1CM9,1HA6,1NCV,1EOT,1DOL,2HCC,1EIG,1HRJ,1G2S,1EL0,1NR2,1HFG


Conserved Protein Domain Family
Chemokine_CC

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cd00272: Chemokine_CC 
Click on image for an interactive view with Cn3D
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.
Statistics
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PSSM-Id: 238170
View PSSM: cd00272
Aligned: 41 rows
Threshold Bit Score: 56.484
Threshold Setting Gi: 1778606
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:monomeric unit which assembles to form the tetrameric structure; to view the tetramer please see PMID 8989326
  • Comment:composed of both types of dimer interfaces (I and P forms)
  • Citation:PMID 8989326
  • Comment:some members of the CXC subgroup also forms tetramers

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       # #              # #      #    ###         ###     ##  ##  ##
1CM9_A     14 CCLGYq-KRPLPQVLLS-SWYPTSq--LCsKPGVIFLTk--RGRQVCADKSKDWVKKLXQQLP 70  unclassified viruses
1NCV_A     11 CCYRFi-NKKIPKQRLE-SYRRTTs-sHCpREAVIFKTk--LDKEICADPTQKWVQDFMKHLD 68  human
1NR2_A     10 CCLEYf-KGAIPLRKLK-TWYQTSe--DCsRDAIVFVTv--QGRAICSDPNNKRVKNAVKYLQ 66  human
O15467     37 CCLKYy-EKVLPRRLVV-GYRKAL---NChLPAIIFVTk--RNREVCTNPNDDWVQEYIKDPN 92  human
AAC56951   37 CCENSlsSARLPPDKLIcGWYWTSt-vYCrQKAVIFVTh--SGRKVCGSPAKRRTRLLMEKHT 96  Kaposi's sarcoma-associated herpesv...
Q99731     29 CCLSVt-QKPIPGYIVR-NFHYLLikdGCrVPAVVFTTl--RGRQLCAPPDQPWVERIIQRLQ 87  human
AAF23861   29 CCLKFt-QHPVHCRWLK-GYTFQDitsSCdLNAVIFQNr--RNKFVCADPSQDWTKRVQRCLR 87  coho salmon
O00585     31 CCLKYs-QRKIPAKVVR-SYRKQEpslGCsIPAILFLPrkrSQAELCADPKELWVQQLMQHLD 91  human
CAC45063   33 CCTKVs-KQKITVPIIGaRLQRKAl--PC-VNAVIFETd--NGETICSHWKESWVRKAFFQLE 89  rainbow trout
AAO21203   27 CCLGYv-REIKKKRNLV-SYTMQEtdgDCnIRAVLFKWk-kREQPVCANPNDHWVQKEMRRLD 86  golden mbuna

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