1P0N,1VCF,1VCG


Conserved Protein Domain Family
IDI-2_FMN

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cd02811: IDI-2_FMN 
Click on image for an interactive view with Cn3D
Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal, FMN and NADPH. IDI-2 catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the mevalonate pathway.
Statistics
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PSSM-Id: 239205
Aligned: 73 rows
Threshold Bit Score: 353.341
Created: 26-May-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:1P0N; Bacillus subtilis IDI-2 binds FMN
    View structure with Cn3D
  • Comment:One FMN molecule is bound per monomer

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                   ####                
1P0N_A        6 RKRQHINHALSigqk--retGLDDITFVHVSLPDLALeQVDISTKIGELSSs-sPIFINAMTGGggklTYEINKSLARAA 82  Bacillus subtilis
Q92BX2       12 RKDEHVALGVKqnen-lapsSLEDIQLIGTSIPRYNVkDIDLTTTFLGATVp-fPFYINAMTGGsr-hTKRINAELAEIA 88  Listeria innocua
Q88WB6        9 RKDEHVSLAEKyfhg-eqanAFDQVRIRHDALPETAVaDVDLATTVGQWHWd-sPLYIEAMTGGsq-rTGEINARLGRIA 85  Lactobacillus pl...
Q8DUI9        4 RKDDHIKYALDyrs---pynSFDDIELIHHSLPDYDLaEIDLSTHFAGQDFd-fPFYINAMTGGsq-kGKEVNEKLAQVA 78  Streptococcus mu...
YP_194040     7 RKEEHLKLAQMffnk-ekynSFDQLHLLRPALPETKVdINVLATKMFNKNVs-aPFFINAMTGGsd-kSKIINQALGRIA 83  Lactobacillus ac...
ZP_00875670  11 RKDQHVGLANQqysa-tpakDFTETLFVHHSLPQTKVdEVDISTSVAGLDFa-fPFFINAMTGGsk-kTREINRLLGIMG 87  Streptococcus su...
YP_395516    12 RKDEHVFLAEKfhqd-drqnDFDGLRFIHQSLPELAIaDVDISTQFAGTTWq-sPFYINGMTGGsq-qTKKLNAQLAQVA 88  Lactobacillus sa...
YP_535575     7 RKNEHLSLAEKffkt-qssnQLDEVQLIYSNLPELNLsDIDIRSTLVGKDIp-vPFFINAITGGss-qTDDINYKLSTVA 83  Lactobacillus sa...
ZP_01273286   9 RKNEHLSLAAKyydqvhqhhYFDQVRLIHDSLPEMTTdDVDLHVQLADNLEiecPFYIEAMTGGsd-qALKINQQLAQLA 87  Lactobacillus re...
YP_795034     9 RKDEHLSLAEKfytp-tatsQFDQLRFVHQSLPEISLtDVDFSTQLGPLSLk-vPLMIEAMTGGsp-rTGVVNAQLGRIA 85  Lactobacillus br...
Feature 1                 #                            #                        #               
1P0N_A       83 SQAGIPLAVGSQMSALkdpsERLSYEIVRKEnpnglIFANLGSeataAQAKEAVEMIGANALQIHLNVIQEIvMPEGDRS 162 Bacillus subtilis
Q92BX2       89 REVAIPMAVGSQSAALknssLIDTYQVVREVnpkgiILANVSPevdiQDGIRAIEMLEADALQIHINPAQELvMQEGDRS 168 Listeria innocua
Q88WB6       86 AACGLPIATGSQSVAIkdpqVAPTFATMRDHnpnglIFGNLGAghplSAAQTAIAMLQADALELHLNVVQEIvMPEGDRD 165 Lactobacillus pl...
Q8DUI9       79 DTCGLLFVTGSYSTALk--nPDDTSYQVKKSrphllLATNIGLdkpyQAGLQAVRDLQPLFLQVHINLMQELlMPEGERE 156 Streptococcus mu...
YP_194040    84 NEENIALALGSTSILAkekeQLDSFYIARIEdpngiLIANVNPetpvQTVKDIVHELHADALQIHINTIQEIaMPEGDRN 163 Lactobacillus ac...
ZP_00875670  88 HFGKIALASGSVSAAIkdpsVAETFSVMRREnpygiIFANLGAhhsvENAKRAVDLLEANAIQIHVNAPQEIvMPEGDRD 167 Streptococcus su...
YP_395516    89 QIAGLPMATGSQSVAIkdptLVDTFSVIREFnpagfILANIGAgndlSVAQKAVAMTQANALEIHVNTAQEVvMPEGDRE 168 Lactobacillus sa...
YP_535575    84 AKTNIPMACGSQSIALkypsLSPNFSKIRQLnpngfLLGNLGAghsySNFNVAQQMIDANAMELHLNVSQELvMPEGDTE 163 Lactobacillus sa...
ZP_01273286  88 HKHHLAMATGSLSIISkdpqSFSSFEIIREEnpdgiIFANLSAnaslDQAINAISLLKANALELHINAAQELiMPEGDRD 167 Lactobacillus re...
YP_795034    86 AATGMAVASGSQSIALkdeqAIPTFTSLRENnpdglVFANIGAghdvRAAKHAVQMLAANALEIHVNTAQELvMPEGDRD 165 Lactobacillus br...
