1FTA,1DCU,1FRP,1SPI


Conserved Protein Domain Family
FBPase

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cd00354: FBPase 
Click on image for an interactive view with Cn3D
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-biphosphatases that play a role in pentose phosphate pathway (Calvin cycle).
Statistics
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PSSM-Id: 238214
View PSSM: cd00354
Aligned: 61 rows
Threshold Bit Score: 271.348
Threshold Setting Gi: 11386864
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1FRP_A; FBPase - fructose-2,6-bisphosphate complex
    View structure with Cn3D
  • Comment:binds fructose-1,6-biphosphate or the inhibitor fructose-2,6-biphosphate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1FTA_A     17 VMEEGRKa---------rGTGELTQLLNSLCTAVKAISSAVRKagiahLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKS 87  human
1FRP_A     17 VMEQGRKa---------rGTGEMTQLLNSLCTAVKAISTAVRKagiahLYGIAGATNVTGDQVKKLDVLSNDLVINVLKS 87  pig
P46283     76 IGQSLEEf---------lAQATPDKGLRTLLMCMGEALRTIAFkvrtaSCGGTACVNSFGDEQLAVDMLADKLLFEALQY 146 thale cress
P46284     75 IGDSLAEf---------lVEATPDPKLRHVMMSMAEATRTIAHkvrtaSCAGTACVNSFGDEQLAVDMVADKLLFEALKY 145 Chlamydomonas rein...
CAC70746   12 ITDTLRKa---------gVPCDVVGIVETVAGACRAIAAGLRNd----GVTAAKSKNNFGDDVLSVDVMADKIISEALNS 78  Trypanosoma brucei
AAO22558   74 IGDSLEEf---------lTKATPDKNLIRLLICMGEAMRTISFkvrtaSCGGTACVNSFGDEQLAVDMLADKLLFEALEY 144 Indian rice
AAP79184  110 IEEFLAN-----------TEPKLQKAIMGMFSACKEIGYKIRTa----SCDKQACFNAFGDEQLAIDVLADNVIFENLRA 174 Bigelowiella natans
XP_323836  21 LTTHLASllp-----sssRDSLRTSVLPSLLTSIAATSTALRAa---qDVSLAGSSNSFGDDQLNVDVLAEEAIRLCLAQ 92  Neurospora crassa
EAA53425    9 LDSAAFRsyldslvpstaRAELTGSVLPALVHAIGDVSALLRRa---hTVAHVGTTNAFGDQQLNVDLAADDVIRAACKS 85  Magnaporthe grisea...
NP_952702  12 QVDLRRHl----------RNQDISDNLVHLICEIAEASKYVINavrtgDLGVAGTSNLYGEEQLALDVLSDRIIRKRLIH 81  Geobacter sulfurre...
Feature 1                                                     # ##                            
1FTA_A     88 SfatcVLVSEEDKHAIIVepe---------------krGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKkstdepsekda 152 human
1FRP_A     88 SfatcVLVTEEDKNAIIVepe---------------krGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKnstdepsekda 152 pig
P46283    147 ShvckYACSEEVPELQDMggp---------------veGGFSVAFDPLDGSSIVDTNFTVGTIFGVWPGdklt------- 204 thale cress
P46284    146 ShvckLACSEEVPEPVDMg------------------gEGFCVAFDPLDGSSSSDTNFAVGTIFGVWPGdklt------- 200 Chlamydomonas rein...
CAC70746   79 CqhvaSYVSEESPSLASTahs---------------gkATHSVSYDPLDGSSIITSNFTVGSIFAVWPGntpi------- 136 Trypanosoma brucei
AAO22558  145 ShvckYACSEEVPELQDMggp---------------vdGGFSVAFDPLDGSSIVDTNFTVGTIFGVWPGdklt------- 202 Indian rice
AAP79184  175 SgavaTASSEEEPTEVPLg------------------gEGYSVAFDPLDGSSIIDTNFAVGTIFGNLGLdprl------t 230 Bigelowiella natans
XP_323836  93 Cps-vVTASSEEDPIEKPvqhtglpfqvveaeqdrthgEVYTVAFDPLDGSSIIAPNWTVGTIFSLWDGtsal------g 165 Neurospora crassa
EAA53425   86 CpsvvTASSEEVPIEEALrsgevd---------aagssERYTVAYDPLDGSSIIAPNWTVGAILGVWDGatal------g 150 Magnaporthe grisea...
NP_952702  82 SgvvcNIASEEMDEIFQAqad---------------adGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGcnl-------- 138 Geobacter sulfurre...
Feature 1                                                                                     
1FTA_A    153 lqpGRNLVAAGYALYGSATMLVLAMd------CGVNCFMLDPa------IGEFILVDkd---------vkIKKKGKIYSL 211 human
