1K6W,1K70


Conserved Protein Domain Family
Bact_CD

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cd01293: Bact_CD 
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Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi, but not mammalian cells. The bacterial enzymes, but not the fungal enzymes, are related to the adenosine deaminases (ADA). The bacterial enzymes are iron dependent and hexameric.
Statistics
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PSSM-Id: 238618
Aligned: 38 rows
Threshold Bit Score: 303.785
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                   # # 
1K6W_A        7 TIINARLpge---------------egLWQIHLQDGKISAIdaqsgv------mpitenSLDAEq-GLVIPPFVEPHIHL 64  Escherichia coli
ZP_00031429   8 ALRNVRVpacttaqp-----ahsgdfvEADLLIEDGRIAAVapagt--------vpaadGPDLGr-SLVLPGMIDCHTHL 73  Burkholderia fun...
NP_440847    23 NLVKTKVnfpenfqf----prpwedlgLYHLEIADGKIKNIvavgqgeesdlvtddgvpRVDLSk-RMILPCFVDMHTHL 97  Synechocystis sp...
AAB17512     31 LLANDVPgaaevd---------rdgsaLVDILVENGKIAAItpala--------dggedAVALDg-RHVWPLLIDAHAHL 92  Rhizobium legumi...
NP_893421    20 NVDNLNVdde--------------gfaSVFVAWEKGIISELkp--------------inIKNKKpkKILFPRFVETHSHL 71  Prochlorococcus ...
NP_875769    28 GLLQAQItee--------------glcPLRMHIKDGCLNEIevi-------------qhSKESSl-SLLLPRLIEPHAHI 79  Prochlorococcus ...
NP_894159    23 DVLSARVtae--------------glcPLRICWQDGRLCSFeli-------------daDVLSPk-RLLLPRLAEPHAHL 74  Prochlorococcus ...
ZP_00072513  42 WLKNAHVpacliereleisdqtrvglsLVDIEIKEGVITQIvhsladlp--slnngdipRVDLKg-GMVWPCFVDMHTHL 118 Trichodesmium er...
1K70_A        7 TIINARLpge---------------egLWQIHLQDGKISAIdaqsgv------mpitenSLDAEq-GLVIPPFVEPHIHL 64  Escherichia coli
AAK50324     18 ELHNARLprwllrhdw---pnlqgapaLARVVLRAGVVDSIepmppen-----tpmpadAWDLRg-APVLPAFVDAHVHL 88  Pseudomonas sp. ADP
Feature 1                                                                                       
1K6W_A       65 DTTQtagqpnwnqsgtlfegierwaerkallTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDa-tLTALKAMLEVKQev 143 Escherichia coli
ZP_00031429  74 DKGHiwprqpnptgdvpgaahatgvdrtarwNAEDVRRRMEFGLMTAWAHGVVAIRTHLDCLApqaAISLPVLEALRDaw 153 Burkholderia fun...
NP_440847    98 DKGHiwgrspnvdgtfsgaiasterdaelhhSPEDIYRRMEFALQCSYAHGTAAVRTHIEMAGqksQIAWQTFQQLRQaw 177 Synechocystis sp...
AAB17512     93 DKGHtmgrapdsggthpgaraattadrlahwNADDLLRRMEFGLATADAHGVAAIRTHLDSHEgqaEITWSAFAEMRErw 172 Rhizobium legumi...
NP_893421    72 DKSFtfgefpnfksnyh-ealsvnleehktrSKIKVLERAEKSLNLALKNGYRAIRSHVDTYEsqdNNIWDELFKIQKky 150 Prochlorococcus ...
NP_875769    80 DKAFtwksfpnfsgtyq-nalqanleeqkgrTMQKVRDRAERSMKLSLKNGIRAVRSHVDSFDssgQQTWEVLKNIKSew 158 Prochlorococcus ...
NP_894159    75 DKAFtwldfpnlhgtyg-gamvanfkerqsrTLIGVRQRAERSLKLALRHGLRAMRSHVDSLGpatDSSWEALLDLQRqw 153 Prochlorococcus ...
ZP_00072513 119 DKGHiwerspnpdgsfngaldagardgekywNAEDIYRRMEFGLKCSYAHGTKAIRTHLDCFAqqaNISLEVFQTLQKkw 198 Trichodesmium er...
