1PBT,1Y89,1VL1


Conserved Protein Domain Family
6PGL
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cd01400: 6PGL 
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6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.
Links
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Statistics
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PSSM-Id: 238694
Aligned: 160 rows
Threshold Bit Score: 155.028
Created: 15-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Structure:1PBT_A; Thermotoga Maritima 6PGL binds sulfate ions; defined at 3.5A contacts.
    - View structure with Cn3D
  • Structure:1Y89_B; Vibrio cholerae 6PGL (Devb protein) binds sulfate ions; defined at 3.5A contacts.
    - View structure with Cn3D
  • Comment:This putative active site superimposes with the active sites of other members of the family.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            ##                            #            
1PBT_A       28 IYLLEDgyVDFVVEKIRTKXeklleekdkIFVVLAGGRTPLPVYEKLAEQk---FPWnRIHFFLSDERYVPldsDQSNFR 104 Thermotoga maritima
1VL1_A       18 IYLLEDgyVDFVVEKIRTKMeklleekdkIFVVLAGGRTPLPVYEKLAEQk---FPWnRIHFFLSDERYVPldsDQSNFR 94  Thermotoga maritima
XP_629423    14 ERFEDEc-VKFIKNVITDSInsr----niATIGLSGGSTPKPIYEMLGNDs--sIDWtKVYFFAVDERYIDkssKDSIYD 86  Dictyostelium di...
CAI75777    107 EGFVLTa-SHLILHKIRRKLsksp--dvtVKIGLSGGSTPRGIYRFLGNMkdldIDFnRIIFFLVDERYVPsddEMSNIR 183 Theileria annulata
O18229       24 KELILQl-RRYLEEKLTYLLdqn----gtVSIGVSGGSMPRVFSKAILSLpqeqLNWkRIRIFMVDERNVDldsEESNQG 98  nematode
YP_757865    18 VAMADAl-AGSIATTLANAIrer----geAVLAVSGGSTPEALYKRLAKAd---LDWsRVCVVLVDERWVEpgeAGSNET 89  Maricaulis maris...
ZP_01303951  11 AQAAADi-ADRIATILSDAIavr----giATIALSGGRSPRPVLEALSLAt---LDWsKLIVTLVDERWVDaasADSNER 82  Sphingomonas sp....
ZP_01305840  16 HGLAQGl-GIMLESAIEESLash----spAMIALSGGSTPRTFLKHLCHQh---LPWqDIVWTPVDERFVPvdhQDSNEK 87  Oceanobacter sp....
YP_760443    13 AASVLA--AELASLHLSRAIakd----ghASFMVSGGSSPARMLSLLSQDa---LDWaSVTVGLVDERWVSpdhPGSNEK 83  Hyphomonas neptu...
NP_212356     6 SDEENYl-KDRFFDFFNMNVdkd----kyTSIGICGGRSIVNFLSVFLKQn---FSFrRSHFFLVDERCVPlndENSNYN 77  Borrelia burgdor...

Feature 1                                                                                       
1PBT_A      105 NINEVLFSRAkip----sgnVHYVDtslp-----iekACEKYEREIrsa------------------------------- 144 Thermotoga maritima
1VL1_A       95 NINEVLFSRAkip----sgnVHYVDtslp-----iekACEKYEREIrsa------------------------------- 134 Thermotoga maritima
XP_629423    87 LISKSVFKNRenll---vdhFITPNtslp-----lkeCIETYSNDLkklie----------------------------- 129 Dictyostelium di...
CAI75777    184 LLRNTLLKHWpvpe---snlVFPDTslp------leeCVKKYEADLeavfgvvtthvnsntdpahrvagksemsstefes 254 Theileria annulata
O18229       99 EYLRLFPNELrd-------vFVPMQifkd-----pclTAQHYEISLrkyllpe--------------------------- 139 nematode
YP_757865    90 FLRSTLMTDRaak----armVGLKApget-----pldGLVDVTERLsdi------------------------------- 129 Maricaulis maris...
ZP_01303951  83 LVRDTLLRGPaaq-----arFVPMKt----------dAADAYAGQPdveraf---------------------------- 119 Sphingomonas sp....
ZP_01305840  88 MFRELLIEHHpet-----hfLSMIQhqe------leqSVQLYQKRFhtf------------------------------- 125 Oceanobacter sp....
YP_760443    84 GVREKLLKGPaaa-----arFIPMKtddadpasavadRAAAYAPHVl--------------------------------- 125 Hyphomonas neptu...
NP_212356    78 LLNKNFFSKMvdknlisiskFHAFVysei----deatAIHDYNIEFnsr------------------------------- 122 Borrelia burgdor...

Feature 1                                #                                        #             
1PBT_A      145 ----------tdQFDLAILGXGPDGHVASIFDLetg--------nkDNLVTFTDpsg----dpkVPRVTLTFRALNTSLY 202 Thermotoga maritima
1VL1_A      135 ----------tdQFDLAILGMGPDGHVASIFDLetg--------nkDNLVTFTDpsg----dpkVPRVTLTFRALNTSLY 192 Thermotoga maritima
XP_629423   130 --------ksngSPDLVTLGMGEDGHIASIFPNspks-----pldeTDLVYHTTter----faiFDRITTNINFLASSKN 192 Dictyostelium di...
CAI75777    255 fdhsfykpkysiVPDLVTLGIGEDFHIAGLFPEylstldssyvtdtLHRVMATYtet----tvvRERISCSLPFLSCAPT 330 Theileria annulata
O18229      140 ------qlnntaRFDILFLGVGPDGHTASIFPGkerle----kiteLNWVSVITdsp----kppPSRITLTLQTLQHAKN 205 nematode
YP_757865   130 ----------hfPPDVVILGMGDDGHTASWFPRsdglda--alaeaGPPVCAIRakqtavtgslTDRITLTRAALAGAGL 197 Maricaulis maris...
ZP_01303951 120 -------aalpwPLDIILLGMGDDGHTASLFPEgrela---eglatDALTIAATppa-----apHQRLSLTASAILKSRH 184 Sphingomonas sp....
ZP_01305840 126 ----------gkTYDVCILGMGNDGHTASLFPDapelsq--aikkdADCFMAMHpqs-----avQARISAGLETIMQSKV 188 Oceanobacter sp....
YP_760443   126 ------------PISCILLGIGPDAHTASWYPGsmgldq-amypeeGAIIAAVDagntpvsgdfHQRMTLTAGPICSAAS 192 Hyphomonas neptu...
NP_212356   123 ----------fnIFDFIIVSVGEDGHIASLFPSrkll-----fsdvEGYQYEYNspk-----fpSKRISLTPKSLFGSKA 182 Borrelia burgdor...

Feature 1                #                                     
1PBT_A      203 VLFLIRGKEKINRLTEILkd-----tpLPAYFVrgk----ekTVWFV 240 Thermotoga maritima
1VL1_A      193 VLFLIRGKEKINRLTEILkd-----tpLPAYFVrgk----ekTVWFV 230 Thermotoga maritima
XP_629423   193 KVFFMSGSSKKKVWDEMEssqi-nvsrWPAHKIiss----gnTNVFY 234 Dictyostelium discoideum AX4
CAI75777    331 KLFFLKGERKKRIWNTMLqyrhydpirFPATQIftk---pgcIAVLD 374 Theileria annulata
O18229      206 VAFIICGKQKAEIVRGICdrd----qkYPAAQArpf---ndkLTLFL 245 nematode
YP_757865   198 SLLLIAGEGKKAALEAALgdgp--vadMPVRALlrsqsdrpdIHWTR 242 Maricaulis maris MCS10
ZP_01303951 185 IFLQISGASKKAVYDRALaggp--veeLPIRLAllqd-dvpvEVWIA 228 Sphingomonas sp. SKA58
ZP_01305840 189 RILHIQGEEKKRTFTKALavtn--paeMPIRWVceq---plhVFWCP 230 Oceanobacter sp. RED65
YP_760443   193 AILLMFGEDKRSALEQSLkgd---ekqFPVRRAieglgrrlsIIWAP 236 Hyphomonas neptunium ATCC 15444
NP_212356   183 VVLLFMGVDKKCALENFLasns-sineCPARLLkeh----pnLLVLT 224 Borrelia burgdorferi B31

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