Conserved Protein Domain Family
DHOase_IIa

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cd01317: DHOase_IIa 
Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C.elegans protein involved in axon growth.
Statistics
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PSSM-Id: 238642
Aligned: 31 rows
Threshold Bit Score: 297.611
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 # #                                   
O66990       42 EAEIIDa-----------------------kGLIVCPGFIDIHVHLRDPGqtykEDIESGSRCAVAGGFTTIVCMPNTNP 98  Aquifex aeolicus
ZP_00033184  42 ADKTIDa-----------------------qGLHVMPGLVDLSARLREPGyehkATLESEMTAALAGGVTSLVCPPDTDP 98  Burkholderia fun...
NP_926768    43 ADRAIDga----------------------gRLILAPTLCDLYVRSGEPGheerEDLASLAAAAAAGGYSQVAILPHTEP 100 Gloeobacter viol...
P72934       44 DAAVIPg-----------------------eNLLLAPSLADLYSYSGEPGyedrETLSQLVKTAIAGGFGDVAILPNTDP 100 Synechocystis sp...
NP_682323    42 AAEVIDa-----------------------sDWVLAPPLVDLYSHSGQPGyearETLDSLLAAAAAGGVQYLNLLPTTEP 98  Thermosynechococ...
CAD01099      8 TAQIVDllptafsqslpssvseqltnnasdhQMWLLPPLVDLCARLREPGlqqhGTLASEGSAALANGFLHVVIPPDTNP 87  Psychrobacter sp...
NP_907634    20 GEEVVLa-----------------------eGLSLLPAMVDLNVRVANDSlt-gKNLATLAKKAAKGGVGSLALMPDCSP 75  Wolinella succin...
NP_861297    37 DEDIYDa-----------------------kDRILFPAMIDLNVAPKSLSls-rKNLLSLAQKALKGGAGSILLYPHTTP 92  Helicobacter hep...
NP_874907    44 YELKIDkts--------------------aeKLFFAPCLVDPHSVLEDYLngkaETLWTLMKKAANAGYGQIALLPKASP 103 Prochlorococcus ...
NP_282342    32 GEEILDa-----------------------kGMTLLPSFVDLCVSLKNDKfs-lANLELLENECLKGGISSIVLRDCMDF 87  Campylobacter je...
Feature 1                                                                                       
O66990       99 PIDnTTVVNYIl-QKSKSVGLCrv--------------------lpTGTITkg-rKGKeIADFYSLKEAgCVAFTDDgsp 156 Aquifex aeolicus
ZP_00033184  99 TLDePGLVEMLk-FRARNLNQAhv--------------------ypLGALTvg-lKGQvITEMVELTEAgCIGFSQAdvp 156 Burkholderia fun...
NP_926768   101 PVDdPAQVDFL--RRHFPAGPVea--------------------lvLGAISrn-cAGEaLAEVSSLLEAgVVGFTDArpl 157 Gloeobacter viol...
P72934      101 PLDqPQTLQWLkqRLNQIEGVNahhqppgdpqaenrpdsapvqchwWGSVTqg-nQGKqLTEWGELDQAgVIGFSDGgai 179 Synechocystis sp...
NP_682323    99 VIDdPAPWQALq-RQIPPTAWSqv--------------------rvWGALTqg-cKGAaLTNLAELAASgVVGFCDDrgl 156 Thermosynechococ...
CAD01099     88 ILEnGSLLKGLr-ERALEDGGIhl--------------------hiLGALTag-lKGErPSNIAGLKKGgCIAVSNArrp 145 Psychrobacter sp...
NP_907634    76 SLDnEAAIELL--NSYKGELPAsi--------------------fpIASATkk-eDGK-LSDLSILHKMgCRGIAIEss- 130 Wolinella succin...
NP_861297    93 SCSeNGSIELIk-SLNKESPIHl-----------------------IPAISpldsQGK-LSDISTLHTNgAKAIFAPsd- 146 Helicobacter hep...
NP_874907   104 WRDkPEYLYSIk-NLGQDVLIHl-----------------------WGGFSqk-gAGEkLTSHKDLIDHgAVGLADDdwm 158 Prochlorococcus ...
NP_282342    88 DEE-SFALFLQ--NLAQRKMQI------------------------FSSVRvkdaNGK-LKNLATLLNKgACALELDss- 138 Campylobacter je...
Feature 1                              #                                                     #  
O66990      157 vmdSSVMRKALELASqlgvPIMDHCEDDKLa-yGVINEGEVSALLGLSSRAPeaeeiqIARDGILAQrtg-ghVHIQHVS 234 Aquifex aeolicus
ZP_00033184 157 vvdTQVLLRALQYAKtygyTVWLRPVDAYLgkgGVAASGALASRLGLSGVPVsaetiaLHTIFELVRvtg-arVHLSHVS 235 Burkholderia fun...
NP_926768   158 -anWALLRRFLDYAAvlerPVLVWPCFAPLa-tGIALEGDWAIRLGLAGRPPqaegiaLAGVLELVRltg-taVHLMRLS 234 Gloeobacter viol...
P72934      180 -qdWRLLQRALEYGAiagkPLALVPLNLSLrgnGVMREGPLAIQLGLPPDPVmseaavIASLLELLPhyg-tpVHFMRIS 257 Synechocystis sp...
NP_682323   157 -thWPLLQRALTYVQplekPVALWPFDSALaasGVARQSGVATRLGLVEQPVccetipLLAILELARtvs-tpIHLMRLS 234 Thermosynechococ...
CAD01099    146 fenDLVQLRTLEYAAtfgmKVFFYPDEPSLsgdGVAHEGYIASYHGLQGIPWiaetvaLSTQLLMVEetg-iaAHFSQLS 224 Psychrobacter sp...
NP_907634   131 -ldGNLSRRVCEYSLmmkaPIFCRCEDVSLrgsGVMNDGYLSSRMGLPGIPSlsetkeVAKMAETAIfmr-tpVLFQALA 208 Wolinella succin...
NP_861297   147 -idAHSLMSIAQYAQmldiPLMCFCQDSSVa-dGVMNEGILSASLGLPSIPAysqtkeVAKIAEMFKnmp-ikLIFDTLV 223 Helicobacter hep...
NP_874907   159 -ipIELLKKGLILNEtkekPILLAPRDLAIqghGLVRESVEALRAGWHQDPVasetipLGTLLELQKqhpsskIRLMNLS 237 Prochlorococcus ...
NP_282342   139 -ldANTLKVSSQYAFmkdsPIFVRCYDKDFddnGVMNDCEMSFELGLIGMSKiaetsqIAKMKELAKfyk-nkVIFDLLS 216 Campylobacter je...
Feature 1                                                                                       
O66990      235 TKLSLEIIeffkek----------------gvkitCEVNPNHLLFTEREVlns--------ganARVNPPLRKKeDRLAL 290 Aquifex aeolicus
ZP_00033184 236 SAAGIALMraakae----------------glpvsCDVTVNHVHLIDLDIgyf--------daqFRLDPPLRQQrDREAI 291 Burkholderia fun...
NP_926768   235 TARSVEMAaqakad----------------glpvtASTTVHHLVHASPDLaey--------dpnLRFEPPLGNPaDRAAL 290 Gloeobacter viol...
P72934      258 TARGVELIvqaksq----------------glnctASVNWHHLLLSNEAIahglpphtphydpnLRFDPPLGNEgDRLAL 321 Synechocystis sp...
NP_682323   235 TARSVEILaqgkp------------------eqvsASVSWLHLLFEVEDLany--------dpnLRLDPPLGTAsDRQAL 288 Thermosynechococ...
CAD01099    225 CKSSVELMrwakdk----------------glpvtCDVAMHQLHLTDDNLegf--------namSYVLPPLRSNtDQQAL 280 Psychrobacter sp...
NP_907634   209 NERSLRIIerakee----------------npslfAEVSIHHLAITEDFCsgf--------ntgAKIRPPLKSEsTRKKL 264 Wolinella succin...
NP_861297   224 YPRSFEILqsfraihnktsqknkdsmqfgetpqffTQTSIHHLILDESLCdny--------ntaAKLNPPLVEKnAQSKL 295 Helicobacter hep...
NP_874907   238 TAEGVNMLkkss-------------------pkpmASVFWWHLVADQSTVtst--------digIRVSPSLGSSnDRESL 290 Prochlorococcus ...