Feature 1                            #                                                          
1P0N_A      163 FsgALKRIEQICsrvsVPVIVKEVGFGMSKASAGKLYEAGaaAVDIGGYGGTNFSKIENLRRQrqi-sfFNSWGISTAAS 241 Bacillus subtilis
Q92BX2      169 FshWLSRIEAYVknspVPVVVKEVGFGMTRETVKTLAEIGvtTVDLAGKGGTNFAQIENDRRRdqaynfLLDWGISTGQA 248 Listeria innocua
Q88WB6      166 Fh-WLTNISDLVqaltVPVIVKEVGFGISRPTMQQLYAAGvrYLDLGGHGGTNFVDIENRRRAnrdmayLHDFGLTTVES 244 Lactobacillus pl...
Q8DUI9      157 FrsWKKHLSDYAkklqLPFILKEVGFGMDVKTIQTAIDLGvkTVDISGRGGTSFAYIENRRGGnr--syLNQWGQTTAQV 234 Streptococcus mu...
YP_194040   164 Ff-WLNNIKEIRaeidIPIIIKEVGFGLDQNTIHILKNEGisYFDIAGSGGTNFAQIENARNKydv-syLEDIGLPTVIS 241 Lactobacillus ac...
ZP_00875670 168 FtmWLKNIETLVreveVPVIVKEVGFGMSRETVAQLASVGvqTIDVSGTGGTDFAKIENARRTfndytyLEGWGQSTVTS 247 Streptococcus su...
YP_395516   169 Fy-WLDQIGEIVanldVPVIVKEVGFGMSAETIAKLQSVGvtNIDVSGKGGTNFVTIENERRRdkaydyLSDWGQSTVES 247 Lactobacillus sa...
YP_535575   164 Fv-WKDNIREIVnnssFPLLVKGVGQGLTPMTIKELADIGvkYIDLSGKGGTNFIEIENRRRKqkelafLQDIGMTTAQS 242 Lactobacillus sa...
ZP_01273286 168 Fn-WLDNIQYLVseleVPVIVKEVGFGMSKTTIAKLQTHDvhLINVSGRGGTNFAAIENRRNHdinfesLLDWGQTTPES 246 Lactobacillus re...
YP_795034   166 Fh-WLDHIGNIVaaldVPVIVKEVGFGMAQETLQKLQHVGvkLVDLGGRGGTNFVDIENFRRHqkelnyLDTWGQSTVES 244 Lactobacillus br...
Feature 1                        ###                     #                                      
1P0N_A      242 LAEIRSefp--asTMIASGGLqdALDVAKAIALGASCTGMAGHFLKALtds---geEGLLEEIQLILEELKLIMTVLGAR 316 Bacillus subtilis
Q92BX2      249 LIDMQHada-pkiAYLASGGIrnPLDIVKALALGADSVGMAGQIISSLkkd---gvSKTIEKLELWKEQLRGLFVLANAK 324 Listeria innocua
Q88WB6      245 LLGVQNrpd--dlTVLAAGGVrqPLDILKALMLGADAVGMAGTVLHALlhh---tdDEVIAMLTDWQSQLKRLFALVGVT 319 Lactobacillus pl...
Q8DUI9      235 LLNAQPlmd--kvEILASGGIrhPLDIIKALVLGAKAVGLSRTMLELVeqh---svHEVIAIVNGWKEDLRLIMCALNCQ 309 Streptococcus mu...
YP_194040   242 ALMAQKeq----vDFIVSGGVrnPLDVLKGLTLGGQYVGISNVFLQKFndq---gyDGLQQLIAEWKEQLAALIAVYGKN 314 Lactobacillus ac...
ZP_00875670 248 LVEAMSvseevrpSLIASGGIktPLDIVKSLALGADLVGMSNHFLQYVkdgkghrfDDGLQAIKTYQWQMAEIMTMLGAK 327 Streptococcus su...
YP_395516   248 LFESQAfqt--elTILASGGIrnPLDIVKALRLGASAVGISGQILHMLikt---gpTETAEQLLAWQAQIQSIMAILGAR 322 Lactobacillus sa...
YP_535575   243 LVAAKLvde--diSFTASGGIrnSLDIVKCLVLGADNVGISGLFLHILlrq---gtESLIEYITNLKIEIKKIMLMLGCK 317 Lactobacillus sa...
ZP_01273286 247 LLEAHSirr-gktEIIASGGItsPLDVIKAGVLGARAVGVAGYFLNILqne---gyEALDQTLGEWRVIVKRLLALLGCS 322 Lactobacillus re...
YP_795034   245 LFEARQqp---dlQVIATGGIrqPLDAAKALALGARVVGSAGQILHSLikt---deATTTAMLLDWQVGLRTIMTLLGTT 318 Lactobacillus br...
Feature 1              
1P0N_A      317 TIADLQK 323 Bacillus subtilis
Q92BX2      325 NIAELKE 331 Listeria innocua
Q88WB6      320 RVDQFKS 326 Lactobacillus plantarum
Q8DUI9      310 TIAELRN 316 Streptococcus mutans
YP_194040   315 DLVSLTE 321 Lactobacillus acidophilus NCFM
ZP_00875670 328 NIAELRQ 334 Streptococcus suis 89/1591
YP_395516   323 NLTALQS 329 Lactobacillus sakei subsp. sakei 23K
YP_535575   318 NIDDLHK 324 Lactobacillus salivarius subsp. salivarius UCC118
ZP_01273286 323 SFTELSR 329 Lactobacillus reuteri 100-23
YP_795034   319 DLTQLRQ 325 Lactobacillus brevis ATCC 367

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