Conserved Protein Domain Family
PDZ_LON_protease
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cd00986: PDZ_LON_protease (this model, PSSM-Id:238486 is obsolete)
PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ domains a C-terminal beta-strand is thought to form the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.
Links
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Statistics
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PSSM-Id: 238486
Aligned: 5 rows
Threshold Bit Score: 106.39
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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protein binding
Feature 1:protein binding site [polypeptide binding site]
Evidence:
  • Comment:contains the GLGF loop, a carboxylate-binding motif
  • Comment:PDZ binds to either the terminal COOH group of a peptide ligand (1KWA) or an internal peptide sequence that mimics the PDZ binding motif (1QAV)
  • Citation:PMID 8674113
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #### #                                  ##  ##                                
NP_243452 124 RPVDYTYHGVLVTQVIDGMPAAEKLKAGDHIIAVDDEPVLEADELLEKLQGRTEGETVKLTVKREege-pfDVILTFEP 201 Bacillus halodurans
NP_692374 122 ETIDISYEGVYVVSVVEGMPAEEVLQAGDRIIGIDGKDIKESQDLIDYIDSLSAGDTVTVEVIRNdenlskKIQLEQFS 200 Oceanobacillus ihey...
NP_389388 121 KKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQSAEKLIDYISSKKAGDKVTLKIEREekekrvTLTLKQFP 199 Bacillus subtilis s...
NP_657963 122 RTVSFENKGVLVAGVAKGMPSEGKLKLGDVIIAVDGKTFEKTEQFIEYMTGEKEGDTVNIEYKRDgkqlkeNLNVKTIP 200 Bacillus anthracis ...
NP_471491 122 QKVKVTYDGVYVLSVKEDVPAAGILHAGDLITEIDGQSFKSSQEFIDYIHSKKVGDTVKIKYKHGnkn-eeASIKLTAI 199 Listeria innocua

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