1AU1,1B5L,1IFA,1ITF,1RH2


Conserved Protein Domain Family
IFab
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cd00095: IFab 
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Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.
Links
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Statistics
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PSSM-Id: 238047
Aligned: 16 rows
Threshold Bit Score: 183.691
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative IFNAR-1 binding site
Evidence:
  • Comment:mutational studies have shown these residues to be critical in receptor recognition and biological activity
  • Comment:Helices A and C
  • Citation:PMID 9931256
  • Citation:PMID 9417943
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       ##  #  ##  #  ##                                                         ## ##
1AU1_A      6 LGFLQRSSNFQCQKLLWQLNgrl-eyCLKDRMNFDIPEEIkqlQQFQKEDAALTIYEMLQNIFAIFRQDSSS-TGWNETI 83  human
1B5L        3 LSRKLMLDARENLKLLDRMNrlsphsCLQDRKDFGLPQEMvegDQLQKDQAFPVLYEMLQQSFNLFYTEHSS-AAWDTTL 81  sheep
1IFA        4 LQLQERTNIRKCQELLEQLNgk---iNLTYRADFKIPMEMt--EKMQKSYTAFAIQEMLQNVFLVFRNNFSS-TGWNETI 77  house mouse
124466     27 LRFQQRRSLALCQKLLRQLPstp-qhCLEARMDFQMPEEMkqaQQFQKEDAILVIYEMLQQIFNILTRDFSS-TGWSETI 104 Bos taurus
164517     27 LRYQQRSSNLACQKLLGQLPgtp-qyCLEDRMNFEVPEEImqpPQFQKEDAVLIIHEMLQQIFGILRRNFSS-TGWNETV 104 pig
547724     26 LPQTHGLLNRRALTLLGQMRrlpassCQKDRNDFAFPQDVfggDQSHKAQALSVVHVTNQKIFHFFCTEASSsAAWNTTL 105 cat
1082967    25 LSAVHCVEKREIFKHLQEIKkipsqlCLKDRIDFKFPWKResiTQIQKTEGTCYCYLMLQQISSVFSKKDSR-AAWNNTL 103 domestic pig
1170557    35 LRPQDATFSHDSLQLLRDMAptlpqlCPQHNASCSFNDTIl--DTSNTRQADKTTHDILQHLFKILSSPSTP-AHWNDSQ 111 chicken
1708492    26 LPHTHSLPNRRVLTLLRQLRrvspssCLQDRNDFAFPQEAlggSQLQKAQAISVLHEVTQHTFQLFSTEGSA-AAWDESL 104 Bos taurus
6016374    26 LPDTHSLRNWRVLTLLGQMRrlsassCDHYTTDFAFPKELfdgQRLQEAQALSVVHVMTQKVFHLFCTNTSS-APWNMTL 104 dog

Feature 1      ##  #  ##  ##  #                                                            
1AU1_A     84 VENLLANVYHQINHLKTVLEEKLekedft---rgklmsSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFI 157 human
1B5L       82 LEQLCTGLQQQLDHLDTCRGQVMgeedse---lgnmdpIVTVKKYFQGIYDYLQEKGYSDCAWEIVRVEMMRALTVS 155 sheep
1IFA       78 VVRLLDELHQQTVFLKTVLEEKQeerltw----emsstALHLKSYYWRVQRYLKLMKYNSYAWMVVRAEIFRNFLII 150 house mouse
124466    105 IEDLLEELYEQMNHLEPIQKEIMqkqnst----mgdttVLHLRKYYFNLVQYLKSKEYNRCAWTVVRVQILRNFSFL 177 Bos taurus
164517    105 IKTILVELDGQMDDLETILEEIMeeenfp----rgdmtILHLKKYYLSILQYLKSKEYRSCAWTVVQVEILRNFSFL 177 pig
547724    106 LEEFCTGLDRQLTRLEACVLQEVeegeapltnedihpeDSILRNYFQRLSLYLQEKKYSPCAWEIVRAEIMRSLYYS 182 cat
1082967   104 LDQLLSSLDLGLRRLEHMKKDNMdcp----------hvGSALRKYFQGIQLYLKEKKYSPCAWEIVRVEIERCFSLT 170 domestic pig
1170557   112 RQSLLNRIHRYTQHLEQCLDSSDtrsrtr----wprnlHLTIKKHFSCLHTFLQDNDYSACAWEHVRLQARAWFLHI 184 chicken
1708492   105 LDKLRAALDQQLTDLQACLRQEEglrgap---llkedaSLAVRKYFHRLTLYLREKRHNPCAWEVVRAEVMRAFSSS 178 Bos taurus
6016374   105 LEELCSGLSEQLDDLDACPLQEAglaet-----plmheDSTLRTYFQRISLYLQDRNHSPCAWEMVRAEIGRSFFSL 176 dog

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