Conserved Protein Domain Family

cd00054: EGF_CA 
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Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
PSSM-Id: 238011
View PSSM: cd00054
Aligned: 562 rows
Threshold Bit Score: 28.7566
Threshold Setting Gi: 685200
Created: 1-Nov-2000
Updated: 2-Oct-2020
Aligned Rows:
Ca2+ binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1      #  #                     #                            
1AUT_L       5 DGDQClvlplehpcaslCcgHGTCIXGIGSFSCdCRSGWEG---------RFCQ 49   human
1EMN        43 DTDECsvg-------npCg-NGTCKNVIGGFECtCEEGFEPgp------mMTCE 82   human
1345964    670 EIDECas--------spClnGGQCIDRVDSYECvCAAGYTA---------VRCQ 706  Strongylocentrotus purpuratus
1125776    163 DEDECke--------nfCqnGADCENLKGSYECkCLKGFSG---------KYCE 199  Caenorhabditis elegans
1730110    374 NINEClvn------nggC--SHICRDLVIGYECdCPAGFELvd------rRTCG 413  chicken
S43562     620 AINECasn------lhnCdtHAICQDQPVGYSCrCPFGFIDssptalepgRKCV 667  Caenorhabditis elegans
AAA28092  1772 DIDECalg------lhnCsaAAICIDKKIGYECqCQEGYEDgnps--qpgRICA 1817 Caenorhabditis elegans
6678732    554 ETDECrln------qniCg-HGQCVPGPSDYSChCNAGYRShp-----qhRYCV 595  house mouse
466037    2612 DVDECalg------lnnCsgVAHCIDRAVGYTCkCPDGYIDgnpd--epgRVCG 2657 Caenorhabditis elegans
AAA28092  1215 RFDECadpk-----dndCdkHALCIDTDDSYTCqCKEGFFDeisdpkkpgRVCI 1263 Caenorhabditis elegans

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