691
45358519  600 GDMIIIRTKGKkRFVGCSNyPDCEVTFPLPQKGRIKVL-NEVCEKCQNPVIGLDRIKI--------CvnPDCSTRISEed 670
21226285  616 HVLRIIQTDSG-RFVGCTGyPDCRNSFSLPKTGALTVLrSKECKKEGAAVLKV-GNKYNWAVGigpC--FKCEFEKECyp 691
20090640  616 HVLRIVQTDTG-RFVGCTGyPDCRNSFPLPKTGALTVLrSKECKKGGAAVLKV-GNKYNWAVGigpC--FKCELEKECyp 691
297619292 607 GDLIIIKYKGKsRFVGCSNyPDCDITYPLPQKGAIKVP-NKVCEVCGLPIINYMGKDL--------CvnIECSSRISEed 677
257389049 677 ---------ddEVIGACPECGegaapeeqrgeggdseaqsasdhssgqspreetaeahgGKLAIKRLRSGSrLVGCTRYP 747
150402130 671 kke---iekaeKEEKICPKCG--------------------------------------GKLLIKKGPYGV-FRGCENYP 708
134045820 671 kke---ieraeKEEKICPKCG--------------------------------------GKLLIKKGPYGV-FRGCENYP 708
159906081 671 kke---iekaeKEEKICPKCG--------------------------------------GKLLIKKGPYGV-FRGCENYP 708
73669624  712 ----------pETVGPCPECD--------------------------------------GSMFLINFKDTR-FLGCTK-- 740
91772728  692 ----------pEIVGECPACD--------------------------------------GQTFLITTKDSR-FLGCTK-- 720
45358519  671 kke---iekaeKEEKICPKCG--------------------------------------NKLLIKKGPYGV-FRGCENYP 708
21226285  692 ----------pETVGPCPECD--------------------------------------GSMFLISFKDNR-FLGCTK-- 720
20090640  692 ----------pETVGPCPECD--------------------------------------GSMFLISFKDSR-FLGCTK-- 720
297619292 678 kkilekienekEEEKICPKCG--------------------------------------GTLTIKRGAFGV-FRGCSNYP 718
257389049 748 DCEYSLPLPRNGDIVVGEDRCAEHDLPEISIVDDEDDddpweLGC---PICNYAEYQARNA 805
150402130 709 KCKYTEKLNGESNEKEIVGKCPKCGSDLFKRRGRFGEf----IGCsnyPKCRHTEKIEKKK 765
134045820 709 KCKYTEKLNGESNEKEIVGKCPKCGSDLYKRRGRFGEf----IGCsnyPKCRHTEKIEKKK 765
159906081 709 KCKYTEKLNGESNEKEIVGKCPKCGSDLFKRRGRFGEf----IGCsnyPKCRHTEKIEKKK 765
73669624  741 RCGYTHSVPKTGKLTILDKTCETCGWKLFRLKDGDRPe----EEFcinRRCTEGRKYWKKP 797
91772728  721 RCGHTQSVPKNGRLTITDKVCEGCGWRLLRVKEQGKDa----KEYcanRKCEVAAQMRSSY 777
45358519  709 KCKYTEKLNGESNEKEIVGKCPKCGSDLYKRKGRFGEf----IGCsnyPKCRHTEKIDKKK 765
21226285  721 RCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEVEGnesleEDIcinRRCTEGIKYWKKV 781
20090640  721 RCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEEKPe----LDFcvnRRCPEGRKYWKQA 777
297619292 719 ECKYTENLKGESNEKEIVGKCPKCGSDLVKRKGRFGEf----IGCsnyPKCRHTEKILKEG 775
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