1GKR


Conserved Protein Domain Family
L-HYD_ALN

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cd01315: L-HYD_ALN 
Click on image for an interactive view with Cn3D
L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in biotechnology). But L-HYDs differ by having an L-enantio specificity and by lacking activity on possible natural substrates such as dihydropyrimidines. Allantoinase catalyzes the hydrolytic cleavage of the five-member ring of allantoin (5-ureidohydantoin) to form allantoic acid.
Statistics
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PSSM-Id: 238640
Aligned: 14 rows
Threshold Bit Score: 628.935
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1GKR; Arthrobacter aurescens L-Hydantoinase (Dihydropyrimidinase)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                            # #        
1GKR_A        3 DVIVKNCRLVSs----dGITEADILVKd-GKVAAISadts-------dveaSRTIDAGGKFVMPGVVDEHVHIIDMdlk- 69  Arthrobacter aur...
O32137        4 DMVIKGAKAVTp----dGVIEADIVVQn-GVIAEIGsdie--------asgTEIIQADGKYVFPGVIDCHVHFNEPgr-- 68  Bacillus subtilis
NP_816614     4 ELVIKNGLVILe----tGEVITDVAVQg-GKIVAIGqdl----------sgERVIDATGLVVSPGMVDAHVHITDPgggy 68  Enterococcus fae...
ZP_00098992   5 DLILRNGNVVCp----dGVRKADIAVSd-GKIVLIAeeip--------gdaKEIIDAAGKHIFPGITDGHVHFNDPgr-- 69  Desulfitobacteri...
Q9RV76        4 DLLLRGAVLVTp----eGERRADLGIVg-GQIAELTdeia--------tpaAQTLDVSGLHVFPGVLDDHVHLNEPgr-- 68  Deinococcus radi...
NP_573287     2 DLLFLSRRIFLgdgsqnALIHGGIIVDteGIIRRVLrspqevntylyntesESVYDFGDLVLMPGLIDPNVHINEPgr-- 79  fruit fly
ZP_00098991  18 NLVIKNGKVVTa----dKIIEASLGINn-GKIAAIIeagt-------eiqaEKVIDAKGNYVFPGAIDTHAHLNDPgy-- 83  Desulfitobacteri...
AAM63760     44 HYWISSKRIVTp----nGLISGSVEVKg-GIIVSVVkevdwh---ksqrsrVKVIDYGEAVLMPGLIDVHVHLDDPgr-- 113 thale cress
AAN72834     31 MKIFRSRRVLLgd---gTERDAGIVVDssGRIKSIIsgeever--ianetkVEVLDYGQFSIWPGVIDSHVHVNEPgr-- 103 cat flea
Q9RKU5        5 ELVLRSTRVITp----eGTRAASVAVTg-EKITAVLpydap------vpagARLEDVGDHVVLPGLVDTHVHVNDPgr-- 71  Streptomyces coe...
Feature 1                                                                                       
1GKR_A       70 -nrYGRFELDSESAAVGGITTIIEMPItfpPTTTLDAFLEKKKQAGQr-LKVDFALYGGGVPg---nLPEIRKMHDAGAV 144 Arthrobacter aur...
O32137       69 -edWEGFETGSQMMAAGGCTTYFDMPLnciPSTVTAEHLLAKAELGRqkSAVDFALWGGLVPg---hIEDIRPMAEAGAI 144 Bacillus subtilis
NP_816614    69 rdeWEGYVTGTAACAKGGVTTFMEMPLnqiPATVDKTSLEIKYKAGEnkLKVDVGSFGGVVPtn--lADGIQELDEGGVS 146 Enterococcus fae...
ZP_00098992  70 -teWETITTGSSALAAGGGVAYFDMPLncsPCTLDAVNFNNKLAVAQkdSLVDYGFWGGLTSa---nLDKLDELAECGVI 145 Desulfitobacteri...
Q9RV76       69 -thWEGFETGTQALAAGGATSFLDMPLnssPPVLTRERFEDKARLGEekSLIDFGLWGGLTPl---nLDQLDDLAECGVI 144 Deinococcus radi...
NP_573287    80 -kdWEGFATATKAAAAGGFTTIIDRPTnaqPPTVSVAHLKAKTSTARgkIYVDVGFWGGLVPg---nGDQLAALLGAGVM 155 fruit fly
ZP_00098991  84 -lwREDYAHGTAAAGVGGFTTIIDMPLqnePAMTDGQILDKKLEVVSpnAYVDFCFWGGLVDy---nLNQLKELDEKGCV 159 Desulfitobacteri...
AAM63760    114 -seWEGFPSGTKAAAAGGITTLVDMPLnsfPSTVSPETLKLKIEAAKnrIHVDVGFWGGLVPdnalnSSALESLLDAGVL 192 thale cress
AAN72834    104 -esWEGYTTATKAAAWGGITTIVDMPLnsiPPTTTVENLRTKVNSACgkTHVDVAFWGGVIPg---nAHELLPLINAGVR 179 cat flea
Q9RKU5       72 -teWEGFWTATRAAAAGGITTLVDMPLnsiPPTTTVDNLRTKREVAAdkAHIDVGFWGGALPd---nVKDLRPLHEAGVF 147 Streptomyces coe...
