1EGW


Conserved Protein Domain Family
MADS_MEF2_like
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cd00265: MADS_MEF2_like 
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MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.
Links
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Statistics
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PSSM-Id: 238165
Aligned: 41 rows
Threshold Bit Score: 107.638
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1EGW_A, interaction of the N-terminal and alpha 1 helix with the major and minor grooves of the DNA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ### # #    # #   ##  ## ##  ## ##   #                                          
1EGW_A      1 GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDM--DKVLLKYTEYNEPHES 77  human
P35631      2 GRGRVQLKRIENKINRQVTFSKRRAGLLKKAHEISVLCDAEVALVVFSHKGKLFEYSTDSCm-EKILERYERYSYAERQ 79  thale cress
NP_195377   7 GRQKIEMKKMENESNLQVTFSKRRFGLFKKASELCTLSGAEILLIVFSPGGKVFSFGHPSV--QELIHRFSNPNHNSAI 83  thale cress
T10764      2 GRGRIRLRKIESATSRQVTFSKRKNGLLKKAYELSVLCDVELGLIVLSPRGKVHEFSSTCM--QKMLERYEKCSEGSKT 78  Monterey pine
BAA81885    3 RRGRVQLRRIEDKASRQVRFSKRRAGLFKKAFELALLCDVEVALLVFSPVGKLYEYSSSSI--EGTYDRYQQFAGARRD 79  Oryza sativa (japon...
BAB63832   16 GRQKIEIRRIESEEARQVCFSKRRAGFFKKASELSILCSADVAAVVFSPAGKAYSFGHPSV--ECLLERFLPDSSSGAA 92  Oryza sativa (japon...
Q9S7Q7      2 GRKKLEIKRIENKSSRQVTFSKRRNGLIEKARQLSVLCDASVALLVVSASGKLYSFSSGDNl-VKILDRYGKQHADDLK 79  thale cress
NP_174399   2 RKGKRVIKKIEEKIKRQVTFAKRKKSLIKKAYELSVLCDVHLGLIIFSHSNRLYDFCSNSTsmENLIMRYQKEKEGQTT 80  thale cress
BAA85629    2 TKTKLQLSRIESSTRRKVTFSKRRNGLLKKAFELSVLCDADIALLVFSESGKLHQFSNPEM--NMIITRYKSFIQRHGD 78  Gnetum parvifolium
Q12224      2 GRRKIEIQRISDDRNRAVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEFSSVDT--NDLIYHYQNDKNLLHE 78  baker's yeast

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