1HZF,1GHQ


Conserved Protein Domain Family
complement_C3_C4_C5

?
cd02896: complement_C3_C4_C5 
Click on image for an interactive view with Cn3D
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Statistics
?
PSSM-Id: 239226
Aligned: 32 rows
Threshold Bit Score: 289.559
Created: 30-Aug-2005
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    ####                                                              
1HZF_A      40 SPGGVASLLRLPRGCGEQTXIYLAPTLAASRYLDKTEQWstlppet---kdhavdlIQKGYMRIQQFRkaDGSYAAWLSR 116  Homo sapiens
AAB60608   922 DGNNMNHLIVVPAGCGEQNMISTTPSVIATRYLDASGQWervgvnr---rdqalknMRQGYAQQMAFRkpDNSYAAWKDR 998  Xenopus laevis/g...
XP_696246  620 SGAAMGSLIIQPGGCGEQNMMGLTMPGIATHYLDKTNQWhtvragl---rqtateyIRKGYNQELAYRksDGSFAAWINR 696  zebrafish
XP_700378  242 SGSFMGQLIVQPHGCGEQNMIFMTLPVIATHYLDSTNQWeaigmkr---rdeaighIKTGYNRQQAYRkpDGSYAAWIDR 318  zebrafish
AAD30201   239 DGANLKHLIQVPQGCGEQNMITMTPAVISTHYLDKTNQWdrlgqdr---raqaikyITQGYTQQMAFRqpSNAYAAFTNR 315  marbled lungfish
XP_694282  677 KEDSLAALIRMPGGCVEQNLARITLPLIAAHYLDRSADWeivgisr---reeaikyIQKGYENQLNYKksDDSYPPYANE 753  zebrafish
XP_542077 1214 TSKETWKLLRVPTGCPEQTLSSLAPVIILTHYLDTTGHWgkvgvel---reqviknIVSGYTQMLTHRseHGTYHTSKGN 1290 dog
CAG06013   810 SPMSTHIYVTAGRRCGEENIIHTSLTVTATRYLDLTNQWeavnidr---rnealqhIRSGYQKQLANRlkDGSFAACPDD 886  Tetraodon nigrov...
XP_415405  608 SPEGLSILTNLPKGSAEAELMTIAPVFYVFHYLEASNNWhilgpetltsrtamrrkMKEGIVSVLSFRnsDFSYSMWKNG 687  chicken
P01031     993 SQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWnifhsdpliekqklkkkLKEGMLSIMSYRnaDYSYSVWKGG 1072 human
Feature 1                                                              #                       
1HZF_A     117 DSSTWLTAFVLKVLslaqeqv---ggspekLQETSNWLLSQ-QQADGSFQDPCPVLDrs--xqGGLVgn--dETVALTAF 188  Homo sapiens
AAB60608   999 PASTWLTGYVAKVFgmaqefi---dieanvLCGSVKWLILEkQKPDGLFQENAPVIHqe--mvGGITtgaaeGDSSLTAF 1073 Xenopus laevis/g...
XP_696246  697 PSSTWLTAYVAKVFamasdii---hidqnvICSALRWLIMNrQLPNGVFRENAPVIHge--mtGNVQgs--nSEASMTAF 769  zebrafish
XP_700378  319 PSSTWLTAYVAKIFamandli---tieeqvLCSALKWLVLNrQLPDGSFEEKAAVVHge--mvGDVQgr--dAEASLTAF 391  zebrafish
AAD30201   316 PASTWLTAYVVKVFsmahqli---aidpqvLCGAVKWLILEkQKPDGIFKEDAPVIHge--miGGFKga--ePDATLTAF 388  marbled lungfish
XP_694282  754 GTSTWITAYVVKVFsmahsfi---tvnekhLCGPLLYLLKNkQGYDGTFQEDNPVYDts--mtGAMRgs--eYKASLTAF 826  zebrafish
XP_542077 1291 PGSTWLTSYVFRVFalaypimatsvldlhsLCTTANWIITQrQAEDGHFLEEGAVIMaw--mqGGYRgs--eAHISLTAL 1366 dog
CAG06013   887 QHSAWLTAFVVKVLamadklv---gvqrsvVCDAVTFLISRaQEPRGLFREFGQVFDkt--mmGDVLgv--dSDVSMTAF 959  Tetraodon nigrov...
XP_415405  688 KASTWILGQVNQYInld----------qisVCNSLLWLIDNcQMPDGSFSEFSDYQPvklqgtLPREak--eKSLYLTAF 755  chicken
P01031    1073 SASTWLTAFALRVLgqvnkyv---eqnqnsICNSLLWLVENyQLDNGSFKENSQYQPiklqgtLPVEar--eNSLYLTAF 1147 human
Feature 1                                                                                      
1HZF_A     189 VTIALHHGlavfqdegaeplkqrveasISKASSFLGEKasagllGAHAAAITAYALTltkapadlrgvAHNNLXAXAQET 268  Homo sapiens
AAB60608  1074 ILIAMLECqrtcneh-----vnnlqvsIDKASSYLVGQypg-lkKPYSIAITSYALAlag-----klpNTNKLLSASIGN 1142 Xenopus laevis/g...
