Conserved Protein Domain Family
Ketohexokinase

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cd01939: Ketohexokinase 
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes where it is believed to function as a dimer and requires K(+) and ATP to be active. In humans, hepatic KHK deficiency causes fructosuria, a benign inborn error of metabolism.
Statistics
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PSSM-Id: 238914
View PSSM: cd01939
Aligned: 12 rows
Threshold Bit Score: 260.417
Threshold Setting Gi: 32404862
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
substrateATP binding
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other members of the family
  • Citation:PMID 9519409

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #                     
NP_649180   32 HVLAVGSCTLDmitivdlplf---------------pgqvqrtteGSWRRGGp---AANICTVWRRLGl----------- 82   fruit fly
P50053       5 QILCVGLVVLDvislvdkypk---------------edseirclsQRWQRGGn---ASNSCTVLSLLGa----------- 55   human
AAL49031     6 SVLCVGCTVIDfvtingsypm---------------edtdrrcldGFWQRGGn---ASNVSTVLRVLGc----------- 56   fruit fly
AAL89841    16 TVLCIGTTTIDfvstikrfpe---------------enshqkvigGYWIRGGk---ASNNCTVLANLGv----------- 66   fruit fly
EAA57180    45 AKLWHGHSVPHfpqeds----------------------klratnVQVRRGGn---GANTLEVLQQLLprcgd------- 92   Magnaporthe gris...
NP_648465   12 AVLCVGCTEVDyvttmdkvdf---------------qcdrcstqnGMLQRSGr---SSNVSTALRLLGa----------- 62   fruit fly
CAF94177     6 KILCVGLVCLDiinvvdkype---------------edtdsrclsQRWQRGGn---ASNSCTVLSLLGa----------- 56   Tetraodon nigrov...
AAH80009     5 GILCIGLVCLDiisvvekype---------------edsdsrclsQRWQRGGn---ASNSCTVLALLGa----------- 55   African clawed frog
XP_323044   64 RLACSVPQFPDedskl-------------------------rataLQVRRGGn---CPNTAEVLQQLLl----------- 104  Neurospora crassa
XP_396876   22 KILCVGVSCLDivqtckqypv---------------edsdqrsieCRWQRGGn---ASNSCTVLSLLGs----------- 72   honey bee
AAM11001    35 HVLAVGSCTLDmitivdlplf---------------pgqvqrtteGSWRRGGp---AANICTVWRRLGl----------- 85   fruit fly
EAA65750   305 MKDWIQERYPDdrqlsydalreivraswdavptdflkgligintnGRIQRSHilstSSNLKNLDDPLTtrsehpiilerm 384  Aspergillus nidu...
Feature 1                                                                                      
NP_649180   83 -------eCEFLGVLSrvra------------------------------------------------------------ 95   fruit fly
P50053      56 -------pCAFMGSMApghv------------------------------------------------------------ 68   human
AAL49031    57 -------kVDFFGMLSrsdg------------------------------------------------------------ 69   fruit fly
AAL89841    67 -------kVEFLGMLSswsv------------------------------------------------------------ 79   fruit fly
EAA57180    93 ---qedqrRPSLHLMTplpdle---------------------------------------------------------s 112  Magnaporthe gris...
NP_648465   63 -------nVELFGVLTrnpt------------------------------------------------------------ 75   fruit fly
CAF94177    57 -------pSAFMGSLAagpv------------------------------------------------------------ 69   Tetraodon nigrov...
AAH80009    56 -------pCAFMGSLApghm------------------------------------------------------------ 68   African clawed frog
XP_323044  105 -------sGGGLGFSStqnqpdsaagvvavtpppsqeqqqqqqqqlklhlvsilpdvgspairkilssfatppapqpsps 177  Neurospora crassa
XP_396876   73 -------sCEFFGTLSaeeh------------------------------------------------------------ 85   honey bee
AAM11001    86 -------eCEFLGVLSrvra------------------------------------------------------------ 98   fruit fly
EAA65750   385 tsyeqrayCGGVGLVPqpsfgqepplkli-------------------------------------------avlpaqts 421  Aspergillus nidu...
