1LK7,1O8B,1M0S,1UJ5,1XTZ,2F8M


Conserved Protein Domain Family
RPI_A

?
cd01398: RPI_A 
Click on image for an interactive view with Cn3D
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the conversion of phosphosugars into glycolysis intermediates, which are precursors for the synthesis of amino acids, vitamins, nucleotides, and cell wall components. In plants, RPI is part of the Calvin cycle as ribulose 5-phosphate is the carbon dioxide receptor in the first dark reaction of photosynthesis. There are two unrelated types of RPIs (A and B), which catalyze the same reaction, at least one type of RPI is present in an organism. RPI_A is more widely distributed than RPI_B in bacteria, eukaryotes, and archaea.
Statistics
?
PSSM-Id: 238692
Aligned: 119 rows
Threshold Bit Score: 176.509
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1LK7_A; Pyrocoocus horikoshii RPI binds Phospho-Erythronic Acid inhibitor; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:1UJ5_A; Thermus thermophilus RPI binds Ribose-5-Phosphate; defined at 3.5A contacts.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                               # ##                                     
1LK7_A         6 MKKIAAKEALKFIed-----------------dMVIGLGTGSTTAYFIKLLGEKLkrg--eisDIVGVPTSYQAKLLAIE 66  Pyrococcus hori...
AAK79399       6 LKKISAKKALEYIkd-----------------nTVIGLGGGETIGYLCDYLKEKIks----gfNIKVVTPSIKTRNTCIE 64  Clostridium ace...
NP_784162      3 IKQAIVQQALTLIkp-----------------qMVVGFGGGSTVGELVKEAANHVn-------DITVVTPSPTTRQLATV 58  Lactobacillus p...
NP_199265     39 PLLRAAHHTVDNYvk----------------sgMIIGLGSGEASDFAIRYLGQQLgsg--slhNVVGVPMSARSASEAAK 100 thale cress
ZP_00911761    6 LKKNSAKEAMKYIkd-----------------gMIVGLGGGRSIAYLIEFIKQDKn------iNVKIVTPSVKTKMLCIE 62  Clostridium bei...
ABE00243       1 MDNVIDLAFNLLHp------------------dTTISLGGGSNVKKLAHKLSQHPe------lNIKVCSPSEYTRQICRD 56  Lactobacillus s...
YP_100954     22 SKEQLARMIAMRVqe-----------------gEIIGAGSGSTVYLALLAIAERIrte---nlHVTVIPASMEISMECVR 81  Bacteroides fra...
BAE95210       9 MLESAVYEHVRDG--------------------MIIGLGSGRTVAALLDVLARMSrsmgidmaSIRFIPTSLQIKMKAEE 68  uncultured cren...
NP_001051457  38 RRRAVTCAAAADAdvvglfdaakltvdrfvesgMVVGLGSGPASGLAIQYLGTRLrrg--sltGILGIPSSTISASEAVK 115 Japanese rice
NP_810899     22 AKERVAREIAATAkt-----------------gDVIGAGSGSTVYLTLFELAKRIhee---hlYLEVIPASQEISMTCIQ 81  Bacteroides the...
Feature 1                            ## #          ####           #                 #            
1LK7_A        67 H--DIPIASLdqVDAIDVAVDGADEVdp-nLNLIKGRGA------ALTMEKIIEYRAGTFIVLVDERKLVDYlcqkmpVP 137 Pyrococcus hori...
AAK79399      65 N--GIEVLYTssVEHLDVAFDGCDQLde-kLNALKSCGG------IHSKEKIIASMADKYILLTNESKFVKKldstypIV 135 Clostridium ace...
NP_784162     59 L--GYTVVDTayCDRVDIAFDGCDQLdh-hGNALKSGGG------IHANEKIIASLADEYWLLTMQDRLVDQfdiktpLV 129 Lactobacillus p...
