1O14


Conserved Protein Domain Family
FruK_PfkB_like

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cd01164: FruK_PfkB_like 
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1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.
Statistics
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PSSM-Id: 238570
Aligned: 73 rows
Threshold Bit Score: 220.867
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATPputative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:
  • Comment:annotation is transferred from other members of the superfamily
  • Citation:PMID 9519409

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1O14_A       13 MVLTVTLNPALDREIfiedfqvnrlyrindlskTQMSPGGKGINVSIALSKLGvPSVATGFVGGYmgKILVEELRKIskl 92  Thermotoga maritima
NP_738435     1 MILTVTASPYLLSTNdlsgpiei--ggvnamsqAATVAGGFGAGVANTLFLGGmETLSIFPAPEI--SHYLRLVKMSg-- 74  Corynebacterium ...
NP_824866     1 MILTVTPNPSLDRTYevpsldrg---eviratgERMDPGGKGVNVSRAVAAAGqRTVAVLPLGGApgAFVAALLDAQg-- 75  Streptomyces ave...
NP_825119     1 MILTVTLNTALDITYrvraltph---ashrvteMAERPGGKGLNVARVLAALGhEVTVTGFTGGAtgRALREQLAHTp-g 76  Streptomyces ave...
CAE49961      1 MILTFTPNPSIDKTLqldsvltr--gavqrlsgVQTVAGGKGINVAVALAKAQaDTVALYPAHPE--DPFNKLIRESq-- 74  Corynebacterium ...
ZP_00226191   2 NVLTVTPNPSIDHTVelatltrg---evhralsGTVEAGGKGVNVARALARHDhRATAVLPSGGVdgDRLEVLLAPQr-- 76  Kineococcus radi...
ZP_00293451   1 MILTVTPNPSVDRTLeidtyvrg---avirihnAMAHAGGKGVNVSRALRNHGvQTVAVLPVGGAegAQLTALLGEHg-- 75  Thermobifida fusca
YP_054859     1 MIVTVTLNPSIDRTApiagplrr--gqvnrlgsSTEVAAGKGVNISRVLRGAGiETCAVVPAGAK--GRLTLGLNHDd-- 74  Propionibacteriu...
YP_061708     1 MIVTLTANPSLDRAValagplrp--gevqfaasSREDAGGKGITVARVIAAAGvSTLAVLPLAGD--DPFGAVLRSSa-- 74  Leifsonia xyli s...
YP_062758     1 MILTVTPNPAIDLTYrvpaleag---ethrvapPTARAGGKGLNVARVIAQTGvAAFALTTAGGA--SGLRLAGDLE--- 72  Leifsonia xyli s...
Feature 1                                                                                       
1O14_A       93 ITTNFVYvegETRENIEIIDeknkTITAINFPGPDVTDMDVNHFLRRYKMTLs--kVDCVVISGSIPpgvnegICNELVR 170 Thermotoga maritima
NP_738435    75 LPYEIIPvagPIPMHLTMRDqe-gAETEFKNSPMPLDVSQLAMLRDLVVRKAe--dADWVLLGGELPsiapaaWFVDVVR 151 Corynebacterium ...
NP_824866    76 IDVAPVPvagATRSNISVAEpd-gTLTKINAPGPELTPAEAELLLETVREQYragdTTWITCCGSLPrglapsWYADLVA 154 Streptomyces ave...
NP_825119    77 VVDALVPvggATRRTIAVVDettgDTTQLNEPGPTVTPAEWAAFQEAYGELLr--sASAVALCGSLPpgvpvgAYAGLVR 154 Streptomyces ave...
CAE49961     75 IPAQRVTirgEVRINTTVTEpd-gTTTKLNIQGPQIHEDELQALQKNLLERTa--rCSWAVLAGSLPpgvptdWYVHLTK 151 Corynebacterium ...
ZP_00226191  77 VDAVTVAitgTIRTNTTVVEad-gTTTKLNEPGPRLSGPELDALLRVVTARLtv-rPDWLVASGSLPpgapsdLHARFVR 154 Kineococcus radi...
ZP_00293451  76 IAAVTVPvaaVTRCNITTAEtd-gTTTQLNVPGASLSEAEVAALLRAVESQLrh-hPKWLVAGGSLPqgtptdFYVRLSV 153 Thermobifida fusca
YP_054859    75 IPHQVVPvaaAVRTNLTITEpd-gTTTKINEPGADLSPEELTAVEEAIVEKSs--gAQWVVLSGSLPpgvpthWYATMTD 151 Propionibacteriu...
YP_061708    75 VPTRPVAihgHARANLTITDpa-gATTKLNLPGATLRAEEAETLGEAVVDACa--gASWLVLAGSLPpgvgddFYVTVIR 151 Leifsonia xyli s...
YP_062758    73 ASGIPSE---LVPVAAPTRA----TVAILAETGGALSAAEWNALRESANRLAg--pATALVGSGSLPpdapddIYAELVA 143 Leifsonia xyli s...
Feature 1                      #                     # #                                        
1O14_A      171 LARer----gvFVFVEQTPRLLERIyeg--pefPNVVKPDLRGNHasflg--------vdlktFDDYVKLAEKLAEKSq- 235 Thermotoga maritima
NP_738435   152 SLTlyh--pqvRVAISTTGAPLRAVirqlaasqPHLLVLTGEDLEiscgkepgelkaawsagdITTVVDVARGLIDRGis 229 Corynebacterium ...
NP_824866   155 RAHaa----gaRIALDTSGPALLEAlr----erPDVVKPNAEELAeavgr---------platVGDAVKAAEELRGLGag 217 Streptomyces ave...
NP_825119   155 AARaq----avPVLLDTSGEPLRRGva----arPDIVKPNAEELAel--------------tgSHEPWQATRDARRRGan 212 Streptomyces ave...
CAE49961    152 LLNarh--pslRIAIDTSDVPLQKVgesfgncaLSLIKPNGMELGqlvgldgyvlekeaaqgnFDPVVSAARKAILQGve 229 Corynebacterium ...
ZP_00226191 155 AARaa----gvRSAVDTSGPALAAAvd----agPDLVKPNQEELGellgr---------elltVGDVVAAARELRTRGvg 217 Kineococcus radi...
ZP_00293451 154 LARry----gvPIAVDTSGEPLAVTara---gaANLLKPNHHELAelldr---------elttLGDVVDATREVLSWGnd 217 Thermobifida fusca
YP_054859   152 RLHei----gvKVAVDTSDQPLQELaarlpdcaPDLVKPNSVELGqlcgidgdslesaatrgqFDDVVVAARGLHGIA-- 225 Propionibacteriu...
YP_061708   152 AVRerwgeaapRVAVDTAGEALRTVvad---arPDLIKPNDDELAelsgaa------ldpgdvERSVLRVARTLVPGRvg 222 Leifsonia xyli s...
YP_062758   144 IALah----riPSVIDADGRSLLAAae----agASVLKPNRRELAga--------------agTDDPVAGARLLLDAGag 201 Leifsonia xyli s...
Feature 1           #     #                         # #                                      
1O14_A      236 VSVVSYEVKNDIVATr-EGVWLIRSKEeidtsHLLGAGDAYVAGMVYYFIKhganflEMAKFGFASALAATRRKEKY 311 Thermotoga maritima
NP_738435   230 ELLITVNRGEAIHITg-DDVYVASFTGtp-gkQGVSWRESFVAGFLSAAKQers-peEQLSYAVAYANATGSEWDNF 303 Corynebacterium eff...
NP_824866   218 AVLASLGADGQLLVDa-SGTWFGSARVda-vrSDVGAGDSSLAGFLIAGGSg----aDALASAVAHGAAAVQLPGSV 288 Streptomyces avermi...
NP_825119   213 TVVASLGAEGLLAVNa-EGHWRATPPHrv-rgNPTGAGDSVVAGLLSGLVDqlp-wpRRLARAVALSAATVLSPVAG 286 Streptomyces avermi...
CAE49961    230 NVLVTLGAAGAVLVTk-DHAWKATPPPit-vlSTVGAGDASLAGFILASEDglp-peKCLAQAVAYGAAAASFAGTH 303 Corynebacterium dip...
ZP_00226191 218 EVLVSLGGGGALLVTg-DGVWWGGGEPlv-plSTVGAGDCTLAGYLHTGAPa----aQRLSTAMAWGRAAVLLPGSS 288 Kineococcus radioto...
ZP_00293451 218 AALVTLGSYGALLVEp-DRFWWAGGPPiv-prSTVGAGDSTLAGFLFDDGAp----eERLRRAVSWGSAAVALPGTT 288 Thermobifida fusca
YP_054859   226 EVIVTLGGTGALLITe-HDAWHARPEPve-vkSTVGAGDSSLAGFLLARTRgdq-peNCLRAAVAWGTAAAALPGST 299 Propionibacterium a...
YP_061708   223 AALITLGSRGSILVTp-SGGYVAAAPRir-vqSTVGAGDSALAGYLLADVAgas-apQRLAGAIRYGSAAAALPGTQ 296 Leifsonia xyli subs...
YP_062758   202 LVLVSLGGDGMLAVRpgAEPAGVRLPEpl-sgNATGAGDAAVAAVATALAAgeddplVLLRRAAAWSAAVLAPLAGE 277 Leifsonia xyli subs...

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