Feature 1                                                                                      
NP_649180   96 --fesLLNGFQSqgidish--------cpltnhrPAHRSIIVQrnvdtRTMLEFANANQELTYQQFVGavd--yqkYSWI 163  fruit fly
P50053      69 --adfVLDDLRRysvdlryt------vfqttgsvPIATVIINEas-gsRTILYYDRSLPDVSATDFEKvdl---tqFKWI 136  human
AAL49031    70 --frvLLDDLSKreigtndc-------pftdrdpPFSSVILAQds-gtRTIIHCNKDYPQTTYEDFSKinl---sqYGWV 136  fruit fly
AAL89841    80 --fqvLVDDLKSrgiiidnc-------ptcdqgaPFSSVILTKat-ktRNIVYCNNNFPYVSIDDFRKlnl---nqYGWI 146  fruit fly
EAA57180   113 petaqVVDSFGIdspidlslc-----lhrkgiqkAASSYIVRSna-tgSRTIVNHNPLSEMEVDEFSQ--------AAET 178  Magnaporthe gris...
NP_648465   76 --yrmILDDLEQrgidishc-------tftdaspPFSTIVQDRwt-rrCTVVYCDKSFPYVTAADFRKldl---dqYGWV 142  fruit fly
CAF94177    70 --anfIMDDLLAravdasav------vwqvkgetPCACCVVCPtt-gsRTVVLFDTNLPDVTAENFSQvdl---rqFKWI 137  Tetraodon nigrov...
AAH80009    69 --adfIVSDFQRrgigtsnv------swqsrgdtPCACCLINTss-gsRTVTLYDTNLPDVTEEDFQRvel---tqYKWI 136  African clawed frog
XP_323044  178 ydsesLFESVTSaasatatsvdfshclyrkghdeAASSYIIRSga-tgSRTIVNYNDLPEMTTDEFMKi------aDGFV 250  Neurospora crassa
XP_396876   86 --lnfFQNDMQKynidfshc------pmikkigcPISTIILSLss-gsRTIVHHNPNLPELTLKNFEQlhl---edYSWI 153  honey bee
AAM11001    99 --fesLLNGFQSqgidish--------cpltnhrPAHRSIIVQrnvdtRTMLEFANANQELTYQQFVGavd--yqkYSWI 166  fruit fly
EAA65750   422 vaskqIRDAFEPqvslnnci-------yrqefkePASSYIIKSqa-sgSRTIVNYNELPEMKLEEFIQiadklgteARWF 493  Aspergillus nidu...
Feature 1                                                                                      
NP_649180  164 HFECRNp-------vEMLRMVLAVIQFNercpe---------sritLSVDLDNLRpatml---masmvDYVFARKtmmrt 224  fruit fly
P50053     137 HIEGRNa-------sEQVKMLQRIDAHNtrqp----------peqkIRVSVEVEKpreelf-qlfgygDVVFVSKdvakh 198  human
AAL49031   137 HFEARNt-------pHTLKMMQSIREYNqrtg----------qgiiISLDFETRYeqnqe---lcapcDFVVFSKelagq 196  fruit fly
AAL89841   147 HIRALYf-------dKSLPMVKDIEAYNanr------------kekIVLSMEFDNnlddmw-plmdycDYAVFSKklaqp 206  fruit fly
EAA57180   179 WFSRMQa--------EPSRTWWHFEAKG------------------YRSPEECLRr------------EAPSTAS----- 215  Magnaporthe gris...
NP_648465  143 NFEARSp-------rETCDMIRLILDHNngrd----------erdrIVVSLQIFNsfeqvv-hliamcDYVFVTKyiaes 204  fruit fly
CAF94177   138 HWEGRNa-------eEQLKMIQRVEEYNtsap----------lpqsITVSVEIEKtreply-rlfphaDVVFVSKdvarh 199  Tetraodon nigrov...
AAH80009   137 HWEGRNa-------dEQVKMIRRVEEHNrgrg----------aeepITISVEIEKereely-qlfaygDVVFVSKdvarh 198  African clawed frog
XP_323044  251 SLQHDHnvdassrgfIGEDCWWHFEVLPg-----------------STISVEVEKpgreglaelaaesDVVFYSKswaes 313  Neurospora crassa
XP_396876  154 HFEGRNl-------nEVLSMMQCVENYNnmlnysqdnkeidtnqapITISVELETpkqell-dllpyvDLVFIAKdfaqs 225  honey bee
AAM11001   167 HFECRNp-------vEMLRMVLAVIQFNercp-----------esrITLSVDLDNlrpatm-lmasmvDYVFALLrtlgl 227  fruit fly
EAA65750   494 HFEGRIp-------dVTLSCMRHIREHYp----------------sIKISVEVEKpgreglqelaqeaDVVFYSKswaqa 550  Aspergillus nidu...
