Conserved Protein Domain Family
MD-1_MD-2

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cd00915: MD-1_MD-2 
MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS); MD-2 directly binds the lipid A moiety of LPS. The TLR4-like receptor, RP105, which mediates LPS-induced lymphocyte proliferation, interacts with MD-1; MD-1 enhances RP105-mediated LPS-induced growth of B cells. These proteins belong to the ML domain family.
Statistics
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PSSM-Id: 238457
Aligned: 3 rows
Threshold Bit Score: 207.03
Threshold Setting Gi: 20138467
Created: 5-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity of conserved residues

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #       # # #                  #     # # #            # # #             #       
O95711     30 HVVCSDSGLEVLYQSCDplqd-fgfsVEKCSKQLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPICEAALPK 108 human
P58755     22 LWFCNSSDATFSYSYCDsmkfpfsitAEPCITLKGTNGFLHIKFIPRRDLKKLYFNLSINVNSIEVPTRKEIICHGYDDN 101 Chinese hamster
Q90890     25 HTVCKEENLEIYYKSCDpqqd-fafsIDRCSDVTTHTFDIRAAMVLRQSIKELYAKVDLIINGKTVLSYSETLCGPGLSK 103 chicken
Feature 1          #       #                # # # #       #  # # #
O95711    109 FSFCGRRKGeQIYYAGPVnnpefTIPQGEYQVLLELYTe-kRSTVACANATI 159 human
P58755    102 YSFCKALKGeTVNTVVPFsfkgiLFPKGQYRCVAEAIVgdnEEKLFCLNFTI 153 Chinese hamster
Q90890    104 LIFCGKKKGeHLYYEGPItlgikEIPQRDYTITARLTNe-dRATVACADFTV 154 chicken

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