NP_282342   217 LKDSLVLLdek----------------------dlKLVSIHHLIKDDSACedf--------ntaAKLMPPLRSKeDVLAL 266 Campylobacter je...
Feature 1                     #                                                                 
O66990      291 IEGVkrGIIDCFATDHAPHQTFEKelv-efaMPGIIGLQTALPSALELYRKgii-slkKLIEMfTINPARIigvdlg-tl 367 Aquifex aeolicus
ZP_00033184 292 RAGLvdGTIDAICSDHTPVDDDEKllpfaeaTPGATGLELFLSLTVKWADEarv-plaKALNRiTAAPAKVleldaagri 370 Burkholderia fun...
NP_926768   291 VAALeaGIIDAVASDHTPWTYEEKtlpfsqaPPGAIALELVLPLVWNLVREgrl-tplRAWEAlSSAPRRIlal------ 363 Gloeobacter viol...
P72934      322 IEGVksGVIDAIAVDHQAFTYEEKtqtfaetPPGAIGYELVLPCLWQGLVEknlitpmALWRAlSTNPRRClgl------ 395 Synechocystis sp...
NP_682323   289 IEGIktGIIEAIAIDHTPLLYEEKmvsfaeaLPGAIGLELALPALWQELVAkeylsalELWHAlSTAPARIlgiepp--r 366 Thermosynechococ...
CAD01099    281 RRGLkdGTIDAICSHHEPLNVTAKkapfaesIPGISNFDTFMALACQLVRDevl-tveQLVAKiCLNPAKIagied---- 355 Psychrobacter sp...
NP_907634   265 LQLLkeGVVDVVTSLQSEHSLSKKdvafeeaAFGVDNIENHFSLCYTYLIKqgrlsmsDLSRVtAKRAAEIlgleskgyv 344 Wolinella succin...
NP_861297   296 IEMLqnGYIDTLTSLQCADFNSKKdqvfelaSFGVDALEIYFPLLYTYLHKayniplpLISQFtSYTPAQIlnlnkg-al 374 Helicobacter hep...
NP_874907   291 KKALqeRILTGVAVHNISLDDAETkkpfseiIPGISGYHLVLPSLWQELIKkskwsveQLWEAiSFGPSKIlslppe--e 368 Prochlorococcus ...
NP_282342   267 REVLkeGKISFLTSLHSAKSISLKdlafdeaAFGIHSVCEFISLCYTFLIKegflnwqELCRFtSKNPSEFlglnsg-vi 345 Campylobacter je...
Feature 1                                                       
O66990      368 klgsPADITIFDPNkewilnee---tnlsksrnTPLWGKVLKGKVIYT 412 Aquifex aeolicus
ZP_00033184 371 avggVADLCVFDRNahwrvepr---alksqghnTPFLGYELPARVHAT 415 Burkholderia fungorum
NP_926768   364 --khPQVLVLFDPDktwvpgtd---tlhsrslaTAWLGRTVQGRVLEV 406 Gloeobacter violaceus
P72934      396 -pevSNSRILFDPDqawtlkrg---tlqtsaynSPWWNHSLKGRVVAW 439 Synechocystis sp. PCC 6803
NP_682323   367 lephSRNFVLFDPSatwtvthq---slrsrarnTPFWQQSLRGQLVPF 411 Thermosynechococcus elongatus BP-1
CAD01099    356 qyleTGGAILVDPDmkwqvtae---tmlsngknTPFFGQQLQGRVVET 400 Psychrobacter sp. TAD1
NP_907634   345 gvgaDADLILVDIKsskvv----------ednfSPYYNSILYGEVERT 382 Wolinella succinogenes
NP_861297   375 qegkIAQLFVFNPHtrfkv----------ndmfSPYHQHNLYGNIEAF 412 Helicobacter hepaticus ATCC 51449
NP_874907   369 lkvgSNRWLLFDPDqkwiqtrkyqekgwetnsnQPWEGIEMIGKIIDC 416 Prochlorococcus marinus subsp. marinus str. CCMP...
NP_282342   346 evgkEANLVLFDENeeif-----------apksSLYSEDKLFGKIKMH 382 Campylobacter jejuni subsp. jejuni NCTC 11168

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