1DK4,1G0H,1LBV,1VDW


Conserved Protein Domain Family
Arch_FBPase_1

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cd01515: Arch_FBPase_1 
Click on image for an interactive view with Cn3D
Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family (FBPase class IV). These are Mg++ dependent phosphatases. Members in this family may have both fructose-1,6-bisphosphatase and inositol-monophosphatase activity. In hyperthermophilic archaea, inositol monophosphatase is thought to play a role in the biosynthesis of di-myo-inositol-1,1'-phosphate, an osmolyte unique to hyperthermophiles.
Statistics
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PSSM-Id: 238773
Aligned: 10 rows
Threshold Bit Score: 328.183
Threshold Setting Gi: 21466040
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                      ##              
1DK4_A        3 WDEIGKNIAKEIEKEILPYfgrkdksYVVGtspsGDETEIFDKISEDIALKYLKSLn--VNIVSEELGVIDns-----se 75  Methanocaldococc...
1G0H_A        3 WDEIGKNIAKEIEKEILPYfgrkdksYVVGtspsGDETEIFDKISEDIALKYLKSLn--VNIVSEELGVIDns-----se 75  Methanocaldococc...
1LBV_A        6 ALRISREIAGEVRKAIASMplr-ervKDVGmgkdGTPTKAADRVAEDAALEILRKEr--VTVVTEESGVLGeg------d 76  Archaeoglobus fu...
1VDW_A        6 WRKIAIDIIRDFDHNIMPLfgnpkasETISispsGDETKVVDKVAENIIISKFKDLg--VNVVSEEIGRIDqg-----sd 78  Pyrococcus horik...
Q58327        6 GFKIAMKVIDEIDKKIKPLigwekadEVVKigadGTPTKRIDVIAENMAINILEKFs-gGILISEEIGLKVvgd---ele 81  Methanocaldococc...
NP_618233     7 FLKLCREAYRAAYDATCDLvgtdsasSFVCmgadGTPTTCIDLAAEDAIIEVLKTDgrpMRILSEELGELVtgk---spe 83  Methanosarcina a...
O26957        9 WKGVAVRMAEQVERAVSPLvgtedagEIIKmgadGTPTKLIDLVAEDEAVGVLESTgrpVTIISEEIGVLHinsegdepg 88  Methanothermobac...
AAM48105      6 WREVAIDIISDFETTIMPFfgnpdggKLVKispsGDETKLVDKLAEDLILSRITELg--VNVVSEEVGVIDne-----se 78  Pyrococcus furiosus
ZP_00148789   7 ILEFCDLLAESASNAISDIvgteeafRTVYvgadGTDTKLIDDVSEKAIIEILKADgrsIRLLSEELGEVVfgd---dpe 83  Methanococcoides...
NP_988609     3 MLEMALNIAKDIEKSVKPLigweksnEVVKigadGTPTKRIDLIAENVAINSIEKVc-sAILISEEIGFKRigkn--kpe 79  Methanococcus ma...
Feature 1            #### #                                                                     
1DK4_A       76 WTVVIDPIDGSFNFINGiPFFAFCFGVFKNNE----------------------------PYYGLTYEFltKSFYEAYkg 127 Methanocaldococc...
1G0H_A       76 WTVVIDPIDGSFNFINGiPFFAFCFGVFKNNE----------------------------PYYGLTYEFltKSFYEAYkg 127 Methanocaldococc...
1LBV_A       77 VFVALDPLDGTFNATRGiPVYSVSLCFSYSDKlk-------------------------dAFFGYVYNLatGDEYYADs- 130 Archaeoglobus fu...
1VDW_A       79 YTVVVDPLDGSYNFINGiPFFAVSVAIFHEKD----------------------------PIYAFIYEPivERLYEGIpg 130 Pyrococcus horik...
Q58327       82 YIFILDPIDGTYNALKSiPIYSTSIAVAKIKGedkklireninnidwiksfiankytindLYVGIVKNLatGDLYYAIkg 161 Methanocaldococc...
NP_618233    84 FSVVLDPLDGTYNASVGiPFYSVSIAFASHDLs--------------------------dLRFGYVSNLalREEYYAEag 137 Methanosarcina a...
O26957       89 IIFVVDPLDGTSNAIRNiPFYGISVAVAERHPdgaap-------------------tlnnVLMGFVKNFatGDLYWAIkg 149 Methanothermobac...