NP_199265    101 Y--GIPLEYYrdGVQIDFAFHDADAVeentLIAVIGRRRssqeddYILKQKSIVKVADEAVFMIKEEQYKAGle--gsIP 176 thale cress
ZP_00911761   63 K--GLEVLYTssVDKVDVAFDGCDQVde-kLNALKSGGG------IHTKEKLIASMAEEYILLVDEAKVEKEltfnvpVV 133 Clostridium bei...
ABE00243      57 L--NLNLIDIteASTIEFGFDGCDAIdf-dLNVLKSNGG------IHTLEKEYAYKAEKYIIISPPERLKASlnpnvqLC 127 Lactobacillus s...
YP_100954     82 L--GIPQTTLw-MCRPDWTFDGADEVdp-dHNLIKGRGG------ALFKEKLLICSSNRTFILVDESKQVSFlgsrfpVP 151 Bacteroides fra...
BAE95210      69 LkmSIGDESL--IPSVDLVFDGADQIdansLVMIKGGGG------ALLREKVLMYAAKKVVILADESKYVDKlt--lpIP 138 uncultured cren...
NP_001051457 116 A--GIQVSSYeeGTQIDFAFTDADIIeedtMTAVIGRRKtesgepSFMVEKGIVKSADKLAFIIGHEKYVKGie--gsIP 191 Japanese rice
NP_810899     82 L--GIPQTTLw-DKRPDWTFDGADEVdp-dRNLIKGRGG------AMFKEKLLIRSSGKTFIIVDPSKLVNIlgskfpIP 151 Bacteroides the...
Feature 1                                                                                        
1LK7_A       138 IEVIPQAWKAIIEELSif--naKAELRMgvn-------kdgPVITDNGNFIIDAKfpri-ddpLDMEIELNTIPGVIENG 207 Pyrococcus hori...
AAK79399     136 LEILEESAGYVKRRISei--ggKATFRSsaa-------kdgFTITDSGNLLLDVFfdel-gdaKELQKGLKGITGVVETS 205 Clostridium ace...
NP_784162    130 LEVLPAALSLVMRTVSdl--ggQATIRTann-------rdgFTLTDSGNLLIDCHfpty-aklTDLNVELATLAGVVETS 199 Lactobacillus p...
NP_199265    177 VLVQSLNWLAIAEEIDdlylgdAEVWRRasvenegplggdfPIVTSDGHNILDVIfttpirslADLATSLDKIDGVVDHG 256 thale cress
ZP_00911761  134 LEVLEDSLKYVEKKVLel--ngKPVIRSsdi-------kdgFTISDNGNLLVDVFfnnv-kdiHKLNDNLIRICGVIETS 203 Clostridium bei...
ABE00243     128 LEVVFPSVDSVLFAAKql--glKAELRLgsa-------vasYARTPLGNYLIDCYcesw-qdiKKINSKLSSLNGVVSTS 197 Lactobacillus s...
YP_100954    152 IEVFPMALPYVEREVLtmg-alRTELRLakg-------kdgPVITENGNLILDAWfgn---ihSSLEKEIKSITGVVENG 220 Bacteroides fra...
BAE95210     139 IEVVPYARAYVSNMLRsm--yaEPSVRVndr--------gyPIMTENGNIIIDTVfssi-edpYNLEHRLKCIPGVVEVG 207 uncultured cren...
NP_001051457 192 VLVKSANWIDTAEEIDdlflgdAEVWRRpsigtagplggdfPLVTKEGHHVLDVIfttpipdlGKVAESLEKIAGVVDHG 271 Japanese rice
NP_810899    152 VEVFPHALSYVEKELRrlg-asEISLRPahg-------kdgPILTENGNFILDTRfhy---idASLEEQLKTITGVIESG 220 Bacteroides the...
Feature 1                     
1LK7_A       208 IFADiADIVIVGT 220 Pyrococcus horikoshii
AAK79399     206 LFVDlVSQAIIAY 218 Clostridium acetobutylicum ATCC 824
NP_784162    200 YFDHlVTNAWLGD 212 Lactobacillus plantarum WCFS1
NP_199265    257 LIIKtRCTVVIAE 269 thale cress
ZP_00911761  204 LFTNvITKVIIAS 216 Clostridium beijerincki NCIMB 8052
ABE00243     198 YFENiVHSVLTLD 210 Lactobacillus salivarius subsp. salivarius UCC118
YP_100954    221 LFMGyDVEVMVAK 233 Bacteroides fragilis YCH46
BAE95210     208 LFSKaADLYYKAR 220 uncultured crenarchaeote 31-F-01
NP_001051457 272 IVSSiPSYVVVAL 284 Japanese rice
NP_810899    221 LFIN-YDIEVVVT 232 Bacteroides thetaiotaomicron VPI-5482

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap