1A3Q,1NFI,1NFI


Conserved Protein Domain Family
IPT_NFkappaB

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cd01177: IPT_NFkappaB 
Click on image for an interactive view with Cn3D
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.
Statistics
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PSSM-Id: 238582
Aligned: 13 rows
Threshold Bit Score: 151.702
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              # #                                ##                   
1A3Q_A     186 LKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDde----nGWQAFGDFSPTDVHKQYAIVFRTPPYHKMk----- 256  human
1NFI_A     175 LKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGP-------GWEARGSFSQADVHRQVAIVFRTPPYADPs----- 242  human
1NFI_B       3 LKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEeen--ggVWEGFGDFSPTDVHRQFAIVFKTPKYKDIn----- 75   human
BAA96798   201 LYIHRICNAKGSINGGTEVNLLIKLPSKLCPQISIKKIhpetmetEWERFVNVKQSDIFGNHAITFITPRYDNPqannea 280  Sarcophaga pereg...
AAM97894   242 LKICRLSATVGNVDGGEEVFMFVEKVCKNNIKIRFYELdey-dqeIWQDWGSFSEADVHHQYAIAFKTPAYHNKd----- 315  yellow fever mos...
CAA65156   227 LIICRLSDCTAPVSGGKEIILLCEKVVKEDIKVRFFEKkgn--atVWENYAEFSHTDVHKQVAISFRTPPYRTId----- 299  African malaria ...
P15330     225 LVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEkng--qsVWEAFGDFQHTDVHKQTAITFKTPRYHTLd----- 297  fruit fly
T14892     258 LKICRMDKSAGCCTGGEEVYLLCDKVQKEDIQVKFFEIsad-gqmVWQSLAEFGPTDVHRQYAIVFKTPAYKDIn----- 331  purple urchin
NP_477094  343 LRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEded-getVWEAYAKFRESDVHHQYAIVCQTPPYKDKd----- 416  fruit fly
P51510     256 LKISRMNKEYGRCEGGEEVYILCDKVQKEDILVIFGED-------KWEARADFSQADVHRQIAIVLKTPPYHDLh----- 323  African clawed frog
P01126     194 LRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLG-------NWEAKGSFSQADVHRQVAIVFRTPPFLGDi----- 261  Reticuloendothel...
AAK72690   259 LVICRVDRHSGKAKGGDEVFLLCEKINRDDIVVRFYEEtdc-gecVWEDFADFSTNDIHRQYAIVFRTPPYKDTm----- 332  Pacific oyster
BAB47173   191 LRICRVDKSFGSCKGGDEVYLLCDKVQKDDISVCFFDLn-----tGWESYGEFSPTDVHRQVAIVFRTPPYENTh----- 260  Halocynthia roretzi
Feature 1                                     
1A3Q_A     257 -iERPVTVFLQLKRKRGGDVS-DSKQFTYYP 285  human
1NFI_A     243 -lQAPVRVSMQLRRPSDRELS-EPMEFQYLP 271  human
1NFI_B      76 -iTKPASVFVQLRRKSDLETS-EPKPFLYYP 104  human
BAA96798   281 nnGHDIKVKISVVIRNSTYRS-NSVDFYYVR 310  Sarcophaga peregrina
AAM97894   316 -iTEPVEVLMQLYRPRDKCQN-EPVPFKFKP 344  yellow fever mosquito
CAA65156   300 -iSDPVRVFVQLERPSDNTYS-EARDFQFIP 328  African malaria mosquito
P15330     298 -iTEPAKVFIQLRRPSDGVTS-EALPFEYVP 326  fruit fly
T14892     332 -iDKPVYVHVQLKRKSDNETS-DPKPFTFHP 360  purple urchin
NP_477094  417 -vDREVNVYIELIRPSDDERSfPALPFRYKP 446  fruit fly
P51510     324 -iTEPACVRVFLQRITDGIRS-EGMPFVYMP 352  African clawed frog
P01126     262 --TEPITVKMQLRRPSDQAVS-EPVDFRYLP 289  Reticuloendotheliosis virus
AAK72690   333 -iTRPKEVKMQLKRNNEPETS-DSIPFIYMP 361  Pacific oyster
BAB47173   261 -iREATKVMFQLKRSSDGETS-DSKDFTYLP 289  Halocynthia roretzi

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