1NEP


Conserved Protein Domain Family
Npc2_like

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cd00916: Npc2_like 
Click on image for an interactive view with Cn3D
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Although Npc2 is known to bind cholesterol, the function of this protein is unknown. These proteins belong to the ML domain family.
Statistics
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PSSM-Id: 238458
View PSSM: cd00916
Aligned: 24 rows
Threshold Bit Score: 110.091
Threshold Setting Gi: 31241355
Created: 5-Feb-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative cholesterol/lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                               #     
1NEP_A      5 FKDCGSWv------GVIKEVNVSPCPt------qPCKLHRGQSYSVNVTFTSNTQSQSsKAVVHGIVM-GIPVPFPIp-e 70  cow
Q9VQ62     21 FSDCGSKt------GKFTRVAIEGCDtt----kaECILKRNTTVSFSIDFALAEEATAvKTVVHGKVL-GIEMPFPLa-n 88  fruit fly
O17271     22 YKVCKSD-------GTVSQVKADGCEltvkdgkkVCLFKKGSRPIIQIAFKPSKDTDKlKTSVRAKVGgSAMVDFPQt-n 93  nematode
Q9DGJ3     24 FVDCGSVd------GKVVQVDIKPCSq------qPCKLHKGQSYTVNVTFSSGVESQTsKAVVHGVLA-GVPVPFPIp-i 89  zebrafish
Q25481     19 YTDCGSKl------ATVQSVGVSGWPen----arECVLKRNSNVTISIDFSPTTDVSAiTTEVHGVIM-SLPVPFPCr-s 86  tobacco hornworm
AAH60392   25 YKDCGSQs------GKLTLLDVSPCPe------qPCPLKRGDTYTINATFISNVNSKSaTAVVHGIIM-GIPAPFPIs-e 90  African clawed frog
AAF57082   26 FQTCEDSvd----sCSISQVRVTPCPean--anaACHIRRRHRFTMSFDFTPHFDADTlVASLGWAKSeNVELPLLTm-d 98  fruit fly
BAA89306   25 TRLCREVda---saCTVNEVRIDPCVns-----rLCHLKKGKNAKVSFDFTPQFSTTKlKTGLFGLKN-GAEIPFDAlyn 95  domestic silkworm
XP_392711  70 WRQCPYPdpniqtnCTIHEVYIDPCKeit--egkPCKIKRGVIGNMTFHYTPAFSSDKvQGRIFWASQ-VMDIPFLGm-n 145 honey bee
XP_320500  60 FANCANEta----iGKYTQVEVSNCAds----dnSCVLKRNSNATISITFTSGEDLSElKAVVHGIIL-GMEVPFKLp-n 129 Anopheles gambiae ...
Feature 1                               #   #                            
1NEP_A     71 SDGCKsg-iRCPIEKDkTYNYVNKLPVKnEYPSIk-VVVEWELTDd-kNQRFFCWQIPI 126 cow
Q9VQ62     89 PDACVdsglKCPLEKDeSYRYTATLPVLrSYPKVs-VLVKWELQDq-dGADIICVEIPA 145 fruit fly
O17271     94 SDACTyg-vKCPVSAGeNQIFEQSISITeNHPAGevIQVNWQLTRp-dSGKEVCIIFLA 150 nematode
Q9DGJ3     90 DDGCKsg-iQCPIVPQkPYNYVTELPVKtEYPAIk-VVVEWELRDd-sSKDLFCIKFPV 145 zebrafish
Q25481     87 PDACKdnglTCPIKAGvVANYKTTLPVLkSYPKVs-VDVKWELKKd--EEDLVCILIPA 142 tobacco hornworm
AAH60392   91 PDGCKtg-iSCPINSGqTYTYLTKLPIKsEYPCIk-LVVKWQLQDe-nNQNLFCWLLPV 146 African clawed frog
AAF57082   99 QEACKy--tTCPVRSGvTQTYTNNMPADaRFPLSp-YTIRWALKDp-vSQKRCCFTIDI 153 fruit fly
BAA89306   96 ADACTl--tSCPTEAGkTQTLDFSSHIGkKLPTGn-FEFKWKLWNednESQMCCYRTNV 151 domestic silkworm
XP_392711 146 PDACLs--tSCPIEAGsRNTYHVEIPILkKYPVRt-YDLKWKIWNd--EEQECCFMFQI 199 honey bee
XP_320500 130 DDGCKdsglECPLTKDtSYRYSTTLPVLkQYPKVs-VEVKWELKAg--DKDVLCVLIPA 185 Anopheles gambiae str. PEST

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