1K70_A       65 DTTQtagqpnwnqsgtlfegierwaerkallTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDa-tLTALKAMLEVKQev 143 Escherichia coli
AAK50324     89 DKTFtlqrvgpippgll-aaidaeqrdallwTADDVAGRAAQGLCWGHAAGTRYMRSHVNWQVhepPLAWSVLNELAArw 167 Pseudomonas sp. ADP
Feature 1                                                                                    #  
1K6W_A      144 apwiDLQIVAFPQEGilsy-pngEALLEEALRLGa-dVVGAIPHfe-----ftREYGVESLHKTFALAQKydrLIDVHCD 216 Escherichia coli
ZP_00031429 154 agriALQANVLVPLDvyl--tdeARALADAAQRAg-aTLGAVARfrtlpnhpiTPQFDVAMTRLLRLASErglDVDLHVD 230 Burkholderia fun...
NP_440847   178 adrlTLQGVAMVTTDyyl--gsaGEKLADQMAHGg-gILGGVAYa--------GPQVEAQLTRLMTLAQArnlAIDLHVD 246 Synechocystis sp...
AAB17512    173 kgriTLQAAGLVPLDayrg-dygARLADIVAAHGg--LLGGVTRasggthgagLDDIDLLLDRLFALAKErglDVDLHVD 249 Rhizobium legumi...
NP_893421   151 ssklKLQYVALAPLEfwdt-phgEELAKIFSKKKg--ILGGVLVppf----knRAKIKYLLSKTLLLADKyklEIDLHID 223 Prochlorococcus ...
NP_875769   159 eefvELQLVALVPLEywtt-krgKDLARQVSAEGg-lLGGVIVPpy------hKANLRELLINFFCLANDmgcGIDIHVD 230 Prochlorococcus ...
NP_894159   154 qewmELQWVALVPIEhwst-regDQLAGRVAEVGg-lLGGVVVPpf------dPGKTRDSLRQMLQLADRlgcGIDLHID 225 Prochlorococcus ...
ZP_00072513 199 esrlILQPVSLVTGDyylt-eagEKLADQIADIGg--ILGGVPFi--------NSDLDNQLDRLFSIAKErqlDLDLHTD 267 Trichodesmium er...
1K70_A      144 apwiDLQIVAFPQEGilsy-pngEALLEEALRLGa-dVVGAIPHfe-----ftREYGVESLHKTFALAQKydrLIDVHCD 216 Escherichia coli
AAK50324    168 adrvTLDLVAFPSLSlfssledaRRIAQHVARSGphaRLGGFVHs--------VSWSREALRNLLMVAQEfglDVDLHVD 239 Pseudomonas sp. ADP
Feature 1       #                            #                                                  
1K6W_A      217 EiddeqsrfVETVAALAHHEGmgaRVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPlvnihlqgr-fdtypkrrgI 295 Escherichia coli
ZP_00031429 231 EstdptsrmLPEVARIVRRERfdgRVLCGHCCSLALQDERYVDATLDALAAARIDIVSLPtvnlylqsrapgktptwrgV 310 Burkholderia fun...
NP_440847   247 EngdrrsrvLHQVAAIALKVGftgQIVCGHCCSLDVQSPQQVQQTLALVKQANIAIISLPlcnlylqgrhqpqkpawrgI 326 Synechocystis sp...
AAB17512    250 Eaaq--adsLPHVARAAIRHGyegRVTCGHCCSLALLGEQELRDTIALIADAGLSIITLPtvnmylqdredgrtprwrgV 327 Rhizobium legumi...
NP_893421   224 EstiepgagIKVLLETIDRLNikvPITCSHLSSILSLNNNEILNLGSKIAEKDIKVIALPltnfwllnrkekstslnrpV 303 Prochlorococcus ...
NP_875769   231 EtsltpgggIREIIYVLEQIDldiPITCSHLSSMGLLPSNPLKLLAERIASFNINVVALPftnfwllarsdktspirrpI 310 Prochlorococcus ...
NP_894159   226 EsqshpaagLKQLLLVLDRMSitvPITCSHASSMGLLPPGAVSRLADRMAHHRLNVVSLPltngwllskqprrtpverpL 305 Prochlorococcus ...
ZP_00072513 268 EngdpnsrvLHKVAEKAISHQfygKIICGHCCSLAVQTPEKVTETIKLVKEAGISIVSLPmcnlylqnrqenytprwrgV 347 Trichodesmium er...
1K70_A      217 EiddeqsrfVETVAALAHHEGmgaRVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPlvnihlqgr-fdtypkrrgI 295 Escherichia coli
AAK50324    240 EelnpdavgLLAVAEIVKEINfagRVVCGHVCALAAKPPAQALATLDAVAELPITLVCLPttnlllqdaavgrtplmrgI 319 Pseudomonas sp. ADP
Feature 1                        #                                                              
1K6W_A      296 TRVKEMLESGInVCFGHDDVFDPWYPLGTANMLQVLHMGLHVCQLmGYGQINDGLNLITHHSARTlnl-qdyGIAAGNSA 374 Escherichia coli
ZP_00031429 311 TLLHEMRARGLrVAVAGDNCRDPFYAYGDHDMLDTFTQAVRILQLdHPIGDWLAAATRTPAQIMGleagprgVVAAGEPA 390 Burkholderia fun...
NP_440847   327 TKVHAIHAEGIpLVFASDNCRDPFFPFGDHDGLEILNQSVRIGQLdPPYGHWCATVNQTPAQLMGlad--ygRLAVNGPA 404 Synechocystis sp...
AAB17512    328 TPVQELQAAGIpVAAAGDNCRDPFFAYGDHDMLDTWRQAVRILHLdHPYADAPALAGPAPAGVMGid---vgTIGAGRPA 404 Rhizobium legumi...
NP_893421   304 APIKQLQKSLVdVSIGSDNVQDPWYPFGNYDPFYLMSLAMPMLQLnPWERLTLSSIFLSPSRLLNltw--dgVVKKGCPV 381 Prochlorococcus ...
NP_875769   311 APIKQLQNAGVnVAIGGDNVQDPWYPGGNFDPLSLMAASMAFAQI-APWNRLGLSTFTTGAARIMqle-wdgIIDIGCPA 388 Prochlorococcus ...
NP_894159   306 APIHQLQLAGVtVAVGGDNVQDPWFPVGNFDPLALMAFSLPLAHLaPWQRLGLAPFTTAAARVMSlsw--egTLQPGSPA 383 Prochlorococcus ...
ZP_00072513 348 TLLHELKKQGIsVAIASDNCRDPFFGFGDHDVLEVFNMSVRIAHLdMPYGDWPCAVTKTPGDLIGlpn--vgIIKVGLPA 425 Trichodesmium er...
1K70_A      296 TRVKEMLESGInVCFGHDDVFDPWYPLGTANMLQVLHMGLHVCQLmGYGQINDGLNLITHHSARTlnl-qdyGIAAGNSA 374 Escherichia coli
AAK50324    320 TLIKEARARAIpVLFGSDNVQDPFCRVGSYDPVDSFMAAVLAAQLdEPFDDWSQSICRGDWLQKQas---npGNKFAWPA 396 Pseudomonas sp. ADP
Feature 1                                     
1K6W_A      375 NLIILPAENGFDALRrqVPVRYSVRGGKVI 404 Escherichia coli
ZP_00031429 391 DVIVTRARDYSELLSrhQFDRVVLRAGRPI 420 Burkholderia fungorum
NP_440847   405 DLVIFPARYFSEIFSrpQGDRLVIRKGKPT 434 Synechocystis sp. PCC 6803
AAB17512    405 DLMILEAWSLDQVIArpHSDRVLLRKGIFA 434 Rhizobium leguminosarum bv. trifolii
NP_893421   382 NFVLLDAGNWADIFSt-NLKREVLINGELY 410 Prochlorococcus marinus subsp. pastoris str. CCMP1986
NP_875769   389 DFVLLDADSWAGAMSt-PPIRKVMINGHWI 417 Prochlorococcus marinus subsp. marinus str. CCMP1375
NP_894159   384 NLLLLEAGSWAEALAv-PPRREVIVDGNCL 412 Prochlorococcus marinus str. MIT 9313
ZP_00072513 426 DLILFKGRNFSELLSrsQHDRVVLRNGLVI 455 Trichodesmium erythraeum IMS101
1K70_A      375 NLIILPAENGFDALRrqVPVRYSVRGGKVI 404 Escherichia coli
AAK50324    397 DLVIFTGADAQSWPAr-AHERVLLRQGRLL 425 Pseudomonas sp. ADP

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