1FAQ,1PTQ,1TBN


Conserved Protein Domain Family
C1
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cd00029: C1 (this model, PSSM-Id:237996 is obsolete and has been replaced by 410341)
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Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second messenger, released by activation of Phospholipase D. Phorbol Esters (PE) can act as analogues of DAG and mimic its downstream effects in, for example, tumor promotion. Protein Kinases C are activated by DAG/PE, this activation is mediated by their N-terminal conserved region (C1). DAG/PE binding may be phospholipid dependent. C1 domains may also mediate DAG/PE signals in chimaerins (a family of Rac GTPase activating proteins), RasGRPs (exchange factors for Ras/Rap1), and Munc13 isoforms (scaffolding proteins involved in exocytosis).
Links
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Statistics
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PSSM-Id: 237996
Aligned: 49 rows
Threshold Bit Score: 43.2496
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding sites [ion binding site]
Evidence:
  • Citation:PMID 8710867
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:1FAQ
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #                  #  #                   #  #    #  #           #
1FAQ         4 HNFARKTFl------kLAFCDICQKFLL----------NGFRCQTCGYKFHEHCSTKVPt----mC 49   human
2494034    150 HQWAVRWTegadqtddSSFCSYCDESCSssfl---ggsPIWCCLWCQRLVHVDCHSNMSnetgdiC 212  thale cress
Q16760     217 HQWLEGNLp------vSAKCTVCDKTCGsvl-----rlQDWRCLWCKAMVHTSCKESLLt----kC 267  human
1708624    184 HHWREGNLp------sGARCEVCRKTCGssd-----vlAGVRCEWCGVQAHSLCSAALAp----eC 234  human
1708625    125 HHWIRGNVp------lCSYCMVCKQQCGcqp-----klCDYRCIWCQKTVHDECMKNSLkn--ekC 177  human
6225217    622 HRFNVGLNm------rATKCAVCLDTVHfg-------rQASKCLECQVMCHPKCSTCLPa----tC 670  human
2494034     80 HSWELDPIar----akNLNCCVCLKSMSpsqaivasesFFHRCTICGAAAHFNCSSSAPk----dC 137  thale cress
729891     592 HYWKPTSAs-------GDLCCLNEECIKs--------gQRMKCSACQLVAHHNCIPFVNekstlaC 642  fruit fly
2494031    173 HHWVHRRRq-------DGKCRHCGKGFQqkftfhskeiVAISCSWCKQAYHSKVSCFMLqqieepC 231  Norway rat
6016443    526 HRFIPFSNl------tANWCCHCGYMLPigs-----kkNSRKCSECALTAHAQCVHLVPd----fC 576  Neurospora crassa

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