Conserved Protein Domain Family
TCP1_gamma

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cd03337: TCP1_gamma 
TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), each ring of the eukaryotic cytosolic chaperonin (CTT) consists of eight different, but homologous subunits. Their common function is to sequester nonnative proteins inside their central cavity and promote folding by using energy derived from ATP hydrolysis. The best studied in vivo substrates of CTT are actin and tubulin.
Statistics
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PSSM-Id: 239453
View PSSM: cd03337
Aligned: 21 rows
Threshold Bit Score: 703.285
Threshold Setting Gi: 19069275
Created: 6-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:stacking interactions
Evidence:
  • Comment:interactions of one subunit to subunits of the second ring
  • Comment:annotation based on structure of bacterial homolog GroEL

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
CAA89305    4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDpmGGLVLTNDGHAILREIDvaHPAAKSMLELSR 83  baker's yeast
CAA20112    4 PVFVMNTNGNRQVGHKAQMSNIQAAKAVADVIRTCLGPRAMLKMLLDpvGSVLLTNDGHAILREIEvaHPAAKSMIELAR 83  fission yeast
XP_762214   6 PVFVMNTGPERQTGRKAQISNITAAKTVADVIRTCLGPKAMLKMILDpmGGILLTNDGNAILREVEvaHPAAKSMIELSR 85  Ustilago maydis 521
AAX79676    6 PVIVLNQKMERQTGRKAQLNNIEAARVVSGLISSTLGPCAMLKMILDpmGGTVLTNDGNCILREIDvvHPAAKHMLELAR 85  Trypanosoma brucei
CAA72704    6 AVFILNQNAKREQGRKAQTANIKAARAVSDIVRTTLGPKSMLKMLLDpmGGIVLTNDGNAILREIDvaHPAAKSMIELAR 85  Oxytricha granulifera
XP_665304   5 QVLVVQQPSQRDQGRKAQLRNIQAGKTVADVVRTTLGPKAMLKMLLDplGGIVLTNDGNSILREVDvaHPGAKSIIELSR 84  Cryptosporidium ho...
XP_640613   4 PVFVLNTNAKRENQKEAQQGIFLAVKSVASIIKTCLGPKAMLKMILDpmGTTVVTNDGNAILREIDvtHPAAKSMIELSR 83  Dictyostelium disc...
EAL44772    4 PVLVLNTNTKRENGRKAQLANIMAGKTVADLIRTCLGPKSMLKMLIDpqAGVTITSDGNSVLRDLTveHPAAKYMIELSR 83  Entamoeba histolyt...
XP_770673   4 QVYVLSQGTESERREMARMNNIKASKTVADVIRTTMGPRSMLKMILDsmGSVVMTNDGNAILRELDvaHPAAKAMLEVSR 83  Giardia lamblia AT...
EAN31441    5 MYLVFKPSLKKESDRKAQLATIQASKALSDIVRTTLGPRSMLKMLLDpmGGIVITNDGNSILREIDvnNPGAKSLIELSR 84  Theileria parva
Feature 1                                                                                     
CAA89305   84 TQDEEVGDGTTTVIILAGEILAQCAPYLIEkNIHPVIIIQALKKALTDALEVIKQ----VSKPVdv------enDAAMKK 153 baker's yeast
CAA20112   84 TQDEEVGDGTTSVIILAGEILAAASPLLDR-KIHPVVMIRSFKQALEDALSIIDE----ITLPVnv------ddNAEMFR 152 fission yeast
XP_762214  86 TQDEEVGDGTTSVIILAGEILAQSLPQLER-SIHPVVIISAFKKALARALEIVEE----ISVPVdv------tnDKDMLA 154 Ustilago maydis 521
AAX79676   86 AQDEEVGDGTTSVIILTGEILSLSKPLLER-GIHPLKIVKGFSLALTDALAAIEK----IATSIdp------ndIKQLEE 154 Trypanosoma brucei
CAA72704   86 AQDEEVGDGTTSVIILAGEILSAVESFLER-DIHPTVIVGAYFQALEEIVRLTES----YGEPIdi------enENDLQK 154 Oxytricha granulifera
XP_665304  85 TIDEEVGDGTTSVVVLAGEFLACAEPLLQK-NIHPTIIAKGYLRALDDSIKFMEE----MSVKLdv------nnKESLVS 153 Cryptosporidium ho...
XP_640613  84 AQDENVGDGTTSVVILAAEVLASSELFIEK-KIHPHYIIKAFRMALDDSLSIVDQy--sVAIDLk--------nRPEVLK 152 Dictyostelium disc...
EAL44772   84 TQDETVGDGTTSVVILCGEVLQVAEPWIQK-GIHPTIIISGFLDALEDALESLHE----ISTTIdlsn--pkvvSGVVRS 156 Entamoeba histolyt...
XP_770673  84 AQEEQVGDGTTSVVILAGEVIAMAEPLLKC-GIHPILITQGYQKALDFLLSEAERssfeINIKGieilglkseaAGPIMT 162 Giardia lamblia AT...