Feature 1                                                     #                                 
1GKR_A      145 GFXSMMAASvp----gMFDAVSDGELFEIFQEIAac----gsVIVVHAENETIIqalqkqikaaggkdmaayeaSQPVFQ 216 Arthrobacter aur...
O32137      145 GFKAFLSKSgt----dEFRSVDERTLLKGMAEIAaa----gkILALHAESDAITsylqmvlankgkvdadayaaSRPEEA 216 Bacillus subtilis
NP_816614   147 GYKCFLGTCgdrsiegDFQNVDDYSLYEGMKQVAkt----gkVLAIHAENAPITdklgavayqngettlaayvaTRPVFT 222 Enterococcus fae...
ZP_00098992 146 GFKAFACHSgi----dEFPRMDDYTALVGMEKLAkl----glPLMVHCENAEITkeltelslannrtgvrdyfaARPPIT 217 Desulfitobacteri...
Q9RV76      145 GLKAFMSHSgl----dEFPAADDLTLYEGMRTAKrh----glVVATHAESNEFTrrltetaraqgksgvrdyleSRPVVT 216 Deinococcus radi...
NP_573287   156 GLQCTLCDPaap-vsqEFPAVNESQLEEALSQLDkdqaegeaIVAVHAELPLTTeihpdeeap---reygtflvTRPPQM 231 fruit fly
ZP_00098991 160 AFKSFIGPVs-----pDYVSLTIGQAKEAMEICKef----dgRAGFHCEDYSLIkweearakrkdtndwqdfldSRPVIA 230 Desulfitobacteri...
AAM63760    193 GLKSFMCPSgi----nDFPMTNITHIKEGLSVLAky----krPLLVHAEIERDLeiedgsend--prsyltylkTRPTSW 262 thale cress
AAN72834    180 GFKCFTSESgv----dEFPQVTKNDLEMALKELQka----nsVLLYHAELPAPQenvtsnet----ekymtylkTRPPSM 247 cat flea
Q9RKU5      148 GFKAFLSPSgv----dEFPHLDQEQLARSLAEIAaf----dgLLIVHAEDPHHLaaapqqgg----pkythflaSRPRDA 215 Streptomyces coe...
Feature 1                                    #                                                  
1GKR_A      217 ENEAIQRALLLQKEag-------crLIVLHVSn-pDGVELIHQAQseGQDVHCESGPQYLNITTDDAERIGPYMKVAPPV 288 Arthrobacter aur...
O32137      217 EVEAVYRTIQYAKVtg-------cpVHFVHISt-aKAVRLIREAKqeGLDVSVETCPHYVLFSHDDLRQRGSVAKCAPPL 288 Bacillus subtilis
NP_816614   223 EVEAIQKAILFAKEtg-------crIHICHVAc-qEGVEEVLKAQaeGVDVTCETCTHYLYFTTDELDAIGPVVKCSPPI 294 Enterococcus fae...
ZP_00098992 218 EIENVSRMITFAEEtg-------ckLIIAHISt-aKAVELVAQARarGVDVYCETIGHYLYLTGDDVERLGTVAKCSPPI 289 Desulfitobacteri...
Q9RV76      217 ELEAVQRALLFAQDtg-------aaLHLVHVSs-gAAVALAYEGKqkGIDVTIETCPHYLHFTGEDVERVGAALKCAPPL 288 Deinococcus radi...
NP_573287   232 EISATQLLCRLANRhpr------rcIHILNCSs-gESLPLVEECRrqGGNLTVDTCPHYLALAAEDVPDCGTEFKTWPPI 304 fruit fly
ZP_00098991 231 ELIATQNIIDLAKEvg-------akVHICHVSh-pRVAEIIRQAQneGVDVTAETCGHYLTFTDQDVVKNGSLFKCAPPL 302 Desulfitobacteri...
AAM63760    263 EEGAIRNLLSVTENtriggsaegahLHIVHLSdasSSLDLIKEAKgkGDSVTVETCPHYLAFSAEEIPEGDTRFKCSPPI 342 thale cress
AAN72834    248 EVNAIDMIIDLTKKyk-------vrSHIVHLSa-aGALPQLKKARseNVPLSIETCHHYLTFAAEDVPDGHTEYKCAPPI 319 cat flea
Q9RKU5      216 EDTAIATLLAQAKRfn-------arVHVLHLSs-sDALPLIAEARadGVRVTVETCPHYLTLTAEEVPDGASEFKCCPPI 287 Streptomyces coe...
Feature 1                               #                                                       
1GKR_A      289 RSAEMNIRLWEQLENGl-IDTLGSDHGGHpvedkep----gwkdvwkAGNGALGLETSLPMMLTNGVNkgrl---slerL 360 Arthrobacter aur...
