Conserved Protein Domain Family
Arch_FBPase_2

?
cd01642: Arch_FBPase_2 
Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1,6-bisphosphatase catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway.
Statistics
?
PSSM-Id: 238820
Aligned: 8 rows
Threshold Bit Score: 243.51
Threshold Setting Gi: 20140351
Created: 5-Aug-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:by similarity to the other predominantly archaeal family in this hierarchy

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                       ##            
NP_376435   1 MREVLVKITKEIISFLYEekdkqgIDKIIgk--hGNDVTRVIDKKSEELIFDRLnhs-gyKFMFVSEEAGVVnke-nyeY 76  Sulfolobus tokodai...
NP_343774   1 MINLLNKVAIDATRYLNEiknekdLDKVIgf--hAGDTTRVIDKKSEEYIFQLLndt-glKFKFVSEESGVRvpsnsydY 77  Sulfolobus solfata...
NP_281339   4 FLDACLNANLQIRKYLNNip--qnDLKLCsklgyDKNQGYELDLKCEQIFIKYLs----cFGQIFSEESGLIgka--spK 75  Campylobacter jeju...
NP_560458   1 MLGVLEAIAARASQLIWEsfr-lgLGAGIvs-rkEDDVSREVDLAAEELVYKMLresfkeGGVLYAEEGGEYrwg-dgrY 77  Pyrobaculum aeroph...
Q9YAZ7      8 LRRVSVKVSSETAGLLRDla---cSEDLGr---vVSGETTVADKRAEDYILDLLrre-lgQVQVISEEAGGVasktsdaP 80  Aeropyrum pernix
NP_906421   4 FVGSVLEATKEAIRALNPqns-tiYESLMvg--aGGDVSLKADLMCEEILSARLr----hFGHIHSEESGLIege--sqD 74  Wolinella succinog...
NP_860770   4 FLHKAILATHKIILALQEknq-alYVTHNfg--aGGDKSIGADLLSEKIYTEHLi----sLANIDSEESGFInga--gnD 74  Helicobacter hepat...
NP_614025   1 MRETVEKIVKERVLPEVSkvr-rgWVEVGrg--aDGTPTMRVDEVAEREFLRGLeee-gvDARVISEESGEMrvgeapeV 76  Methanopyrus kandl...
Feature 1         #### #                                                                      
NP_376435  77 IAIIDPLDGSTNYLNGIPWSSVSIAVYRRge---------kdILSSFTGVVGNif---------tkKIYSYDENFSYIDe 138 Sulfolobus tokodai...
NP_343774  78 VALIDPLDGSNNFVLGVPWYSISVAIYGKss---------nsLLDSLGGFVSHis---------idKIYSYDTSSAYLNg 139 Sulfolobus solfata...
NP_281339  76 QMILDPLDGSSNFVSKIPFYGTSIALMEKdq----------aKSAFVCNLVSQei----------fAFNNKQAFKSNLSd 135 Campylobacter jeju...
NP_560458  78 IFVLDPLDGSLNYAVGIPFFSVSLAAGRY-------------KDGTLSDLEYA-------------VVAIPPTGEVYTAg 131 Pyrobaculum aeroph...
Q9YAZ7     81 IALVDPLDGSTNYLSCITWCSVSVAFADPrsgeilagsvapvYAGMPVSFARGkgcy-----hgglKVEDPSIRGSIISv 155 Aeropyrum pernix
NP_906421  75 IIYLDPLDGSTNLSSLIPYYGTSVALCDPeg---------rtKAAAVINFCSGetfiktdafalhgSIWQPIDTFVPIRp 145 Wolinella succinog...
NP_860770  75 CIVLDPLDGSDNFLSHIPYYGSSLALCDAnv---------kvKEAVIFNFCTKeg---------faHLGDKPFRFYIESy 136 Helicobacter hepat...
NP_614025  77 TLVLDPLDGSHNASRGLPFYCVSVGIADP-------------EAETLDDVEEG-------------LVVSELLTFGPGDv 130 Methanopyrus kandl...
Feature 1                                                                              #  #   
NP_376435 139 ekist------phppdRLLILAYFSRSRllsvknfldslnadYKIRSLGSASLDMILVCTGKASIYFDvrgkLRNVDVAA 212 Sulfolobus tokodai...
NP_343774 140 nplka-----eiignsPSNVVITYFDERgidkilkvlsalkgYKIRSFGSASLDMILTCMGKAKLYFDirgkLRNVDIAA 214 Sulfolobus solfata...
NP_281339 136 pkysp------ltpnlFSKIGIVEKISLypelld--fltknqLKFRSLGATALSLAYASYFSFVLILGk---TRIFDTAA 204 Campylobacter jeju...
NP_560458 132 pglgarkngrplkravKSNIVFIAASNNfpektce-vvkrfgLKGRSLGSSAAELVYTVEGIARGFLDlrgkLRVLDAAG 210 Pyrobaculum aeroph...
Q9YAZ7    156 yvdep-----gaiesvAGAIGRLKGVRRd-------------FKVRSLGSAALELAYTAIGYIAVFADlrarLRNIDVAA 217 Aeropyrum pernix
NP_906421 146 l-------------ehASKIGIFEGSHRnapwvl--glhqkgLKFRSPGAIALSMAYAHNVSFVLFDGe---IREYDTKA 207 Wolinella succinog...
NP_860770 137 mhqgels-fmplvstpLGKCGIFEKAYCnpsfat--llyenhLKFRSLGASALSMAKSYEANFMLFLGn---IRKFDSKA 210 Helicobacter hepat...
NP_614025 131 eekp--------vverPLVSAYYYGSDRmpvef-----srgrFKLRCLGSVALELALVGKGALDGFVDvrgsLRPTDVAG 197 Methanopyrus kandl...
Feature 1                                                     
NP_376435 213 SSNFCKR----------LGIIPRNSrleeirv-giekveqIQEIILSS 249 Sulfolobus tokodaii str. 7
NP_343774 215 SANFCKR----------LNSIPSTLngkeiss-giddiykIDEIIVSR 251 Sulfolobus solfataricus P2
NP_281339 205 ALAIHQNl--------yIEKNENFLllsq--------dkkIFDIILEF 236 Campylobacter jejuni subsp. jejuni NCTC 11168
NP_560458 211 ALTVGKYvegf---kyvVLGDPSPHsrvs--------ivaGDEEFVNA 247 Pyrobaculum aerophilum str. IM2
Q9YAZ7    218 AVGAVREcggv---vtdAHGQPLRIgvwrver-vgsvvasLDEALARI 261 Aeropyrum pernix
NP_906421 208 GLFLCSDl--------hIHHDERALlisr--------dpiIFENLLEL 239 Wolinella succinogenes DSM 1740
NP_860770 211 GLFLCDK----------LHHLRTNNftlis------kdkhIFDIIHKF 242 Helicobacter hepaticus ATCC 51449
NP_614025 198 AFGAARGelafifarngRELDPSEIplrpdfrfelatarsEDEARELF 245 Methanopyrus kandleri AV19

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap