1Q0P


Conserved Protein Domain Family
vWA_complement_factors

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cd01470: vWA_complement_factors 
Click on image for an interactive view with Cn3D
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred commonly as the MIDAS motif. Orthologues of these molecules are found from echinoderms to chordates. During complement activation, the CCP domains are cleaved off, resulting in the formation of an active protease that cleaves and activates complement C3. Complement C2 is in the classical pathway and complement B is in the alternative pathway. The interaction of C2 with C4 and of factor B with C3b are both dependent on Mg2+ binding sites within the VWA domains and the VWA domain of factor B has been shown to mediate the binding of C3. This is consistent with the common inferred function of VWA domains as magnesium-dependent protein interaction domains.
Statistics
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PSSM-Id: 238747
Aligned: 13 rows
Threshold Bit Score: 287.262
Threshold Setting Gi: 2133785
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:metal ion-dependent adhesion site (MIDAS)
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # # #                                                                    
1Q0P_A     16 MNIYLVLDGSDSIGASNFTGAKKSLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNad----wVTKQLNEINY 91  Homo sapiens
I50807    256 THIYLVIDASYSVGKEDFDTGLNFVKDLINRIGMYVRNIRYSIVMYATNPSLKLSVRDSWSNDpn----aVIKILDDLDY 331 Japanese lamprey
P06681    253 LNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDmt----eVISSLENANY 328 human
P04186    266 MNIYLVLDGSDSIGSSNFTGAKRCLTNLIEKVASYGVRPRYGLLTYATVPKVLVRVSDERSSDad----wVTEKLNQISY 341 house mouse
BAA34707  340 LNVFILLDTSASISPESFHLAKNATIQLVQKLDSYEVTMRFGIISYASEAKEIVSITNDLSQDvh----yVMRKLHEFSD 415 common carp
I51579    240 MNIFIVLDTSKSVGQNRFDEAKSASILFIEKMSNYDIKPRYCIISYASKAISVVSLRDPDSNNad----aVMEHLEEFQY 315 African clawed frog
AAB19093  257 LDIYIAVDASDSIDPKDFDKAKKIIKTLIEKISYYEVSPNYEILMFATDVDQIVKMRDFKTNEkarkilkIFEDLDNFNY 336 zebrafish
AAC83699  231 LNIYIAMDISDSIAEEDFNSARNAVKKLITKVSSFSVSPNYEIIFFASDVLEVVNIIDFSGDKrkp-lvdVLAELNNFKY 309 rainbow trout
BAA12207  252 LNIYIALDISESVEEEHFKRAKLAIITLIKKIAAFTVSPNYEILFFSADVYEVVSIVEFYEGKitl--esAIKNLEDFQI 329 Japanese medaka
CAD21938  254 LNIYIAVDISESIQKDHVESAKKAILKLITKISSFSVSPNYELLFFSSELSEVVNILDFFENQpv----dIKGRLTKFKV 329 Tetraodon nigrovir...
BAB32650  250 LDIYIALDVSDSIDEEDFEKAKGVIKTLIEKISYYEVSPNYEILIFATDVARIVSMRDFKSAQknn-lleILKRLKDYEY 328 common carp
BAB19788  272 MNVFILMDTSGSISKTHFNLARGAIADLIRKLDSYEIELNFQVISYASQAKDIVDIVSSNDEHvrsnvrsVLKRLAAFDH 351 rainbow trout
BAB63203  254 LHVYILLDASESVGEEYFSEAKNVAENLIDKIASFDVWPRFGVISYASDPVVIANLYDDNESSad----dAIGLLRKATY 329 Triakis scyllium
