3PDZ,1B8Q,1I16,1I92,1IHJ,1KWA,1L6O,1M5Z,1N7T,1N99,1N99,1NF3,1PDR,1QAV


Conserved Protein Domain Family
PDZ_signaling

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cd00992: PDZ_signaling 
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PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.
Statistics
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PSSM-Id: 238492
View PSSM: cd00992
Aligned: 291 rows
Threshold Bit Score: 40.6279
Threshold Setting Gi: 17538778
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
protein binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:protein binding site [polypeptide binding site]
Evidence:
  • Comment:contains the GLGF loop, a carboxylate-binding motif
  • Comment:PDZ binds to either the terminal COOH group of a peptide ligand (1KWA) or an internal peptide sequence that mimics the PDZ binding motif (1QAV)
  • Structure:1KWA; CasLIN-2 PDZ and C-terminal polypeptide ligand complex
    View structure with Cn3D
  • Citation:PMID 8674113
  • Structure:1QAV; Syntrophin PDZ - Nnos complex
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #### #                                               
3PDZ_A       6 IFEVELAKn----------------dNSLGISVTGgvnts----vrhggIYVKAVIpQGAAesdgrIHKGDRVLAVNGVS 65   human
1KWA_A       2 SRLVQFQKnt---------------dEPMGITLKMnel---------nhCIVARIMhGGMIhrqgtLHVGDEIREINGIS 57   human
NP_055722   55 RHTVKIDKdt--------------llQDYGFHISEsl-----------pLTVVAVTaGGSAhg--kLFPGDQILQMNNEP 107  human
NP_570613   16 YRQITIPRg----------------kDGFGFTICCds-----------pVRVQAVDsGGPAer-agLQQLDTVLQLNERP 67   human
NP_731964   61 PRQVQLQRna---------------sLGFGFVAGSer-----------pVIVRFVTeGGPSig--kLQPGDQILAVNGED 112  fruit fly
NP_651110   24 VRLLRIPRaap-------------amENYGFQLTRskw--------dpyPWVCEVAaGTPAal-cgLKPGDCVLEVNGND 81   fruit fly
NP_648023  124 RRTIIVEKk----------------nNSYGFTLQSygihykrdeelemiTYVDYVEyGGPAyr-agMREGDVILSINGKD 186  fruit fly
BAA20774   133 PRKVEMRRdp---------------vLGFGFVAGSek-----------pVVVRSVTpGGPSeg--kLIPGDQIVMINDEP 184  human
XP_292955  278 VPAVEIRTagvqqriqlfcfrkclknKSFGPQRCCpgiy------faiaPQVQPVL-WQVSa----STKGDLPVNGIHVE 346  human
XP_294249  356 PRTVRVYKg----------------nKSFGFTLRGhg-----------pVWIESVLpGSPAdn-aaLKSGDRILFLNGLD 407  human
Feature 1                        ##  ##           
3PDZ_A      66 Leg----------atHKQAVETLRNTgqvVHLLLE 90   human
1KWA_A      58 Van----------qtVEQLQKMLREMrgsITFKIV 82   human
NP_055722  108 Aed----------lsWERAVDILREAedsLSITVV 132  human
NP_570613   68 Veh----------wkCVELAHEIRSCpseIILLVW 92   human
NP_731964  113 Vkd----------apRDHVIQLVRACesqVNLLVC 137  fruit fly
NP_651110   82 Vlg----------lrVSEIAKMVKSQkdcVTILCW 106  fruit fly
NP_648023  187 Mek----------adHKTIVEFIKQCdtrMRMVVL 211  fruit fly
BAA20774   185 Vst----------apRERVIDLVRSCkesILLTVI 209  human
XP_292955  347 Na------------tHEEVVHLLRNAgdeVTITVE 369  human
XP_294249  408 MrseaigdtrgwncsHDKVVSMLQGSgamPTLVVE 442  human

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