1XBR


Conserved Protein Domain Family
TBOX

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cd00182: TBOX (this model, PSSM-Id:238106 is obsolete and has been replaced by 410312)
Click on image for an interactive view with Cn3D
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.
Statistics
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PSSM-Id: 238106
View PSSM: cd00182
Aligned: 32 rows
Threshold Bit Score: 269.072
Threshold Setting Gi: 7496428
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerizationDNA binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     #                               
1XBR_A      1 ELKVSLE--ERDLWTRFKElTNEMIVTKNGRRMFPVLKVSMSGLDPNAMYTVLLDFVAADNHRWKYVN--GEWVPGG--K 74   African clawed frog
2501123   203 KAQVYLC--NRPLWLKFHRhQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQG--GKWVPCG--K 276  house mouse
2429447    30 FIRVFLQ--SSNLWRRFHNlGTEMIVTKSGRRMFPTLSVIIAGLDPVKSYVVMVDLECIEMKRFRYSFhqSKWISTG--P 105  Caenorhabditis el...
CAC51029  376 KAVVYLC--NRDLWRKFHQhKTEMIITKQGRRMFPQLVYKLSGLNPTSQYNVFVDMVLCDPNQWKFQC--GKWIPCG--Q 449  common urchin
P55965     86 NLRISLD--DRELWLRFQNlTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVN--GEWVPGG--K 159  fruit fly
2501113    40 GLKVRLD--DVELWKKFHKlTNEMIVTKSGRRMFPVLSASIAGLDPNSMYSVLLDFSAADDHRWKYVN--GEWIPGG--K 113  Hemicentrotus pul...
Q23467    392 NPNVELV--NRNLWSTFLEcGTEMIITKKGRRMFPLVKLKLSGLDKNSNYTIIMEMISVDKLRYKFWN--GNWIVAG--V 465  Caenorhabditis el...
6226711     4 QVYVTLRedQDKLWNLFHYhKNEMIVTKSGRKMFPKLEYVVRGLTPNKLYAMMLHIEPSDDHRYKFSS--GEWVKSG--K 79   Caenorhabditis el...
2501136    88 KVKVSIEgsQETLWKIFHAeVNEMIVTKNGRKLFPKLEYIVEGLDENKLYAIMLQLQPVGESRFKFSG--GKWQETG--K 163  Caenorhabditis el...
BAA34230  318 GTEVKLR--NSDLWKHFDNvVMEMVISKHGRRMFPVLEYDIKGLHPFKLYSVFVDFVLANKYVWKFSE--QKWNPSGlaP 393  Halocynthia roretzi
Feature 1                      ###                                              #             
1XBR_A     75 PEPq--aPSCVYIHPDSPNFGAHWMKDPVSFSKVKLTNKm----NGGGQIMLNSLHKYEPRIHIVRVGgtq--------- 139  African clawed frog
2501123   277 ADTnv-qGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNkgasnNNGQMVVLQSLHKYQPRLHVVEVNedgted--tsqp 353  house mouse
2429447   106 GESe--lPSRMFVHTDSPARGAHWMRAPVSFDKMKLTNNq---lDNNGHIIVNSMHKYRPRVHIIEQDds---------- 170  Caenorhabditis el...
CAC51029  450 AENip-kVSNTYLHPDSPSNGLHWMHQDIVFSKLKLTNHr---gKDNGFVVLNSMHKYQPRIHVLELGes---------- 515  common urchin
P55965    160 AEVp--pSNPIYVHPESPNFGAHWMKEPISFAKVKLTNKt----NGNGQIMLNSLHKYEPRVHLVRVGseq--------- 224  fruit fly
2501113   114 PDGs--pPTTAYIHPDSPNFGAHWMKQAVNFSKVKLSNKl----NGSGQVMLNSLHKYEPRIHIIRVGgrek-------q 180  Hemicentrotus pul...
Q23467    466 GEHh--pLPTCFVHPQSPRSGEWWMTDGVDFKMAKLSNNp---fNNDGHIVLNSMHRYNPRFHIVRADssgqp-----il 535  Caenorhabditis el...
6226711    80 AEKh--rEPKKLWHADGVRSGKEWMTNPVCFDRVKITNCae--sTNASMIFLHSMHKYTPVMSIYESPsespfsvpqpst 155  Caenorhabditis el...
2501136   164 AEKq--vDAKKMWHADGVRKGSDWMWSSICFDRVKISNYse--sNNASMIYLNSMHKYIPVLTIYESPsespfcvpqssn 239  Caenorhabditis el...
BAA34230  394 DEDaydqSHRVCLHPDSPAPGEVWNKRGASFSKMKLSNHl---hTESDKLSLKSLHKYQPRLHVVEVDprdpt-----iq 465  Halocynthia roretzi
Feature 1                                                 
1XBR_A    140 rmITSHSFPETQFIAVTAYQNEEITALKIKHNPFAKAFLDAKER 183  African clawed frog
2501123   354 grVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDT 397  house mouse
2429447   171 qkRHTFSFEETEFIAVTAYQNHRITSLKIESNPFAKGFRECEVQ 214  Caenorhabditis elegans
CAC51029  516 rsLQTHSFPETRFFGVTAYQNTDVTQLKIDYNPFAKGFRDNYDN 559  common urchin
P55965    225 rhVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKER 268  fruit fly
2501113   181 rlVGSYSFTETRFIAVTAYQNEDITQLKIKYNPFAKAFLDIKDK 224  Hemicentrotus pulcherrimus
Q23467    536 asLKTFSFKETEFIAVTAYQNDVVTKCKIDNNPFAKGFRNIDTV 579  Caenorhabditis elegans
6226711   156 rlVTSVRLTYTEFIAVTAYQNDAVIKLKIKFNPFAKGFREGSQS 199  Caenorhabditis elegans
2501136   240 qiVATAKFPHTEFIAVTAYQNQKITDLKIKHNSFAKGFRDGNLS 283  Caenorhabditis elegans
BAA34230  466 tnLRTFIIPKTRFMTVTLYHNTDVAQLKINLNPFARCFRDKEIS 509  Halocynthia roretzi

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