1TOT


Conserved Protein Domain Family
ZZ_CBP
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cd02337: ZZ_CBP 
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Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that provides binding sites for transcriptional coactivators, the role of the ZZ domain in CBP/p300 is unclear.
Links
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Statistics
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PSSM-Id: 239077
Aligned: 11 rows
Threshold Bit Score: 68.3587
Created: 29-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
  • Structure:1TOT: ZZ domain binds zinc
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #           #  #     #  #        # #     
1TOT_A       7 YTCNECKh-HVe-TRWHCTVCEDYDLCINCYNT---KSHTHKMVKW 47   house mouse
XP_148699 1687 YTCNECKh-HVe-TRWHCTVCEDYDLCINCYNT---KSHTRNPGVS 1727 house mouse
P34545    1497 YTCNKCS--SP--AVWHCQSCDDFDLCDGCKPT---TQHPHEMEKI 1535 nematode
CAF95299  1728 YTCNECKh-HVe-TRYHCTVCEDYDLCITCYNT---KGHVHKMDKL 1768 Tetraodon nigroviridis
XP_416238 2396 YTCNECKh-HVe-TRWHCTVCEDYDLCITCYNT---KNHDHKMEKL 2436 chicken
AAH86282  1696 YTCNECKh-HVe-TRWHCTVCEDYDLCVNCYSA---KNHEHKMVKW 1736 African clawed frog
T13828    2333 YTCNHCKt-AVe-TRYHCTVCDDFDLCIVCKEK---VGHQHKMEKL 2373 fruit fly
AAL54859  1614 YTCNSCKa-AVe-TRYHCSTCDDFDLCVPCYNK---EGHHHKMTKL 1654 California sea hare
Q09472    1668 YTCNECKh-HVe-TRWHCTVCEDYDLCITCYNT---KNHDHKMEKL 1708 human
EAL41310  1331 YTCNNCKn-HVe-TRYHCTVCDDFDLCITCKEK---VGHQHKMDKL 1371 Anopheles gambiae str. PEST
AAC17068  1378 TTCNACHldIEtgQGWRCEVCPDYDVCNACFSRdggVNHPHKLTNH 1423 thale cress

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