1MKX,1AUT,1BRU,1EKB,1A0L,1PPG,1C1M,1FUJ,1EX3,1TGB,1NPM,1PYT,1A5I,1BIT,1PFX,1KIG,1BUI,1TON,1PYT,1EJN,1FDP,1KLT,1AZZ,1TRY,1AU8,2HLC,1AE5,1SGT


Conserved Protein Domain Family
Tryp_SPc

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cd00190: Tryp_SPc 
Click on image for an interactive view with Cn3D
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Statistics
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PSSM-Id: 238113
View PSSM: cd00190
Aligned: 177 rows
Threshold Bit Score: 124.696
Threshold Setting Gi: 476147
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:catalytic triad for serine proteases
  • Citation:PMID 8140095

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                         #                           
1MKX_K     50 IVEGQDaev----glSPWQVMLFrks-----pqeLLCGASLISd-RWVLTAAHCLlyppwdknftvddLLVRIGKHSRtr 119 Bos taurus
1BUI_A     21 VVGGCVahp----hsWPWQVSLRtrf------gmHFCGGTLISp-EWVLTAAHCLeksp-----rpssYKVILGAHQEvn 84  human
1644281    27 IVGGEEaia----heFPYQISLQwnynndeqdpfHFCGGSLIAe-KFVLTAGHCVpsais----pdgfPEAVAGEHDFsq 97  African malaria mo...
1336053    26 IVGGDEaea----heFPYQISLQwnfndgqtetmHFCGASVLNe-NFVLTAAHCKtays-----ntgfIEVVAAEHDVav 95  yellow fever mosquito
117613      1 IVGGTDapr----gkYPYQVSLRap--------kHFCGGSISK--RYVLTAAHCLvgks------khqVTVHAGSVLLnk 60  European hornet
2765010    32 IIGGTEani----snFPWQVSVEsa-------gdHTCGGSLISp-DWVLTFSLCLdgfs-----gvfeHLLQFVSLRAgt 94  Schistocerca gregaria
2326314   335 INEDFRaey----geFPWMVALFqlp-----eqrYCCNGALIDp-KAILTTAHCVtncgg----raanIMVRFGEWNMss 400 African malaria mo...
2833332    33 VVGGEVakn----gsAPYQVSLQvpg------wgHNCGGSLLNd-RWVLTAAHCLvgha------pgdLMVLVGTNSLke 95  African malaria mo...
2833284    50 IVGGSVase----gqFPHQVALLrg-------naLTCGGSLIEs-RWVLTAAHCVyn---------gaLVVPASSIVVva 108 African malaria mo...
476147     51 IVGGREvddydedtgVHFIAKLFlpd-----gngFYCSGSVISksGHVLTRAGCEpr---------vnDVVRLGGSRLyn 116 Porphyra purpurea
Feature 1                                   #                                                 
1MKX_K    120 ye--rkveKISMLDKIYIHpRYnwkenldRDIALLKLkrPIELsdyiHPVCLPDkqtaaklLHagFKGRVTGWGNRretw 197 Bos taurus
1BUI_A     85 le---phvQEIEVSRLFLEpTR-------KDIALLKLssPAVItdkvIPACLPSpn---yvVAdrTECFITGWGETqgt- 150 human
1644281    98 yd---agvQRRRIAEMYVHeDYegs-vgpNDIAIFRVdkPFHLnrniQLVSLPEp-----nAIptGETTISGWGSTsfsf 168 African malaria mo...
1336053    96 ae---gseQRRLVAEFIVHeDYqgg-vspDDIAVIRVdkPFELndkvKAVKLPKq-----lEQfdGDVTLSGWGSVsttv 166 yellow fever mosquito
117613     61 ------eeAVYNAEELIVNkNYnsi-rliNDIGLIRVskDISYtqlvQPVKLPVsn----tIKagDPVVLTGWGRIyvn- 128 European hornet
2765010    95 stk-gsggVVLLAAEMYEHpLYipl-tvdYDVALIKVngSFALgpnvQAVSLPEqg---ydPPvgLPVTITGWGYNvtd- 168 Schistocerca gregaria
2326314   401 themaiprEDIGVKSVHQHpRYsps-allNNIAVLELahPVQYqatiQPVCLPSan---qpLRamENMIATGWGRVmeen 476 African malaria mo...
2833332    96 ------ggELLKVDKLLYHsRYnlp-rfhNDIGLVRLeqPVQFselvQSVEYSEk-----aVPanATVRLTGWGRTsan- 162 African malaria mo...
2833284   109 gsvslsngVRRAVARVITHeRYgn---fkNDVALLQLqlSLPSsayiRPIALRTs-----sVPagSEVVISGWGVCtkv- 179 African malaria mo...
476147    117 -------gVVARVAKVSIHpKYdpa-gevADVAVLKLkgVSESrl-lRAGVVPVfln--rvWDnpHGMYFTGYGATdkaa 185 Porphyra purpurea
Feature 1                                                                         #           
1MKX_K    198 ttsvaevqPSVLQVVNLPLVERpVCkastr------------iritdNMFCAGYkpgegkrGDACEGDSGGPFVMKspy- 264 Bos taurus
1BUI_A    151 ------fgAGLLKEAQLPVIENkVCnryefl----------ngrvqsTELCAGHla---ggTDSCQGDSGGPLVCFek-- 209 human
1644281   169 ----epsyPNILMKTTLPIMDLeVCrkiyft-----------etvadSNICAGTme---gtSSVCSGDSGGPLVQIdd-- 228 African malaria mo...
1336053   167 ----fpdyPDKLRKVVLPLVDYeQCdtlwgn----------dsalakSNVCAGPid---gsKSACSADSGGPLVKQsg-- 227 yellow fever mosquito
117613    129 -----gpiPNNLQQITLSIVNQqTCkfkhw-------------gltdSQICTFTkl----gEGACDGDSGGPLVAN---- 182 European hornet
2765010   169 -----gslSSVLQKVDVNIVDRaVCqatyvi-----------rnvtaRMVCAGEl-----lRGSCDGDFGXPLVSG---- 223 Schistocerca gregaria
2326314   477 -----appTQILKRLDLQRMEPsICrealrrvrr-----pypfildsSFVCSTTnhg--dqERPCDGDAGAPVVVElpgt 544 African malaria mo...
2833332   163 -----gpsPTLLQSLNVVTLSNeDCnkkggd----------pgytdvGHLCTLTkt----gEGACNGDSGGPLVYE---- 219 African malaria mo...
2833284   180 -----apyQTCFDTTVLPVVADqQCrdpt--------------gistGLICFTSpv----nNGACNGDSGGPAILN---- 232 African malaria mo...
476147    186 ----qsagSLTLKRAYLPVAPWwNCrritdtvvvpglsrpglpispaAQVCLRGgr---gaGALCERDPGGPMYRVsthr 258 Porphyra purpurea
Feature 1                                                   
1MKX_K    265 -nnrWYQMGIVSWGEg------CdrdgKYGFYTh-VFRLKKWIQKV 302 Bos taurus
1BUI_A    210 --dkYILQGVTSWGLg------CarpnKPGVYVr-VSRFVTWIEGV 246 human
1644281   229 ---eIVQVGIVSWGGi-----pCggykNPGVFVr-VSYFIDWINDK 265 African malaria mosquito
1336053   228 --eeVIQVGVVSWGAv-----pCgsprRPTVFAg-VSHYVDWIEQQ 265 yellow fever mosquito
117613    183 ----GVQIGIVSYGHp------Cav-gSPNVFTr-VYSFLDWIQKN 216 European hornet
2765010   224 ----STQVGVLSWTLf-----pCe--lGLDVYAn-VVSFRSWISEV 257 Schistocerca gregaria
2326314   545 -tnrYYLHGLVSWGYg------ChqkqIPYTVLtkVVHFREWIDRI 583 African malaria mosquito
2833332   220 ----GKLVGVVNFGVp------Cal-gYPDGFAr-VSYYHDWVRTT 253 African malaria mosquito
2833284   233 ----NQLVGRPNFIIn-----yCgs-aSPDGYAk-VSDFVTWIQTT 267 African malaria mosquito
476147    259 gvkiYTLYAVSSYWIglgadnrCpr-aMPNVGSk-VAFYYSWIQNQ 302 Porphyra purpurea

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