XP_696246  770 VTIALQEGrsrcngq-----vssldssIYKAIAYLKSQlqg-liNPYAVAMASYALAnan------slNKQVLMSKASAD 837  zebrafish
XP_700378  392 VTIAMQEGrelcgai-----vgslpesIRKAVSFLEGKlnk-ltNPYAVALTSYAMAgad------klNKAVLMKFSTKG 459  zebrafish
AAD30201   389 VVIALSEAreichkf-----vgslddsIKKAIVYLNSQyer-lqRTYSIAIVSYALAmsn------hlETPKRWMKASTD 456  marbled lungfish
XP_694282  827 VLIALAEAqdkvtcqd---qevnirdkSRQAAGYLTEHfsr-ltRPYTAAIACYALAvsn-----nacVKSMLLKFASPD 897  zebrafish
XP_542077 1367 VLIALNEGkdlcrgi------qsltasMERARSFLEEClpk-iqTTFAVAIVSYALAltn-----sprANDRLDSFASHD 1434 dog
CAG06013   960 CLIAMQESqslcplv------ngwqgsKEKAATYLEMRlrt-lvNPYAVAMASYALAned------kqYYNTLFKFASPD 1026 Tetraodon nigrov...
XP_415405  756 SIIGIEKSikicpt-------qkihdaKNKAGDYLLTNvqs-aqSPFTMAIISYALAlvdl----nhqAARSLFSALKRE 823  chicken
P01031    1148 TVIGIRKAfdicpl-------vkidtaLIKADNFLLENtlp-aqSTFTLAISAYALSlgdk----thpQFRSIVSALKRE 1215 human
Feature 1                                                                                      
1HZF_A     269 GdnlywgsvtgsqsnavsptpaprnpsdpxpQAPALWIETTAYALLHlllhegkaexADQASAWLTrqGSFQGGFRSTQD 348  Homo sapiens
AAB60608  1143 Thwe-------------------------epGKRFISLETTSYALLTllkmk-efdlTGGIVRWLNeqRYYGAVYGSTQA 1196 Xenopus laevis/g...
XP_696246  838 Kshw------------------------pvpGSSSFTLEASSYALLAlvklh-dyqnTAPIVNWLNnqRQYNGGYGTTQA 892  zebrafish
XP_700378  460 Eagty----------------------wnvpGQQYHTREATSYAVLAlvkar-dfnaAGEAVHWLGsqHYSYGGSGTTQA 516  zebrafish
AAD30201   457 Mnhw------------------------rdaASDQYTFEATAYSLLTliklq-kfdfAGPVVRWLTekRFFGGGYGSTQS 511  marbled lungfish
XP_694282  898 Hshw------------------------pdsNNYFFTLEATGYALLAliksg-hmeeAEAPFRWLNehRGIGGGYGSTQS 952  zebrafish
XP_542077 1435 Kthwp----------------------vdnlEDSLYTIEATAYALMQkvelg-rhneTHAIAKWLLekRELGGGFKSTQT 1491 dog
CAG06013  1027 Rshw------------------------qvpPGRVYALEATAYALLAlvrsk-afeeATPVVRWFNkqQRVGGGFGSTQA 1081 Tetraodon nigrov...
XP_415405  824 Asvigdppiyrfwk-----ddfktsdllapsPVTAQMVETTAYALLTallrg-dknyANPIIKWLSeeQRYGGGFYSTQD 897  chicken
P01031    1216 Alvkgnppiyrfwk-----dnlqhkdssvpnTGTARMVETTAYALLTslnlk-dinyVNPVIKWLSeeQRYGGGFYSTQD 1289 human
Feature 1                 
1HZF_A     349 TVIALDALSAY 359  Homo sapiens
AAB60608  1197 TIVMFQALAQY 1207 Xenopus laevis/gilli
XP_696246  893 TIMVFQAVAEY 903  zebrafish
XP_700378  517 TIMVFQAVAEY 527  zebrafish
AAD30201   512 TIMVLQAVAQY 522  marbled lungfish
XP_694282  953 TMVVLQALSEY 963  zebrafish
XP_542077 1492 TVVALEALTRF 1502 dog
CAG06013  1082 TVLVYQALAEF 1092 Tetraodon nigroviridis
XP_415405  898 TVNALEALTEY 908  chicken
P01031    1290 TINAIEGLTEY 1300 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap