1FTA,1DK4,1INP,1QGX,2HHM


Conserved Protein Domain Family
IMPase_like

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cd01637: IMPase_like 
Click on image for an interactive view with Cn3D
Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-bisphosphate, inositol poly- and monophosphates, PAP and PAPS, sedoheptulose-1,7-bisphosphate and probably others.
Statistics
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PSSM-Id: 238815
Aligned: 44 rows
Threshold Bit Score: 103.548
Threshold Setting Gi: 1311146
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                ##     
1FTA_A       34 LNSLCTAVKAISSAVrkagiahlygiagstnvtgdQVKKLDVLSNDLVMNMLkssf----------atcVLVSEEdkhai 103 human
1DK4_A        4 DEIGKNIAKEIEKEIlpyfgrkdksyvvgtspsgdETEIFDKISEDIALKYLksl------------nvNIVSEElgvid 71  Methanocaldococc...
2HHM_A        8 MDYAVTLARQAGEVVceaiknemn--vmlksspvdLVTATDQKVEKMLISSIkeky----------pshSFIGEEsvaag 75  human
NP_212658     2 DWDFEKIIFLLNESTrlal-------------sgcAKLILDFKSDGSIVTQVdkqieqflfkeikkpgnFVLGEEtisty 68  Borrelia burgdor...
NP_359960     5 TNLLINALRKAVKFLhrdfleleml-qkhsvrneeFCKRSYLKLKTLLCEELqky-----------tqyLFFPEDkfdln 72  Rickettsia conor...
NP_376435     2 REVLVKITKEIISFLyeekdkqgid-kiigkhgndVTRVIDKKSEELIFDRLnhsg----------ykfMFVSEEagvvn 70  Sulfolobus tokod...
NP_436690    14 AELCREVIRSAGALIlkgfqgearq-nismkgpqdFLTEVDEASEAHIREALaahf----------pgdGFFGEEgggai 82  Sinorhizobium me...
NP_600029    37 EHLAQALVYNAGRLAwrmrengvd--tdyktsvsdVVTDADRAAEAFVAGVLealr----------pedGVLGEEgadra 104 Corynebacterium ...
ZP_00206943   9 LTLALEVAAEAGRLAldffarreslaveakaspqdIVSRADREVETLIRARIaarf----------pddGVLGEEhgaee 78  Rhodobacter spha...
ZP_00210659   9 TNIMLKSVRQSSRALirdfseirym-qssytaasnFTRSAYLRSKKIITDGLynyr----------qdyGVVFDDtrdvs 77  Ehrlichia canis ...
Feature 1                        ######                                                         
1FTA_A      104 ive---pekrgkyvVCFDPLDGSsnid-clvsVGTIFGIYrkkstdepsekdalqpgrnlvAAGYALygs-------atM 172 human
1DK4_A       72 n--------ssewtVVIDPIDGSfnfingipfFAFCFGVFknn---------------epyYGLTYEfl--------tkS 120 Methanocaldococc...
2HHM_A       76 eks----iltdnptWIIDPIDGTtnfvhrfpfVAVSIGFAvnk---------------kieFGVVYScv--------egK 128 human
NP_212658    69 keeyikdalisestFIIDPIDGTssfaaglpsYGISLAYAsgg---------------kiiEGAISLplsgeffitskdN 133 Borrelia burgdor...
NP_359960    73 n--------nyesvFLINPIDSPnnfarsipfFAISVTYLkrnqe-----------vliptSTVIYFpa--------lnE 125 Rickettsia conor...
NP_376435    71 k-------enyeyiAIIDPLDGStnylngipwSSVSIAVYrrgekd----------ilssfTGVVGNif--------tkK 125 Sulfolobus tokod...
NP_436690    83 ----------sdrvWVVDPIDGTanfargiphFCISIAFVqsg---------------steIAAIYNpa--------ldE 129 Sinorhizobium me...
NP_600029   105 s--------ksgktWVIDPVDGTynftqgsdyWCSALALVegdpsa----------psrvlFGAVHRpa--------mgY 158 Corynebacterium ...
ZP_00206943  79 g--------rsgftWVIDPIDGTapflaglphWCVVLALQeeg---------------rtvAGVIEHpl--------arE 127 Rhodobacter spha...
ZP_00210659  78 d--------vgenfWFVNPIDSKtnfisylpyFATLIAFFrqg---------------epvAAIIDApi--------lkE 126 Ehrlichia canis ...
Feature 1                                                                                       
1FTA_A      173 LVLAMd-cGVNcfmldpaigefilvdkdvkikkkgKIYSlneayakdfdpavte-yiqrkkfppdnsapyGARYVgsmvA 250 human
1DK4_A      121 FYEAYkgkGAYlngrkik----------vkdfnpnNIVIsyypskkid-------------leklrnkvkRVRIFgafgL 177 Methanocaldococc...
2HHM_A      129 MYTARkgkGAFcngqklqv---------sqqeditKSLLvtelgssrtpetvrm--vlsnmeklfcipvhGIRSVgtaaV 197 human
NP_212658   134 VFYAKkniGSYpl--------------------kkDFNKfifdnskcynihsllavsrsiirlfnldissHIHINgscvY 193 Borrelia burgdor...
NP_359960   126 IYYAEkgkGAWieknnlnsnyq--glrlrvsdnadLRNClaiiegvnh-------------ndleeievdNIRSFgslcY 190 Rickettsia conor...
NP_376435   126 IYSYDe-nFSYideekis-----------tphppdRLLIlayfsrsrllsv--------knfldslnadyKIRSLgsasL 185 Sulfolobus tokod...
NP_436690   130 LYFARrgaGATrngvpirv---------aqtirfdAASLemgwsmrvpntay------lgvmeallgmgaNVRRAgsgaL 194 Sinorhizobium me...
NP_600029   159 TWFGGpgiRTTldgkeldl---------lvdaplnQISLatyihpsriaepd-----iqkawmsvathpaTLRMFgagsI 224 Corynebacterium ...
ZP_00206943 128 TFSAQrgqGAFlngerlra---------redltigSCNValgashrtspdfa------salvrelmrrggMFYRNgsgaI 192 Rhodobacter spha...
ZP_00210659 127 TFYVErgvGAFsenvqsryik----lhvgnkqtvsRAVIdfvithlsidm----------idsqlnsqavIIRAMgsmaL 192 Ehrlichia canis ...
Feature 1                                    ##                                                 
1FTA_A      251 DVHRTLVy-GGIFLYpankkspngklrllYECNPMAYVMEKa-GGMATTGkeavldvi---------------------p 307 human
1DK4_A      178 EMCYVAKgtLDAVFDvrpk-------vraVDIASSYIICKEa-GALITDEngdelkfd---------------------- 227 Methanocaldococc...
2HHM_A      198 NMCLVATggADAYYEmgi---------hcWDVAGAGIIVTEa-GGVLMDVtggpf------------------------- 242 human
NP_212658   194 SFAKLFTgsYKAYFSfv----------glWDIAACLAIGNKl-GMVGEFYcgnkmtldildsmyilepnnhkrwslkdff 262 Borrelia burgdor...
NP_359960   191 GATLVASgkADLICLsll---------nfTLYYAFELFIKEa-GGIIIDSsdkf-------------------------- 234 Rickettsia conor...
NP_376435   186 DMILVCTgkASIYFDvrgk-------lrnVDVAASSNFCKRl-GIIPRNSrleeirvgi--------------------e 237 Sulfolobus tokod...
NP_436690   195 ALAYVADgrLDGYIElhm---------nsWDCLAGLLLVSEa-GGVVCPYleigsldaggp---------------alav 249 Sinorhizobium me...
NP_600029   225 DLANIADgsIGAWVQhsv---------adWDWLPGRALIEGv-GGACIKVtaggve------------------------ 270 Corynebacterium ...
ZP_00206943 193 MLASVAAgrLGGYYEphm---------npWDCLAAMLMVEEa-GGRTAPFpeda-------------------------- 236 Rhodobacter spha...
ZP_00210659 193 GFAYLCSasYDALIYsnl---------nkYQAAVGKLFVEEskGKIVCDNelf--------------------------- 236 Ehrlichia canis ...
Feature 1                   
1FTA_A      308 tdihqraPIILG 319 human
1DK4_A      228 lnatdrlNIIVA 239 Methanocaldococcus jannaschii
2HHM_A      243 --dlmsrRVIAA 252 human
NP_212658   263 iysdnksTIDII 274 Borrelia burgdorferi B31
NP_359960   235 ---lysnRYIAK 243 Rickettsia conorii str. Malish 7
NP_376435   238 kveqiqeIILSS 249 Sulfolobus tokodaii str. 7
NP_436690   250 apglasdTSRAS 261 Sinorhizobium meliloti 1021
NP_600029   271 --wsvagNAEAV 280 Corynebacterium glutamicum ATCC 13032
ZP_00206943 237 ---aggmVLVAA 245 Rhodobacter sphaeroides
ZP_00210659 237 ----iasNFALC 244 Ehrlichia canis str. Jake

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