1QJT,1EH2,1F8H,1C07,1IQ3,1FI6,2SCP


Conserved Protein Domain Family
EH
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cd00052: EH 
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Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.
Links
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Statistics
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PSSM-Id: 238009
Aligned: 57 rows
Threshold Bit Score: 61.0815
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                # # #      #             
1QJT_A      13 YEKYYRQVEagntgrVLALDAAAFLKKsglpdLILGKIWDLADTDGKGVLSKQEFFVALRLVACAQN 79   house mouse
1EH2        17 YDAIFDSLSpvn-gfLSGDKVKPVLLNsklpvDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALE 82   human
2SCP_A      96 LPLFFRAVDtnednnISRDEYGIFFGMlgldkTMAPASFDAIDTNNDGLLSLEEFVIAGSDFFMNDG 162  Neanthes diversicolor
NP_566657   19 YKEWFEFSDsdgdgrITGNDAIKFFTMsnlprPELKQIWAIADSKRQGYLGFKEFIVAMQLVSLAQT 85   thale cress
586426      18 YNQKFHQLDtedlgvVTGEAVRPLFASsglpgQLLSQVWATVDIDNKGFLNLNEFSAALRMIAQLQN 84   baker's yeast
NP_173582  428 YTKVFVQVDtdrdgkITGNQARNLFLSwrlprDALKQVWDLSDQDNDSMLSLREFCIAVYLMERYRE 494  thale cress
P36115     488 DSGAINTLPed--glILGIIVRDIWKRsnlpnSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLY 552  baker's yeast
P47030     473 DESHLQPLNlpqdglMLNLVVKDIWYRsnlprDLLVQIYNMVDTRKDGTLDRKSFIVGMWLVDQCLY 539  baker's yeast
O14066    1245 YLLSKSEYSkpn-dlICNIVVRELWSRsgaptSVLAKIYDLVDRHHTGVLGRDEFIVGMFLIDQYLK 1310 fission yeast
NP_567299   20 YKEWFNIADsdgdgrVSGNDATKFFAMsklsrQELKQVWAVADSKRQGFLGLSDSSHWHKKDMKLLQ 86   thale cress

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