1BP1


Conserved Protein Domain Family
BPI1

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cd00025: BPI1 
Click on image for an interactive view with Cn3D
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.
Statistics
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PSSM-Id: 237992
Aligned: 15 rows
Threshold Bit Score: 136.35
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
apolar bindingBPI
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:apolar binding pocket
Evidence:
  • Comment:formed mainly by alpha helices and the beta sheet beneath them
  • Comment:binds acyl chains of phosphatidylcholine
  • Comment:may also bind acyl chains of lipopolysaccharide
  • Citation:PMID 9188532
  • Structure:BPI1, binds phosphatidylcholine
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #    #  #   #  #                                                           
1BP1        4 GVVVRISQKGLDYASQQGTAALQKELkRIKIPDYSDSFkikh----------lgkGHYSFYSMDIREFQLPSSQISMVpn 73  human
AAG42844   31 GVVVRISQKGLDYASQQGTAALQKELkRIKIPDYSDSFkikh----------lgkGHYSFYSMDIREFQLPSSQISMVpn 100 human
AAH19847   21 GCKIRVTSKALELVKQEGLRFLEQELeTITIPDLRGKEg---------------hFYYNISEVKVTELQLTSSELDFQpq 85  human
115110     30 GIVARITQKGLDYACQQGVLTLQKELeKITIPNFSGNFkiky----------lgkGQYSFFSMVIQGFNLPNSQIRPLpd 99  Bos taurus
AAH04795   29 GVVARITDKGLAYAAKEGLVALQRELyKITLPDFSGDFkika----------vgrGQYEFHSLEIQNCELRGSSLKLLpg 98  house mouse
AAL60017   66 HISIIVSETGLEFAKDYLIKKVITTTlPLQLPDIENKVkipl----------igkVRMGLSNIQIDAVHVQSSKMETRk- 134 thale cress
Q10011     22 TLKVRLNVPFFKFFSKNGHHVVDEEIpKITIPEIRLPFsss-----------ighGVVRTDDLKIEKFSSPKIDFKLSk- 89  Caenorhabditis ele...
NP_563724  28 FTSVLVSQNGLDFVKNLLVNKAIASIiPLQIPRIEKSMkipf----------lggIDVVVSNLTIYELDVASSYVKLGe- 96  thale cress
XP_066207  21 GALLRLGMDIMNREVQSAMDESHILE-KMAAEAGKKQPgm--------------kPIKGITNLKVKDVQLPVITLNFV-- 83  human
CAC18886   25 GTLARIDKDELGKAIQNSLVGEPILQ-NVLGSVTAVNRgllgsggllggggllghGGVFGVVEELSGLKIEELTLPKVll 103 human
Feature 1       #                                                # #          #               
1BP1       74 VGLKFSISnANIKISGKWKaqkr------flkmSGNFDLSIEg--MSISADLKLGSnptsgkPTITCSSCSSHINSVHVh 145 human
AAG42844  101 VGLKFSISnANIKISGKWKaqkr------flkmSGNFDLSIEg--MSISADLKLGSnptsgkPTITCSSCSSHINSVHVh 172 human
AAH19847   86 QELMLQITnASLGLRFRRQllyw------ffydGGYINASAEg--VSIRTGLELSRdpa-grMKVSNVSCQASVSRMHAa 156 human
115110    100 KGLDLSIRdASIKIRGKWKarkn------fiklGGNFDLSVEg--ISILAGLNLGYdpasghSTVTCSSCSSGINTVRIh 171 Bos taurus
AAH04795   99 QGLSLAISdSSIGVRGKWKvrks------flklHGSFDLDVKg--VTISVDLLLGMdps-grPTVSASGCSSRICDLDVh 169 house mouse
AAL60017  135 DGIILSVLgATANLSMDWSytyras--ffeisdHGDASVEVKg--MNVRITATLVNdn--gsLKIASRENDCTVKNIDIh 208 thale cress
Q10011     90 TGINWWTTgGAIKLSGRWHakftev---itirdKGWLNAYATgiqMNISAAAYQLDg----qPQVKIGDCTVQIQKLDVe 162 Caenorhabditis ele...
NP_563724  97 TGVVIVASgTTCNLSMNWHysystwlppieisdQGIASVQVQg--MEIGLSLGLKSde--ggLKLSLSECGCHVEDITIe 172 thale cress
XP_066207  84 PGVGIFQC-VSTGMTVTGKsf-----------mGGNMEIIVA---LNITATNRLLRdeetglPVFKSEGCEVILVNVKTn 148 human
CAC18886  104 KLLPGFGVqLSLHTKVGMHcsg---------plGGLLQLAAE---VNVTSRVALAVssr-gtPILILKRCSTLLGHISLf 170 human
Feature 1                                     #   #   #                                 #     
1BP1      146 iskskvgwliqlFHKKIESALRNKMNSQVCEKVTNSVSSKLQPYFqtlPVMTKIDSVAGINYGLVAPPATTAETLDVQMK 225 human
AAG42844  173 iskskvgwliqlFHKKIESALRNKMNSQVCEKVTNSVSSKLQPYFqtlPVMTKIDSVAGINYGLVAPPATTAETLDVQMK 252 human
AAH19847  157 fggtf-kkvydfLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLdtvPVRSSVDELVGIDYSLMKDPVASTSNLDMDFR 235 human
115110    172 isgsslgwliqlFRKRIESLLQKSMTRKICEVVTSTVSSKLQPYFqtlPVTTKLDKVAGVDYSLVAPPRATANNLDWLLK 251 Bos taurus
AAH04795  170 isgnv-gwllnlFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLqtlPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFK 248 house mouse
AAL60017  209 ingga--swlyqGVVDAFQKMIISTVEKTVSTKIVEKMKKLDSFLqslPKQRKIDDSAAVNLTFTGNPVLGNSSVEVDIN 286 thale cress
Q10011    163 iggsvlswlvnlFETPFSKLVKKVINAQACSAAKGILIEEANRFLhslPSHVDVGANFYVDYFLTQNPHATSEFTEFDLA 242 Caenorhabditis ele...
NP_563724 173 legga--swfyqGMVNAFKDQIGSSVESTIAKKLTEGVSDLDSFLqslPKEIPVDDNADLNVTFTSDPILRNSSITFEID 250 thale cress
XP_066207 149 lpsn---mlpkmVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTn-lSDPMPVGQMGTVKYVLMSAPATTASYIQLDFS 224 human
CAC18886  171 sgl-----lptpLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGa-vLGLVSLGALGSVEFSLATLPLISNQYIELDIN 244 human
Feature 1         
1BP1      226 GEFY 229 human
AAG42844  253 GEFY 256 human
AAH19847  236 GAFF 239 human
115110    252 GEFF 255 Bos taurus
AAH04795  249 GEIF 252 house mouse
AAL60017  287 GLFM 290 thale cress
Q10011    243 ADIV 246 Caenorhabditis elegans
NP_563724 251 GLFT 254 thale cress
XP_066207 225 PVVQ 228 human
CAC18886  245 PIVK 248 human

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