Feature 1             #                                         #                             
1Q0P_A     92 EDHklksGTNTKKALQAVYSMM-----SWPDDv-pPEGWNRtRHVIILMTDGLHNMGGDPITV-IDEIRDLLYigkdrk- 163 Homo sapiens
I50807    332 YEFddtpGTNTAMALKMVLDTM-----ALYKVa-nQNTFKDiRQAIILLTDGRSNVGPPPGKFlMDNIDLDIPke----- 400 Japanese lamprey
P06681    329 KDHengtGTNTYAALNSVYLMMnn-qmRLLGMe--TMAWQEiRHAIILLTDGKSNMGGSPKTA-VDHIREILNinqk--- 401 human
P04186    342 EDHklksGTNTKRALQAVYSMM-----SWAGDa-pPEGWNRtRHVIIIMTDGLHNMGGNPVTV-IQDIRALLDigrdpk- 413 house mouse
BAA34707  416 KSHgnkrGTNLHDALNKVYEEL-----ALLREn-kRSHFNEtQNVIIIATDGYSNMGPSPINI-LPKIRNLFGykssvd- 487 common carp
I51579    316 DRHedkqGTNTRAALHAIYEHLieqelAYEREg-kKEDFMKiHNVILLMTDGKFNMGGDPREE-MKLIKRFLDvgirkd- 392 African clawed frog
AAB19093  337 DKKgdrtGTNIAKLYLKILDSM-----SLEQVq-nKEDFLQtQHVIIVFTDGQANMGGNPKPK-VDLIKNLVIknnas-- 407 zebrafish
AAC83699  310 DARdn-vGTNLNLAFKTILERM-----AIQKKr-nEMLFMEiHHVLIFFTDGAYNMGGSPENT-MAKIRESVYmnnkt-- 379 rainbow trout
BAA12207  330 GDKs--tGTDVNAALKKFEEGMa----WIEQKt--GDKFSEhRHVFLLFTDGAYNMGGSPLPT-LARIKNRVYmsptgdp 400 Japanese medaka
CAD21938  330 NAEh--tGTDLNLAFKTILERM-----ALIKQrvgEKAFEEhRHAIIVFTDGVYNMGGSPLPT-VAKIKHMVYmnkidee 401 Tetraodon nigrovir...
BAB32650  329 NSKgdrtGTNIAQAYRSILESM-----QIEQMt-nKEEFKTtQHIVIMFTDGQANMGGNPRPW-VDQIKDLVKknsps-- 399 common carp
BAB19788  352 RSHgnktGTNLYAALYRVYERM-----AILREr-nETRFSEtQNVILIETDGYSNTGGSPLAV-LAKIRSLLGystsald 424 rainbow trout
BAB63203  330 EIHgdgrGTNIYAALKKVFETM-----VLTKVq-fKDSWDKiRFVTVLFTDGKANMGGNPKAA-VQDIKDFVNaqnk--- 399 Triakis scyllium
Feature 1                                                           
1Q0P_A    164 ---npredyLDVYVFGVGPLVn-QVNINALASKKDneqHVFKVKDMENLEDVFY 213 Homo sapiens
I50807    401 --------hMDVYVFGMGDVY--KDEIETIASQKPneqHSFILRDYDDLNEVFE 444 Japanese lamprey
P06681    402 -----rndyLDIYAIGVGKLDvdWRELNELGSKKDgerHAFILQDTKALHQVFE 450 human
P04186    414 ---npredyLDVYVFGVGPLVd-SVNINALASKKDnehHVFKVKDMEDLENVFY 463 house mouse
BAA34707  488 ---htkeelLDVYVFAVGQQVn-KQELQSIASIKKderHVFVLKDYRQLGLVFN 537 common carp
I51579    393 ---npreeyLDVYVFGLGSDId-QPEINDLASKKEkevHTFHLQNVEKMKEFFE 442 African clawed frog
AAB19093  408 -----renkLDLYVFGVGKDVk-KEDMNGLVSEKKderHFFKLPDLDEVQNTFD 455 zebrafish
AAC83699  380 ----krekyLDVYVFGVGSDIf-DEDIMPLVTKRNgerHYFKLKNVIDLERTFD 428 rainbow trout
BAA12207  401 ---gsrldyLESYVFGIGANIf-DDDLLPLTAGTEgelHYFRLKKETNLAATFD 450 Japanese medaka
CAD21938  402 tgqnprdeyLDIYIFGIGAEIy-DSDLRPLTAGTGg-eHFFKLLEIQNLQETFD 453 Tetraodon nigroviridis
BAB32650  400 ----eeeenLDLYVFGMGDDVn-AEDINDLKTDRGnekFFFKLKNLEDLQETFD 448 common carp
BAB19788  425 ---htedklLDVYVFGVGDNVn-KNELNLIASRKRhekHLFILKDYKQLGEVFN 474 rainbow trout
BAB63203  400 -----sedyLDMYAFGVSDDVy-MPELNDLASQKPnerHCFKIQNTSELVKSFD 447 Triakis scyllium

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