O32137      289 RSRQSKETLIETLIAGd-IDMVSSDHSPCrpslkr------ednmflSWGGISGGQFTLLGMLELALEhqip----fetI 357 Bacillus subtilis
NP_816614   295 RDADQQAALWNHVQTGg-IAFVTSDHSPCtpdlkd------ttnafeAWGGISGVQNNVDVLFDEAVQkrgl---slkqF 364 Enterococcus fae...
ZP_00098992 290 RDGENQLQMWGRLFNDn-IAFVSSDHSPCdpklkn-------gefmrVWGGISACQTTLQGLLTHAYHdrkf---plvkI 358 Desulfitobacteri...
Q9RV76      289 RDPAVQEELWRELLAGh-IDTVGSDHSPAppdmkt------sedffsLWGGISGAQSTLNVMLEDGYAqrgl---pleiI 358 Deinococcus radi...
NP_573287   305 RERRNQEQLWQALRPGgaIRMIGSDHSPAtpgaraltcgrgrgnflkAWPGINSLQLSLSVVWTAAANrrgsanltiadI 384 fruit fly
ZP_00098991 303 RDAAAVERMWEYVNNGt-LSAIASDHSPCelsekse----ekhgvfgAWGGISGIQNVMQVVFSEGVVkrgy---cptlL 374 Desulfitobacteri...
AAM63760    343 RDAANREKLWEALMEGd-IDMLSSDHSPTkpelklm----sdgnflkAWGGISSLQFVLPITWSYGKKygvt----leqV 413 thale cress
AAN72834    320 REESNQEKLWQALENRd-IDMVVSDHSPSpaalkglcn-gchpdflkAWGGIAGMQFGLSLIRTGASKrgfk----ahdV 393 cat flea
Q9RKU5      288 REAANQDLLWQALADGt-IDCVVTDHSPStadlkt-------ddfatAWGGIAGLQLSLPAMWTAARGrglg----ledV 355 Streptomyces coe...
Feature 1                                                                                       
1GKR_A      361 VEVMCEKPAKLFGIypQKGTLQVGSDADLLILDLDIDTKVDASQfr--slHKYSPFDGMPVTGAPVLTMVRGTVVAEkgE 438 Arthrobacter aur...
O32137      358 AEWTAAAPAKRFGLq-KKGRLEAGCDADFVLVSMEPYTVTRESMfa---kHKKSIYEGHTFPCSISATYSKGRCVYNdgE 433 Bacillus subtilis
NP_816614   365 ADMIAANPADRYHLa-QKGRISIGKDADFVLIKPNAPYILKAEDle--yrNKISPYIGREIGAQVIQTILRGETIYAqeT 441 Enterococcus fae...
ZP_00098992 359 AQLTAQHVNEIFKIk-DKGQIALGYDADFALVDLDHEFTLQAEDlf--ykHKVSPYVGDRFRGSVSQTILRGTTIYKdgK 435 Desulfitobacteri...
Q9RV76      359 AALLALNPAQRFGLp-QKGRLAVGADADFALVALGEKFTLDTLYd----rWQQNPYRGQSFQGRVHATYLRGQPVYQngE 433 Deinococcus radi...
NP_573287   385 HRLMCQEPANLCGLsaSKGRIAEGYDADFCVWSPEEEFTVGPELly--taTKATPYAGQKLRGVVHATVVRGLHVYQqfE 462 fruit fly
ZP_00098991 375 ARSLSEGPAKAFGIfgKKGAIQVGFDADLVILDPEKEWEITPESly--yvNPISAFVGLKGKGLPVCTLVRGEVVAQdgQ 452 Desulfitobacteri...
AAM63760    414 TSWWSDRPSKLARLh-SKGAVTVGKHADLVVWEPEAEFDVDEDHpihfkhPSISAYLGRRLSGKVVSTFVRGNLVFGegK 492 thale cress
AAN72834    394 SRLLSAGPAKLTGLdgIKGQIKEGLDADLVIWDPEEEFKVTKDIiq--hkNKETPYLGMTLKGKVHATVVRGDFVYRngQ 471 cat flea
Q9RKU5      356 VRWMSERTAALVGLdaRKGAIAPGHDADFAVLAPDETFTVDPAAlq--hrNRVTAYAGKTLYGVVKSTWLRGERIVAd-G 432 Streptomyces coe...
Feature 1                   
1GKR_A      439 VLVEqgfGQFVT 450 Arthrobacter aurescens
O32137      434 KVTEi-dGALVV 444 Bacillus subtilis
NP_816614   442 GVTEafnGVFIK 453 Enterococcus faecalis V583
ZP_00098992 436 IVSQp-iGKHLR 446 Desulfitobacterium hafniense
Q9RV76      434 FTGTp-rGRLLR 444 Deinococcus radiodurans
NP_573287   463 GFGQp-lGKVLL 473 fruit fly
ZP_00098991 453 LVGQkghGEYVR 464 Desulfitobacterium hafniense
AAM63760    493 HASDa-cGSLQL 503 thale cress
AAN72834    472 PFEIp-kGNLLI 482 cat flea
Q9RKU5      433 AFTDp-kGQLLD 443 Streptomyces coelicolor

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