1FRP_A    153 lqpGRNLVAAGYALYGSATMLVLAMv------NGVNCFMLDPa------IGEFILVDrn---------vkIKKKGSIYSI 211 pig
P46283    205 gitGGDQVAAAMGIYGPRTTYVLAVkg----fPGTHEFLLLD-------EGKWQHVKet----------tEIAEGKMFSP 263 thale cress
P46284    201 nitGREQVAAGMGIYGPRTVFCIALkd----aPGCHEFLLMD-------DGKWMHVKet----------tHIGEGKMFAP 259 Chlamydomonas rein...
CAC70746  137 gltVRDMVASVVAVYGPRVVLFVGQe-----eLGVAEFFCGAdgewklaKRVWAGVCtprtatvtaagrgVKLKATVFSP 211 Trypanosoma brucei
AAO22558  203 gvtGGDQVAAAMGIYGPRTTYIIALkd----cPGTHEFLLLD-------EGKWQHVKdt----------tTIGEGKMFSP 261 Indian rice
AAP79184  231 gikGTEQKAAGLGVYGPRTTITLAVdg----iQGAHEFLLIDdys--akHGQWVLSQsf----------mSIGESKLFAP 294 Bigelowiella natans
XP_323836 166 aspRDKQIGAVLGVYGPRTTAVVALrfpgeekGVCFEVGLSDss----eAGKGQEWD-------------LIRPSVSYAP 228 Neurospora crassa
EAA53425  151 qspRRSMVAAILGVFGPRTTAIVALr-----vPGIGEPACFE-------LGIDGESLt------------MVQPNIRLAS 206 Magnaporthe grisea...
NP_952702 139 lqkGRNQVAAMYILYGPRVSLVYSVg------KGVHEFTMNH-------LMEYTLSRen---------vtMKPDGDIYSP 196 Geobacter sulfurre...
Feature 1        #                                          ##   #                #         # 
1FTA_A    212 neaYAKD----------FDPAVTEYIQRKKFPpdn-----saPYGARYVGSMVADVHRTLV-YGGIFLYPAnkkspnGKL 275 human
1FRP_A    212 negYAKE----------FDPAITEYIQRKKFPpdn-----saPYGARYVGSMVADVHRTLV-YGGIFMYPAnkkspkGKL 275 pig
P46283    264 g--NLRAt---------FDNSEYSKLIDYYVKe---------KYTLRYTGGMVPDVNQIIVkEKGIFTNVTspt-akAKL 322 thale cress
P46284    260 g--NLRAt---------FDNPAYERLINFYLGe---------KYTLRYTGGIVPDLFQIIVkEKGVFTNLTspt-tkAKL 318 Chlamydomonas rein...
CAC70746  212 g--NLRAa---------RHLPWYKQLITMYMQe---------GATLRYTGGMVPDVCQIIVkGDGIYMTPAspq-hkMKL 270 Trypanosoma brucei
AAO22558  262 g--NLRAt---------FDNPEYDKLINYYVKe---------KYTLRYTGGMVPDVNQIIVkEKGIFTNVTspt-akAKL 320 Indian rice
AAP79184  295 g--NLRAt---------KDNKGYEELFNYWYDn---------QYQLRYTGGMVPDVNQIMVkGKGVFVNAEska-akAKL 353 Bigelowiella natans
XP_323836 229 ppfKTRYfapanlrstnTHAAYAKLVAHYMAE----------NYTLRYCGGLVPDVVHALVkGHGVYLSPVtet-skAKL 297 Neurospora crassa
EAA53425  207 pplNTRY----------FAPANLRAAAECDKYsalvshfisqKYTLRYSGGLVPDVVHALVkGHGVYISPTtpq-saGKL 275 Magnaporthe grisea...
NP_952702 197 gglRKKY----------LPETEKFVQHLESKG----------SKLRYSGGFVPDINQVLMK-GKGIFMYPAlngspnGKL 255 Geobacter sulfurre...
Feature 1                                                                
1FTA_A    276 RllYECNPMAYVMEKAGGMATTGK---EAVLDVIPTDIHQRAPIILGSPDDVLEFLKVY 331 human
1FRP_A    276 RllYECNPMAYVMEKAGGLATTGK---EAVLDIVPTDIHQRAPIILGSPEDVTELLEIY 331 pig
P46283    323 RllFEVAPLGLLIENAGGFSSDGH---KSVLDKTIINLDDRTQVAYGSKNEIIRFEETL 378 thale cress
P46284    319 RilFEVAPLALLIEKAGGASSCDGk-aVSALDIPILVCDQRTQICYGSIGEVRRFEEYM 376 Chlamydomonas reinhardtii
CAC70746  271 RllFEAAPMAFLIHCAGGRSTTGL---TNMMNVRVVSMEQTTPIALGCARDVERYERMC 326 Trypanosoma brucei
AAO22558  321 RllFEVAPLGFLIEKAGGYSSDGK---QSVLDKVINNLDERTQVAYGSKNEIIRFEETL 376 Indian rice
AAP79184  354 RllYEVAPIGYVIEKAGGKSSDGE---QSVLNIEVVGTEDRTQVAYGSAAEVDRFEQMV 409 Bigelowiella natans
XP_323836 298 RslYELFPLALVVECCGGRAVDPVsgeNILGDKGVEGCDERGGIVCGTAEEVEYAKEVL 356 Neurospora crassa
EAA53425  276 RrlYELSPIALVVECAGGKAVDSSs-gVGVLDVTISDCDERGGVICGNNIEVDLASKYL 333 Magnaporthe grisea 70-15
NP_952702 256 RvlFELNPMAYLIENAGGAATDGK---TPILDIEPQSLDQRAPIFIGCSNDVATAMEFM 311 Geobacter sulfurreducens PCA

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