1B76


Conserved Protein Domain Family
GlyRS_anticodon
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cd00858: GlyRS_anticodon 
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GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.
Links
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Statistics
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PSSM-Id: 238435
Aligned: 32 rows
Threshold Bit Score: 160.031
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodon
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Comment:based upon similarity with ProRS anti-codon binding domain interaction
  • Citation:PMID 9493271
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       ##                                     #     #
1B76_A    313 FTREELp----nGEERIVLKLKPQLAPIKVAVIPLVknrPEITEYAKRLKARLLALglGRVLYEDTGNIGKAYRRHDEVG 388 Thermus thermophilus
NP_613439 444 VLEHNF------DPEEGVFRFPAWLAPIEVGVFPLLk-rSDMVEYARRVARMLREEg-FTVEYDDSGSIGRRYARADEIG 515 Methanopyrus kandl...
2500998   459 LLEHSYr----eEEDRVYLDLKPSIAPIKAYVLPLVn-kDDMPKIAKEIEQMLRENg-IIAEYDDSGAIGRRYMRADEIG 532 Methanocaldococcus...
3334354   434 VLEHAFdkdvvdGEERRVLRLKRWVSPIEVAVLPLLs-rEPFESKGMEIVQMLREEg-IFTDYDDSGSIGRRYRRFDEIG 511 Archaeoglobus fulg...
11387160  451 ALEYAYr----eVEGRVVLAFPRDIAPVQAVVLPLVendEKLVERARMVYETLVEAg-FTVYYDDSGSIGRRYARADEIG 525 Aeropyrum pernix
NP_280974 447 ALAHSYeadevdGEPRDVLRLPAEVAPTTVGVFPLMd-kDGLGERAREIAAELRAAg-LAVTYDDSGNIGRRYRRQDEVG 524 Halobacterium sp. ...
11387128  451 LLENSLtv---dEDGRIYLKIKKDMAPIEVAVLPLVa-kEPLTTIAYEIYRTLQKEg-FIVVYDEKDSIGKRYMRYDEIG 525 Pyrococcus horikoshii
3334352   448 LLLHSLv----dDGERTYFRLPPHVAPVEVTVLPLVn-rEEMVMTALEIERNLRRSg-FIAEFDSSGTIGRRYARADEIG 521 Methanothermobacte...
NP_111907 350 ILNDGYyi---rDNGYKVLKLDPAVSPLHFAVFPLQr-rDGLDAKAKELFNKIKQId-PFVYYDEGGNIGRRYARQDEIG 424 Thermoplasma volca...
NP_559891 452 VLESAVv----eEEGRVYLRLPPDIAPVKACILPIVk-rADYVEIGRTLWRSLARQg-FVVLYEDEGTIGSRYASCDEIG 525 Pyrobaculum aeroph...

Feature 1            #                  # #                        
1B76_A    389 TPFAVTVDYDTigqskdgttrlkdTVTVRDRDTMEQIRLHVDELEGFLRERLR 441 Thermus thermophilus
NP_613439 516 VPYCVTVDHETle---------ddTVTIRDRDTTEQVRVEVDELADVLRGLID 559 Methanopyrus kandleri AV19
2500998   533 VPFCITVDGQTle---------drTVTVRERNTREQVRVKIDELVDYLKERLK 576 Methanocaldococcus jannaschii
3334354   512 TPFCVTVDHQTfe---------deTVTIRDRDTTAQVRVKLGELPSILKELLR 555 Archaeoglobus fulgidus
11387160  526 VPAAVTIDYQTle---------dgTVTLRDRDTWRQVRIGADEVVDKLRRFIY 569 Aeropyrum pernix
NP_280974 525 TPYCVTVDYEAle---------egAVTLRDRDTTTQVRVPIAEVAETLVGLRD 568 Halobacterium sp. NRC-1
11387128  526 TPYCVTVDNQTpe---------dgTVTIRDRDTREQIRVKIEELPRKLKELIF 569 Pyrococcus horikoshii
3334352   522 VPFAVTVDHETle---------dgTVTLRNRDDCSQVRVKIEELVPTLEKLRG 565 Methanothermobacter thermautotrophicus
NP_111907 425 TPFCITVDYETle---------dsTVTIRERDSTKQVRENIEELLQKISDYPE 468 Thermoplasma volcanium
NP_559891 526 TPLAVTIDEKTpv---------dgTVTIRDRDTKRQVRVKLGDVVTFVSMVAG 569 Pyrobaculum aerophilum str. IM2

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