AAM48105     79 YTVIVDPLDGSYNFIAGiPFFALSLAVFKKDK----------------------------PIYAIIYEPmtERFFEGIpg 130 Pyrococcus furiosus
ZP_00148789  84 FTIILDPIDGTYNVANDiPFYGISIAIGTPDLs--------------------------sTYFGYVRNLanGDTFYAEsg 137 Methanococcoides...
NP_988609    80 YVIVLDPVDGTYNSLKDiPFYSAAVAIGRIDKfadnleel------------innlkmkdLEVGVVRNIatGDTYYAEkg 147 Methanococcus ma...
Feature 1                                                                                       
1DK4_A      128 kGAYLn--GRKIKVKDFnp---nNIVISYYpskkidl-------eklrnkvKRVRIFGAFGLEMCYVAKGTLDAVFDVRp 195 Methanocaldococc...
1G0H_A      128 kGAYLn--GRKIKVKDFnp---nNIVISYYpskkidl-------eklrnkvKRVRIFGAFGLEMCYVAKGTLDAVFDVRp 195 Methanocaldococc...
1LBV_A      131 sGAYRn--GERIEVSDAee---lYCNAIIYypdr-------------kfpfKRMRIFGSAATELCFFADGSFDCFLDIRp 192 Archaeoglobus fu...
1VDW_A      131 kGSYLn--GEKIKVRELae---kPSISFYTkgkgtk----------iidkvKRTRTLGAIALELAYLARGALDAVVDIRn 195 Pyrococcus horik...
Q58327      162 eGSFLekdGEKIKIETKnikdlkEASVGLFvyglsndll----eflkerkvRRVRLFGSMALEMCYVVSGALDAYINVNe 237 Methanocaldococc...
NP_618233   138 kGAYLn--GNRIKTSVNsd--lkSLCVSVYgyrqnver-----trriysnvRRVRLFGSVALELCYAASGRLDAFVDVRk 208 Methanosarcina a...
O26957      150 qGAFLn--EKAISSSSQss--ldRTSLGAFiygtrfrr-----vdsicrviRRMRILGSVALELAYVASGSYDAFMDLRe 220 Methanothermobac...
AAM48105    131 eGAFLn--GKRIKVRKTpd---eKPSISFYsrgkgh---------eivkhvKRTRTLGAIALELAYLAMGALDGVVDVRk 196 Pyrococcus furiosus
ZP_00148789 138 kGAYFn--DKRISHSKCss--lnDFCVSLYgyrknver-----tvdlcknvRRIRIFGSVSLELCYVASGRLDAFVDVRg 208 Methanococcoides...
NP_988609   148 kGAHFl--RKGEKKSISis--nsSNLKDSSiglfahdisidtlkfikdrrfRRIRLFGSIALEMCYVAKGALDAFINVNe 223 Methanococcus ma...
Feature 1           #  #                                                    
1DK4_A      196 --kVRAVDIASSYIICKEaGALITDEngdelkf-dlnatdRLNIIVAnskemLDIILDLL 252 Methanocaldococcus jannaschii
1G0H_A      196 --kVRAVDIASSYIICKEaGALITDEngdelkf-dlnatdRLNIIVAnskemLDIILDLL 252 Methanocaldococcus jannaschii
1LBV_A      193 gkmLRIYDAAAGVFIAEKaGGKVTELdgeslgnkkfdmqeRLNIVAAne-klHPKLLELI 251 Archaeoglobus fulgidus
1VDW_A      196 --yLRPTDIAAGVVIAREaGAIVKDLdgkdvei-tfsateKVNIIAAn----NEELLETI 248 Pyrococcus horikoshii
Q58327      238 --nSRLCDIAGAYVICREgNAIVTNKngkplnm-klhlmeRTSLIVSnk-ylHKKLIALF 293 Methanocaldococcus jannaschii
NP_618233   209 --aLRVTDVAAGQLILEEaGGLVTDGygktlrl-pdnvtaRVEMVASng-rvHKKLLSLL 264 Methanosarcina acetivorans C2A
O26957      221 --nLRIVDIAASKLIVEEaGGVVTNErggeidg-llnvkaRTSLVAAgnlelHEKIMQTL 277 Methanothermobacter thermautotrophic...
AAM48105    197 --yVRPTDIAAGTIIAKEaGALIKDSagkdidi-sfnatdRLDVIAVnseelLKTILSLL 253 Pyrococcus furiosus
ZP_00148789 209 --sLRLVDVAAGKLIIEEsGGIVTDGdgntlkl-kdsvinPVYMVASng-caHSDILKLV 264 Methanococcoides burtonii DSM 6242
NP_988609   224 --tTRLCDIAAGYVIIKEaGGIVTDKngqevnl-dldvnsKVSVICSne-mlHKKLVGIF 279 Methanococcus maripaludis S2

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