1FQO,2BKX,1NE7,1NE7,1FSF


Conserved Protein Domain Family
GlcN6P_deaminase
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cd01399: GlcN6P_deaminase 
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GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.
Links
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Statistics
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PSSM-Id: 238693
Aligned: 109 rows
Threshold Bit Score: 203.871
Created: 15-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1FQO_A; Escherichia coli GlcN6P-deaminase binds fructose-6-phosphate; defined at 3.5A contacts.
    - View structure with Cn3D
  • Citation:PMID 8747459
  • Structure:2BKX_B; B. subtilis GlcN6P-deaminase binds fructose-6-phosphate; defined at 3.5A contacts.
    - View structure with Cn3D
  • Structure:1NE7_F; Human GlcN6P-deaminase binds glucitol-6-phosphate; defined at 3.5A contacts.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ####                          ##                 
1FQO_A       10 EQVGKWAARHIVNRInafkptadrpFVLGLPTGGTPMTTYKALVEMhkagqVSFKHVVTFNMDEYVgLPKEHpesYYSFM 89  Escherichia coli
NP_484770    22 ADMAQDVAAIVRKYLqslle-ekktAAVLLATGNSQLKFLDALIALg---gVDWSRITLFHLDEYLgITADHpasFRRYL 97  Nostoc sp. PCC 7120
ZP_01168696  23 DDMGRAAAADIAGQIvklqk-eqgeIRMVFAAAPSQNEVLDYLIQDs---rIRWEDMTAFHMDEYIgLPNDApqlFQNFL 98  Bacillus sp. NRR...
ZP_00519340  21 EKLAIAAAKIGESYLqevlk-nqkeATILLATGNSQLKFLDRVIADq---tIDWSRINLLHLDEYLgIEGNNsasFRFYL 96  Crocosphaera wat...
ZP_00234891  10 KEMSQEALEVVEQVInen-----dnPVINTTTGASFDGMFEGLVKGinageIPIERVFLMNLDEYV-AKRDAsftVYTYM 83  Listeria monocyt...
AAT75387     10 ESMTDKTIEAFMEILeknk--hkerINVSVTGGNSPKLFYSKIISIln-elAYLDKIHFYNFDEVPfRNDLStgiTSKDL 86  Mesoplasma floru...
NP_814235    10 DTMSEWAKMLLLSTMsqd-----krVNLSITAGKTPALVYQKLASIvk-nsSDFDNVHYYNFDEIP-VPHQKegiTLTDL 82  Enterococcus fae...
CAD00934     10 ENMSKTTMQLLLGKMyqd-----kkVHLAITAGSTPKRMYELMVEEmk-ekAPLKNVSYYNFDEIP-IGDEKygvTIANL 82  Listeria monocyt...
YP_543227    10 QEMSRVAAQHLLGYMskt-----rrVNLAITAGSTPKGMYEYLITLvk-gkPWYDNCYFYNFDEIPfRGKEGegvTITNL 83  Escherichia coli...
ZP_01353310  18 EEMGEAAAREASECIkkllq-ekdvINCMFAAAPSQNEFLVALVNDk---nIPWHRINAFHMDEYMgLEEGDsrtFRAFL 93  Clostridium phyt...

Feature 1                                                       ##    # #                       
1FQO_A       90 HRNFFDHv-DIPaeNINLLNgnapdidaeCRQYEEKIRsygKIHLFMGGVGNDGHIAFNEPASSLa---SRTRIKTLTh- 164 Escherichia coli
NP_484770    98 RERVEKRv-FPQ--QFHYIEgdtleplaeCDRYTKLLQa-qPIDLCCLGVGENGHLAFNDPSVANfqdpYSVKLVKLDp- 172 Nostoc sp. PCC 7120
ZP_01168696  99 KERLFDKv-SFK--QVHLINssd---keeVERYTRLLQe-aPIDIVCLGIGENGHIAFNDPPVADfedeHMIKKVELEd- 170 Bacillus sp. NRR...
ZP_00519340  97 HEKVEKRi-NSK--SFNYLNgdalepieeCDRYTKLLQq-yPIDLCLLGVGLNGHLAFNEPQVANfndtYKVKIVKLDp- 171 Crocosphaera wat...
ZP_00234891  84 HQKFYDLinKMPk-RVELLDgsladftdeIARYKKILAe-nERDLQILGLGVNGHLGANEPGTPFd---ARLFLADSDe- 157 Listeria monocyt...
AAT75387     87 EELLFSKa-KIKqkNIHRLNvl------nYKEYIDQLYkdgGLDVVLLGIGIDGHFCGNMSGVTKf--gDKTRLINNI-- 155 Mesoplasma floru...
NP_814235    83 RTLYLTPa-EISeqNIHPLTve------nFQQQEQRIAdagGLDLMLIGLGADGHFCGNMPTTTHf--kNETYQVTVT-- 151 Enterococcus fae...
CAD00934     83 KAMYFDPa-GIPeeQIHMLDtk------nYVEHEARLKevgGLDAILIGIGEDGHFCGNLPGVTKf--gDETRLVSVQ-- 151 Listeria monocyt...
YP_543227    84 RNLFFTPa-GIKeeNIQKLTid------nYREHDQKLAregGLDLVVLGLGVDGHFCGNLPNTTH----FHEQTVEFPiq 152 Escherichia coli...
ZP_01353310  94 KKAIFDKv-PFN--QIFLINgeke-peeeCERLEAIMKe-hPLDIVFMGIGENGHIAFNDPPVADfkdpKNIKIVELEe- 167 Clostridium phyt...

Feature 1                 #                                       #                             
1FQO_A      165 ---dTRVANSRFFDNdv----nQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHmWTISCLQLHpKAIM 237 Escherichia coli
NP_484770   173 ---vNRQQQVNTGQFph---ldSVPQYAFTVTLPLICSAKKIFCLAPEQRKAQIVKQMLQGSIRTtCPASVLRQQpQATL 246 Nostoc sp. PCC 7120
ZP_01168696 171 ---aCRQQQVNDGCFss---leDVPLYAFTLTIPALLAAGSMYCAVPGRTKAEAVRQTLNGPISTaCPATILRTHaQAKL 244 Bacillus sp. NRR...
ZP_00519340 172 ---qTRQVQVNQGHFst---ldQVPKYALTLTIPTIMSAKKILCLALGENKAEIIRQTLKGEISTlCPASILRQHsHATL 245 Crocosphaera wat...
ZP_00234891 158 ---sTIKSTIMYNNLke----dEAPSQMLTLGLADMMDAKQILVTASGERKAEAVKGLLEGPIDEnCPASILRNHpNVVF 230 Listeria monocyt...
AAT75387    156 ----DLEGNISVPKLdl----nLFHDQFVTMGPRDIMAARNIIMIANGKGKAEVIDQIVNGPVIEkVPSSILTLHpFFTL 227 Mesoplasma floru...
NP_814235   152 ----GSEPWFVPEMM-------QPGMTFVTMGPASIMKVKHLVLIVNGEQKAQMVKQVLQGPVTEtYPASILQLHpNLTV 220 Enterococcus fae...
CAD00934    152 ----SRPDMFDILLGevggdveKVPEYYVTMGPKSVMHAKEVILFANGKKKAAIIKKALQGPVTEdIPSSIFQLHpNFTV 227 Listeria monocyt...
YP_543227   153 gemvDIVAHGELGGDf-----sLVPDSYVTMGPKSIMAAKNLLIIVSGAGKAQALKNVLQGPVTEdVPASVLQLHpSLMV 227 Escherichia coli...
ZP_01353310 168 ---nCRKQQVNDKCFes---ldEVPKNALTVSIPKLMQANHIFCIVPGILKAQAIKGTFLGPINEsCPASILRRHdNAHV 241 Clostridium phyt...

Feature 1                  
1FQO_A      238 VCDEp-STMEL 247 Escherichia coli
NP_484770   247 FLDIn-SANLL 256 Nostoc sp. PCC 7120
ZP_01168696 245 YLDKdsFGDEQ 255 Bacillus sp. NRRL B-14911
ZP_00519340 246 LLDKk-SAAFL 255 Crocosphaera watsonii WH 8501
ZP_00234891 231 IIDEa-AGALL 240 Listeria monocytogenes str. 1/2a F6854
AAT75387    228 ILDEe-ANSIA 237 Mesoplasma florum L1
NP_814235   221 LLDEa-AASQL 230 Enterococcus faecalis V583
CAD00934    228 VLDEe-AASEL 237 Listeria monocytogenes
YP_543227   228 IADKa-AAAEL 237 Escherichia coli UTI89
ZP_01353310 242 YVDKd-SASKL 251 Clostridium phytofermentans ISDg

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