Conserved Protein Domain Family
TCCD_inducible_PARP_like
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cd01439: TCCD_inducible_PARP_like 
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. TCCD indicible PARP (TiPARP) is a target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation
Links
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Statistics
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PSSM-Id: 238719
Aligned: 17 rows
Threshold Bit Score: 126.665
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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nad+ binding
Feature 1:nad+ binding pocket [chemical binding site]
Evidence:None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #####  #   #     ### #            ###         #                               
NP_056323  529 HLFHGTSQDVVDGICKh--NFDPRVcgkhatmFGQGSYFAKKASYSHNFSkkssk--gvhfMFLAKVLTGRYTMGshgmr 604  human
Q9H0J9     561 QLFHGTSAIFVDAICQq--NFDWRVcgvhgtsYGKGSYFARDAAYSHHYSksdt---qthtMFLARVLVGEFVRGnasfv 635  human
CAF98285   570 YLFHGTDESLVEAICEq--NFDWRVcgthgtvYGKGSYFAKDASYSDQYSrissr--rnkiMFVALVLVGDSTQGrssyv 645  Tetraodon nigrov...
CAF96305   731 KLFHGTDNQYVDTICHt--NFDWRLcgshgtaFGKGYYFAQNAKYSHSYTsdsn----vrsMFVVRLLVGEYTKGspeyr 804  Tetraodon nigrov...
AAM18473   153 LLFHGTSSDSITQINNh--GFNRSYagthgaaIGNGSYFAVNSSYSARGYskada-qgnkrMYLARVLVGDYTQGqagli 229  rainbow trout
BAC05197   322 LLFHGTDADSVPYVNQh--GFNRSCagknavsYGKGTYFAVDASYSAKDTyskpdsngrkhMYVVRVLTGVFTKGraglv 399  human
CAG05989    32 TLYHGTSEESMKEICLh--GFNRSFcgknatvYGQGVYFAVNSAVSLNDRysppnadghkfVFVSRVLTGDYTKGcssmk 109  Tetraodon nigrov...
AAS38928  1480 YLFHGTSATQPESIYNsknCFDWRFske-scmWGNGSYFAYNASYSHRYSyktpq--klnqIFIATVLIGDSITSepdss 1556 Dictyostelium di...
XP_378197  884 VLYHGTTAPAVPDICAh--GFNRSFcgrnatvYGKGVYFARRASLSVQDRysppnadghkaVFVARVLTGDYGQGrrglr 961  human
NP_113646  702 RLFQQVPYQFCNVVCRv--GFQRMYstpcdpkYGAGIYFTKNLKNLAEKAkkisaadkliyVFEAEVLTGFFCQGhplni 779  human

Feature 1                                 #                    
NP_056323  605 rppp-vnpgsvtsDLYDSCVDnffEPQIFVIFnd---dQSYPYFVIQY 648  human
Q9H0J9     636 rpp---akegwsnAFYDSCVNsvsDPSIFVIFek---hQVYPEYVIQY 677  human
CAF98285   646 rp----ppkgnskAFYDSCVNsesNPSIYVIFek---qQIYPEYLINY 686  Tetraodon nigroviridis
CAF96305   805 rpp---skdggdiNFYDSCVDdvhTPSIYVVFdk---hQIYPEYLLQY 846  Tetraodon nigroviridis
AAM18473   230 vpp--akpsgkdaDLYDSVTDntsNPTMFVIFsd---vQAYPEFLIHS 272  rainbow trout
BAC05197   400 tpp--pknphnptDLFDSVTNntrSPKLFVVFfd---nQAYPEYLITF 442  human
CAG05989   110 aap--lkpgsdvpFRYDSVTNnmdNPKIFVIFsd---tQAFPQYLITC 152  Tetraodon nigroviridis
AAS38928  1557 lklpplkdstnknVRYDSVKG---NPLGSDIYivydnqQSYPYYLVTY 1601 Dictyostelium discoideum
XP_378197  962 app--lrgpghvlLRYDSAVDcicQPSIFVIFhd---tQALPTHLITC 1004 human
NP_113646  780 vpp---plspgaiDGHDSVVDnvsSPETFVIFsg---mQAIPQYLWTC 821  human

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