3AIG,1IAB,1ZXC,1BUD,2CKI,1MMR,1SMP,1KAP


Conserved Protein Domain Family
ZnMc

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cd00203: ZnMc 
Click on image for an interactive view with Cn3D
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.
Statistics
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PSSM-Id: 238124
Aligned: 17 rows
Threshold Bit Score: 82.1847
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1SMP; Serratia marcescens metalloproteinase with coordinated zinc
    View structure with Cn3D
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3AIG           6 RYIELVVvadrrvfmky--nsdlniirtRVHEIVNIINEFYrs------------------lnIRVSLTdleiwsgqdfi 65   eastern diamon...
BAD95447      86 VEIPFVLsde---------------ydhNEKNQILKAMKGFegr-----------------tcIRFVRHrge-------- 125  killifish
P25723       149 GVIPYEIdti---------------fsgAHKALFKQAMRHWenf-----------------tcIKFVERdpnl------- 189  fruit fly
NP_005579     77 FPIPYILadn---------------lglNAKGAILYAFEMFrlk-----------------scVDFKPYege-------- 116  human
1IAB          13 GVIPYTFagv----------------sgADQSAILSGMQELeek-----------------tcIRFVPRtte-------- 51   broad-fingered...
2CKI_B         5 VKIPVVVhvvwnee-------eenisdaQIQSQIDILNKDFrklnsdvsqvpsvwsnliadlgIEFFLAtkdpngnqttg 77   Methanosarcina...
ZP_00054902   99 NGVTLTVgfld-------------nppaDLRARILAHMNAWgty-----------------anTHFAESnv--------- 139  Magnetospirill...
ABG51092      82 FPIKVYVessdnd----------esrsrQWVKTVVDAIWEWniy-----------------lpLQVVDSpe--------- 125  Trichodesmium ...
1MMR          13 KVVTYRIvsytr-----------dlphiTVDRLVSKALNMWgke-----------------ipLHFRKVvwg-------- 56   human
1SMP_A        56 VKLTFSFpdykfsstnvagdtglskfsaEQQQQAKLSLQSWadv-----------------anITFTEVaag-------- 110  Serratia marce...
Feature 1                                                                                        
3AIG          66 tiqssssn-----tlnsfgewrervlltrkrhDNAQLLtainf--------egkiIGKAYtssmc-------------np 119  eastern diamon...
BAD95447     126 ------------------------------raYLSIESk---------------fGCFSLmgrs---------------g 145  killifish
P25723       190 -----------------------------hanYIYFTVkn--------------cGCCSFlgkn--------------gn 212  fruit fly
NP_005579    117 ------------------------------ssYIIFQQf---------------dGCWSEvgdq---------------h 136  human
1IAB          52 ------------------------------sdYVEIFTsg--------------sGCWSYvgri---------------s 72   broad-fingered...
2CKI_B        78 itrtqtsvtffttsdevkfassggedawpadrYLNIWVchvlks-----eigqdiLGYAQfpgg--------------pa 138  Methanosarcina...
ZP_00054902  140 ------------------------------dpQVRISRta-------------gdGYWSYlgtdvl----------tiga 166  Magnetospirill...
ABG51092     126 ------------------------------vaDIKIFNkrp------------plRAGNLrarsaearyqlsedengils 163  Trichodesmium ...
1MMR          57 ------------------------------taDIMIGFargahgdsypfdgpgntLAHAFapgt---------------g 91   human
1SMP_A       111 -----------------------------qkaNITFGNysqdrpg----hydygtQAYAFlpntiw----------qgqd 147  Serratia marce...
Feature 1                                     ##  #     #                                        
3AIG         120 rsSVGIVKdhspi-------nllvaVTMAHELGHNLGMEHDgkdcl---------------------------------- 158  eastern diamon...
BAD95447     146 erQLVSLQrpgc----------lnnGIIQHELLHAMGFYHEhtrsdrdkyvkinwdniqe------------yyyknfkk 203  killifish
P25723       213 grQPISIGrnc-----------ekfGIIIHELGHTIGFHHEhargdrdkhivinkgnimrgq--------eynfdvlspe 273  fruit fly
NP_005579    137 vgQNISIGqgc-----------aykAIIEHEILHALGFYHEqsrtdrddyvniwwdqilsgy--------qhnfdtydds 197  human
1IAB          73 gaQQVSLQangc----------vyhGTIIHELMHAIGFYHEhtrmdrdnyvtinyqnvdps----------mtsnfdidt 132  broad-fingered...
2CKI_B       139 etDGVVIVdaafgttgtalppfdkgRTATHEIGHWLNLYHIwgdelrfedpcsrsdevddtpnqa---dpnfgapsyphv 215  Methanosarcina...
ZP_00054902  167 dkATMNLDsftmnt-----rdsefyRVVRHETGHTLGFPHEhrrkeivdqidfekavayfmasqgwtrekvisqvltplq 241  Magnetospirill...
ABG51092     164 hnFVIWLSpmqvg--------kylpAAARHEFGHALGIWGHspek----------------------------------- 200  Trichodesmium ...
1MMR          92 lgGDAHFDederwtdg-sslginflYAATHELGHSLGMGHSsd------------------------------------- 133  human
1SMP_A       148 lgGQTWYNvnqsnvkh-patedygrQTFTHEIGHALGLSHPgdynagegnpty--------------------------- 199  Serratia marce...
Feature 1                                                                      
3AIG         159 -------rgasLCIMRPgltp-----------------------grsyEFSDDSMGYYQKFL 190  eastern diamondback rattlesnake
BAD95447     204 mdtdnltpydySSVMQYgktafgknraesit----pipdpnvpigqreGMSDTDILRVNKLY 261  killifish
P25723       274 evdlpllpydlNSIMHYaknsfskspyldtitpigippgthlelgqrkRLSRGDIVQANLLY 335  fruit fly
NP_005579    198 litdlntpydyESLMHYqpfsfnknasvptit--akipefnsiigqrlDFSAIDLERLNRMY 257  human
1IAB         133 ysryvgedyqyYSIMHYgkysfsiqwgvletivplqngidltdpydkaHMLQTDANQINNLY 194  broad-fingered crayfish
2CKI_B       216 scsngpngdxfXNYXDYvddk------------------------cxvXFTQGQATRVNACL 253  Methanosarcina acetivorans
ZP_00054902  242 dadlnatadadRTSIMCywlpgsimk-------------ngepvvggvDIDKVDADFAASIY 290  Magnetospirillum magnetotacticum...
ABG51092     201 -------tdvmYYSQVAep----------------------------pPISSRDINTLKRIY 227  Trichodesmium erythraeum IMS101
1MMR         134 ----------pNAVMYPtygng---------------------dpqnfKLSQDDIKGIQKLY 164  human
1SMP_A       200 ndvtyaedtrqFSLMSYwsetntgg---------------dngghyaaAPLLDDIAAIQHLY 246  Serratia marcescens

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