Feature 1                                                                                      
NP_649180  225 ycfmngrevvwairnemrrartqweksqpkkmpylppdppdehsngycpgplnnqpvVIYNNYm-eGASCLMa------- 296  fruit fly
P50053     199 lgfqsaeea-----------------------------------lrglygrvrkgavLVCAWAe-eGADALGp------- 235  human
AAL49031   197 lgwktprqsc---------------------------------eelaskipeggpkpVFICPWgsaGAGAMDa------- 236  fruit fly
AAL89841   207 ngwvsledacmq-----------------------------lderlrmrwglnlkrpYVVVLWgdqGAGILDl------- 250  fruit fly
EAA57180   216 ---------------------------------------------------------HVFVTWgghGASAMAik------ 232  Magnaporthe gris...
NP_648465  205 rgwkspleaceg----------------------------vnallrmprnirirrpcIIVPWSs-lGAGCMTt------- 248  fruit fly
CAF94177   200 fgfptaea------------------------------------alrgfyprvkqgaVLICAWaeqGADALGp------- 236  Tetraodon nigrov...
AAH80009   199 fgfnsare------------------------------------avcglyprvrkgaYLVCAWaeqGADALGp------- 235  African clawed frog
XP_323044  314 rgytnpea------------------------------------clrgelpnckkasLMLCTWgcqGAGALFpspagtgg 357  Neurospora crassa
XP_396876  226 rgyenmse------------------------------------tlknigeeaksgaTLICAWgdrGAMARTp------- 262  honey bee
AAM11001   228 rpkkvp----------------------------------------vqetsmavlpaAHSYAHs-hGSLYRLa------- 259  fruit fly
EAA65750   551 ngyksake------------------------------------ciekqsfqlgkatLLCCTWgqdGAAALEpr------ 588  Aspergillus nidu...
Feature 1                                        #  #                                          
NP_649180  297 ----------dDTYFKvgsq-----ippkLVDVVAVNDTFSAAVIYALIKvkm--------rlrDAIEYGTRASSLKLTG 353  fruit fly
P50053     236 ----------dGKLLHsdaf-----ppprVVDTLGAGDTFNASVIFSLSQgrs---------vqEALRFGCQVAGKKCGL 291  human
AAL49031   237 ----------nGNYYEmssy-----kqdkVVDTLGAGDSFMAGFIYATLKarr--------slaEAVDFANRVASHKITG 293  fruit fly
AAL89841   251 ----------nGNFTHvkph-----kpkrIVDALGAGDTFVGAFIYALYIrer--------svsVAVDFGNRMASYKCTK 307  fruit fly
EAA57180   233 ---------gqDEYHHcdvhvdngnddirVVDTVGAGDTFIAGILFGFAChpdd------wdlpRKLRFAVRLATQKVQM 297  Magnaporthe gris...
NP_648465  249 ----------eGEYFEvpah-----kpkkIIDRVGDSDCFTAGFIYAAFVrqr--------rlaEAVDFANAVASYKLGY 305  fruit fly
CAF94177   237 ----------dGVIVHsdaf-----ppesLVDTLGAGDTFNAAVIYTLSNggs---------lqDALTFGCRVAGCKCGF 292  Tetraodon nigrov...
AAH80009   236 ----------dGSVVHsgaf-----spenIVDTLGAGDTFNASVIYSLSKgqs---------mqEALTFGCQMAGKKCGV 291  African clawed frog
XP_323044  358 gnneqtaevaePDYLHcstaevfetqiitVVDIRGSQKANDINTANKVNPspdhstigagdtfiAGIMYGLLMASPSATA 437  Neurospora crassa
XP_396876  263 ----------dNIIVQspaf-----ppqkVIDTLGAGDTFNAAVLHFLNKak-----------lEFIRKRNLQTNEATSV 316  honey bee
AAM11001   260 -----------GCHYHfi----------rLAGIVGASAIFMGAYCKYVLK--------------DVSDPKEQVDSQAFAD 304  fruit fly
EAA65750   589 ----------vGSAVQspayt---pkgfqVVDTIGAGDTFIAGMLYGLTVkgdt------wdlsQKLSIANRLAGTKVAQ 649  Aspergillus nidu...
Feature 1          
NP_649180  354 NGFD 357  fruit fly
P50053     292 QGFD 295  human
AAL49031   294 FGYE 297  fruit fly
AAL89841   308 NGYD 311  fruit fly
EAA57180   298 DGFG 301  Magnaporthe grisea 70-15
NP_648465  306 VGFD 309  fruit fly
CAF94177   293 HGYD 296  Tetraodon nigroviridis
AAH80009   292 QGFD 295  African clawed frog
XP_323044  438 TATA 441  Neurospora crassa
XP_396876  317 LHTD 320  honey bee
AAM11001   305 VANR 308  fruit fly
EAA65750   650 EGFD 653  Aspergillus nidulans FGSC A4

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