1BO1


Conserved Protein Domain Family
PIPKc
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cd00139: PIPKc (this model, PSSM-Id:238081 is obsolete and has been replaced by 340436)
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Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II phosphatidylinositol phosphate kinases (PIPKII-beta), type I andII PIPK (-alpha, -beta, and -gamma) kinases and related yeast Fab1p and Mss4p kinases. Signaling by phosphorylated species of phosphatidylinositol regulates secretion, vesicular trafficking, membrane translocation, cell adhesion, chemotaxis, DNA synthesis, and cell cycling. The catalytic core domains of PIPKs are structurally similar to PI3K, PI4K, and cAMP-dependent protein kinases (PKA), the dimerization region is a unique feature of the PIPKs.
Links
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Statistics
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PSSM-Id: 238081
Aligned: 16 rows
Threshold Bit Score: 371.24
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP-binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
1BO1_A      39 SEPILSVLMWGVNHTINElsnvpvp-vmlmpdDFKAYSKIKVDNHlfnke-------nlpsRFKFKEYCPMVFRNLRERF 110  human
1931652    437 NYYLMLNLQLGIRYTVGKitpvpr--revrasDFGKNARTKMFFPrdgsnft---pphksvDFSWKDYCPMVFRNLRQMF 511  thale cress
7488008    382 NYELMLNLQLGIRHSVGRqapaasldlkpsafDPKDKIWRRFPREgtkytp-----phqstEFKWKDYCPLVFRSLRKLF 456  thale cress
7487892    328 NYDLMLNLQLGIRYSVGKhasllre-lrhsdfDPKDKQWTRFPPEgskstp-----phlsaEFKWKDYCPIVFRHLRDLF 401  thale cress
1709144    385 NFIIAYNMLTGIRVAVSRcsgimk---pltpaDFRFTKKLAFDYHgnelt------pssqyAFKFKDYCPEVFRELRALF 455  baker's yeast
7492814    267 NYVTAYNMLTGIRVGVSRcqakmd--reltpaDFTARHKFTFDITgnelt------psakyDFKFKDYAPWVFRHLRQLF 338  fission yeast
7494586   1042 GSIIAYALSAVDYNKIPEaadtvsmdsassslKFSQMDDGENLASsqhleve---fedesaSYYVKMLYAEKFRKLRELL 1118 Caenorhabditis e...
7491727    281 SFTLSSPDYLSKMVEIEDsmdeal---tnqglQGSTQFKIENLMLkptgthlkyqfeegsaRLSCKVFFAEQFSALRRAC 357  fission yeast
462047    1948 EGLLNTPPIEGARDRTPQesqthsqanldtlqELEKIMTKKTATHlryqf------eegltVMSCKIFFTEHFDVFRKIC 2021 baker's yeast
7486447   1409 SLSDLSVDMSRSLSSADEqvsqllh-sslylkDLHARISFTDEGPpg------------kvKYSVTCYYAKEFEALRMIC 1475 thale cress

Feature 1                                    #        # #                                      
1BO1_A     111 g-IDDQDYQNSVTRSa-PINSdsqGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHg---NTLLPQFLG 185  human
1931652    512 k-LDAAEYMMSICGDdgLTEIsspGKSGSIFYLSHDDRFVIKTLKKSELQVLLRMLPKYYEHVGDHE----NTLITKFFG 586  thale cress
7488008    457 k-VDPADYMLSICGNdaLRELsspGKSGSFFYLTNDDRYMIKTMKKSETKVLLGMLAAYYNHVRAFE----NSLVIRFFG 531  thale cress
7487892    402 a-IDQADYMLAICGNesLREFaspGKSGSAFYLTQDERYMIKTMKKSEIKVLLKMLPNYYEHVSKYK----NSLVTKFFG 476  thale cress
1709144    456 g-LDPADYLVSLTSKyiLSELnspGKSGSFFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHVRDNP----NTLICQFYG 530  baker's yeast
7492814    339 h-LDAADYLVSLTSKyiLSELdspGKSGSFFYFSRDYRFIIKTIHHSEHKFLREILYDYYEHVKNNP----NTLISQFYG 413  fission yeast
7494586   1119 iaEGEETFIRSLSNSt-FWTPq-gGKSGSFFYRTQDDRFVVKQMSRFEIQSFVKFAPNYFDYLTTSAteskLTTLCKVYG 1196 Caenorhabditis e...
7491727    358 --GCEETFVTSLARCs-LWESs-gGKSGSAFLKTFDKKYILKVLSRLESDSLLNFAPAYFDYISKVFfhelPTALTKIFG 433  fission yeast
462047    2022 --DCQENFIQSLSRCv-KWDSn-gGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMfhdlPTTLAKVFG 2097 baker's yeast
7486447   1476 c-PSETDFIRSLGRCr-KWGAq-gGKSNVFFAKSLDDRFIIKQVTKTELESFIKFGPAYFKYLTESIstksPTSLAKILG 1552 thale cress

Feature 1                             # ###                                                    
1BO1_A     186 MYRLTvd--------gVETYMVVTRNVFShrlTVHRKYDLKGSTVAREASdk-----eKAKDLPTFKDNDFLneg--qkL 250  human
1931652    587 VHRITlk-------wgKKVRFVVMGNMFCtelKIHRRYDLKGSTQGRFTEk------iKIQEKTTLKDLDLAy-----eF 648  thale cress
7488008    532 LHCVKlng-----ptqKKVRFVIMGNLFCskySVHRRFDLKGSSLGRTTDkp----esEIDSNTILKDLDLNf-----iF 597  thale cress
7487892    477 VHCVKpv-------ggQKTRFIVMGNLFCseyRIHKRFDLKGSSHGRTIDkd----egEIDETTTLKDLDLKy-----vF 540  thale cress
1709144    531 LHRVKmpisfqnkikhRKIYFLVMNNLFPphlDIHITYDLKGSTWGRFTNldkerlakDRSYRPVMKDLNWLeeg--qkI 608  baker's yeast
7492814    414 LHRVKlp-------fgRKIHFVVMNNLFPphrDIHQTFDLKGSTLGRELDen----qpCQSPMCTMKDTNWIrrn--mhL 480  fission yeast
7494586   1197 VFRIGyksk----tttLKVDILVMEYLFYn-hNVSQVWDLKGSLRNRLASt------gKSANEMVLLDENFVkdlwnqqL 1265 Caenorhabditis e...
7491727    434 FYRVDirnpt--tgtiCKTDIMIMENVFYd-eCPSRIFDLKGSMRNRHVEs-------TGKVDEVLLDENLVeliyespI 503  fission yeast
462047    2098 FYQIQvkssi-sssksYKMDVIIMENLFYe-kKTTRIFDLKGSMRNRHVEq-------TGKANEVLLDENMVeyiyespI 2168 baker's yeast
7486447   1553 IYQVSskhlk--ggkeFKMDVLVMENLLFk-rNFTRLYDLKGSTRARYNPd-------TSGSNTVLLDQNLVeamptspI 1622 thale cress

Feature 1                                 #   #                                                
1BO1_A     251 HVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtpp------ 324  human
1931652    649 HMDKLLREALFKQIYLDCSFLESLNIIDYSLLLGLHFRapgqlndileppnamsdqesvssvdvgltqehsippkglllv 728  thale cress
7488008    598 RLQKAWYQEFIRQIDKDCEFLEQERIMDYSLLVGIHFReasvagelipsgartpigeseeesgprlsraevdellsd--- 674  thale cress
7487892    541 RLETSWFQAFINQIDLDCEFLEAERIMDYSLLIGLHFResgmrddislgigrrdqedklmrgngplmrlges-------- 612  thale cress
1709144    609 KFGPLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIHDInkakeddlqladtasieeqpqtqgpirt-------------- 674  baker's yeast
7492814    481 QFGPLKRQIFLTQVKADIDMLSSLGIMDYSLLVGIHDLsrgnrdkirnsilsvydpnvsqhrvpsingneshsnvhvirq 560  fission yeast
7494586   1266 YVLPHSKAAMNQAISNDSHFLSSQYIMDYSLLVGVDDD------------------------------------------ 1303 Caenorhabditis e...
7491727    504 FVSEQLKSLLHSCLWNDTLFLSKLNIMDYSLIVGIDYT------------------------------------------ 541  fission yeast
462047    2169 HVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNE------------------------------------------ 2206 baker's yeast
7486447   1623 FVGSKAKRLLERAVWNDTSFLASIHVMDYSLLVGVDEE------------------------------------------ 1660 thale cress

Feature 1                                                                                      
1BO1_A     325 -------------------------------------dspgnllsfprffgpgefdpsvdvyamkshesspkKEVYFMAI 367  human
1931652    729 thepnsvntapgphirgstlrafsvgeqevdlilpgtarlrvqlgvnmpaqahhkliedkeesatielfevyDVVVYMGI 808  thale cress
7488008    675 ---------------------------------psrwasirlgtnmparaertmrkndselqlvgeptgefyEVVMIFGI 721  thale cress
7487892    613 --------------------------------------tpakaeqvsrfeeetweedaidnsnpkgtrkeavEVILYFGV 654  thale cress
1709144    675 ---------------------------------------------gtgtvvrhffrefeggirasdqfnndvDLIYYVGI 709  baker's yeast
7492814    561 vvn-------------------------stgpvsldqscnllptdqfverrnfmfysddggfqatdennepgNFIFYIGI 615  fission yeast
7494586   1304 ------------------------------------------------------------------------NGELILGI 1311 Caenorhabditis e...
7491727    542 ------------------------------------------------------------------------KKELYVGI 549  fission yeast
462047    2207 ------------------------------------------------------------------------GYTLTVGI 2214 baker's yeast
7486447   1661 ------------------------------------------------------------------------RNELVLGI 1668 thale cress

Feature 1      ##                                                   
1BO1_A     368 IDILTPYDTKKKAAHAAKTVKHGAg----AEISTVNPEQYSKRFNEFMSNILT 416  human
1931652    809 IDILQEYNTKKKVEHTCKSLQYDP-----MTISVTEPSTYSKRFVNFLHKVFP 856  thale cress
7488008    722 IDILQDYDISKKLEHAYKSIQYDP-----SSISAVDPRQYSRRFRDFIFKVFT 769  thale cress
7487892    655 IDILQDYDITKKLEHAYKSLHADP-----ASISAVDPKLYSRRFRDFINKIFI 702  thale cress
1709144    710 IDFLTNYSVMKKLETFWRSLRHDT-----KLVSAIPPRDYANRFYEFIEDSVD 757  baker's yeast
7492814    616 IDLLTKYSYVKRVEHLWKGINHSD-----SVISAVPPAEYASRFYKFVESSIK 663  fission yeast
7494586   1312 VDYMRTYTLDKKLESWVKIVAIPGa----HLPTILSPEMYCARFSEAIDSYFP 1360 Caenorhabditis elegans
7491727    550 IDFIRTYTWDKKLESWVKEKGLVGr---gPEPTIVTPKQYKNRFRKAMDCYIL 599  fission yeast
462047    2215 IDFIRTFTWDKKLESWVKEKGLVGgasviKQPTVVTPRQYKKRFREAMERYIL 2267 baker's yeast
7486447   1669 IDFMRQYTWDKHLETWVKTSGLLGgp-knSTPTVISPQQYKKRFRKAMTAYFL 1720 thale cress

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