EAN31441   85 SLDEEVGDGTTSCVILCGELLSNCASLIKK-EIHPTEIIQGLMEALDDALKALDN----ISIPVni------ndHNKLLQ 153 Theileria parva
Feature 1                                                                                     
CAA89305  154 LIQASIGtkyv----------ihwSEKMCELALDAVKTVRkdlgqtvege------------------pnfeidikrYVR 205 baker's yeast
CAA20112  153 LIRTCIGtklv----------arwSDLMCHLALRAVRTVAstsngrm------------------------eidikrYAR 198 fission yeast
XP_762214 155 LIKTSIGtkfv----------srwSEQMCKLALKAVRTVAmvdstagssas---------------sdpsktvdikrYAR 209 Ustilago maydis 521
AAX79676  155 VVRACLGtkyn----------sheDDLMCKMAVEATLRVVvenkvtgq----------------------kevdikrYAK 202 Trypanosoma brucei
CAA72704  155 IVSSCIGtkfs----------skwGNLIVDLAVKAVKSVYkkegdyv------------------------eidvkrYAK 200 Oxytricha granulifera
XP_665304 154 VVDSCLKtkfs----------grwGSLISSMALKAAETVSiansgsp-----------------------keidikrYVR 200 Cryptosporidium ho...
XP_640613 153 VVQSCIGtkfi----------gkwGSLMCNLALDAVMTVHiqeedgr-----------------------seidikrYAK 199 Dictyostelium disc...
EAL44772  157 CIGTTFMnt--------------wNDILCKLAIEAVTICAggdlmkakg--------------------kedidtkrYAR 202 Entamoeba histolyt...
XP_770673 163 VLKNSLStkfv----------srwMDLMCNLALEAVSIVArgrgaevrkglvgvtkdarskgdeaelgasvdidikrFCR 232 Giardia lamblia AT...
EAN31441  154 IIQSSLStkfsnrwgdlisklaldSIFKLHKSTHNRTNGTnctnglngvsdg-------------lpdavkpldikrLIK 220 Theileria parva
Feature 1                                                                                     
CAA89305  206 VEKIPGgdvlDSRVLk-gVLLNKDVVHPkmsrHIENPRVVLLDCPLEYkkgesqtnieiekeedwnril-qieeeqvqlm 283 baker's yeast
CAA20112  199 VEKVPGge-iESSCVldgVMLNKDVTHPkmrrRIENPRIVLLDCPLEYrkgesqtnieiskdtdwnril-eieeeqvkrm 276 fission yeast
XP_762214 210 VEKVPGgtieDCRVLd-gVMLNKDVTHPkmrrRIENPRIILLDCPLEYkkgesqtnieitreedwnkil-eieeqqiqam 287 Ustilago maydis 521
AAX79676  203 IEKIPGgsvsDSVVLd-gVMFNKDHIHPkmrrYIEKPRILLLDCPLEYkkpettinvevgqatdwelll-kqeedyvrgl 280 Trypanosoma brucei
CAA72704  201 VEKIPGglleESVVLd-gVMFNKDVTHPgmrrYIENPRVVLLDCPLEYkkgesmtnmeftkeedfkkalmmeeeevkkmc 279 Oxytricha granulifera
XP_665304 201 IEKIPGgeieDSYVLd-gVVVNKDVVHPrmkrLIINPKVLLLDCTLEYkkgesqtnveitkeadweall-rqeeeeveam 278 Cryptosporidium ho...
XP_640613 200 VEKIPGgdisDCRVIr-gVMLNKDVTHPkmkrMIKNPRIVLLDCSLEYkkgesdtmvditneddfsall-kieeeyvqri 277 Dictyostelium disc...
EAL44772  203 VEKIAGgefsESMVVk-gVVLNKDVVHSkmrrRIDKPRVVLLDCSLEYtkgesqtdvevttatdfgkli-eleeqyvkrl 280 Entamoeba histolyt...
XP_770673 233 IEKIPGatveDCCVId-gVVLNKDVIHPdmrkYIKNPRILLLDCPLEYkkaqsmmnvelfqgksdlgdilkveedyirth 311 Giardia lamblia AT...
EAN31441  221 VEKIIGgyieDSKVLd-gVVVNKDVVHAnmsrRIENPRILILDCTLEYkkgesqtmvdiydesvwnkll-lqeeteikqm 298 Theileria parva
Feature 1                                                                                     
CAA89305  284 ceqilavrptLVITEKgVSDLAQHYLLk-gGCSVLRrvKKSDNNRIARVTGATIVnr-vEDLKESDVGTNCGLFKVEMig 361 baker's yeast
CAA20112  277 cdyiiavkpdLVITEKgVSDLAQHYLLk-aNITALRrtRKSDNNRIARACGANIVnrleDLREKDVGTGCGLFYIDKLgd 355 fission yeast
XP_762214 288 cekiiefqpdLVFTEKgVSDLAQHYLLk-aNITCIRrvRKTDNNRIARATGATIVnrvdDLRDADVGTRCGLFHIEKLgd 366 Ustilago maydis 521
AAX79676  281 cqtiisfkpdVVITEKgASDLAAHFLHk-aQITCIRrlRKTDNNRIARATGATIIsr-vAELTEDHIGHAGLMEIKKIgd 358 Trypanosoma brucei
CAA72704  280 aedilrvkpdVVITEKgVSDTAQHFLLkygNCTVIRriRKTDNNRIARVTGATIAnr-pEELQESDVGTKCGLFEIKKig 358 Oxytricha granulifera
XP_665304 279 ckdiiatgcnVVFTEKgVSDLAQHFLVk-aGISVIRrvRKSDNNRIARVTGATIAsr-tEELTPNDLGTCCGRFEVKKig 356 Cryptosporidium ho...
XP_640613 278 cediiklkpdLVFTEKgVSDLAQHFFVk-kGITCLRrlKKSENNRIARISGATIVsr-tDELQESDIGTGCGLFEIRKig 355 Dictyostelium disc...
EAL44772  281 ceniirvkpdLVITEKgISDIAQHYLQk-aGISALRrvRKNDNLRLVRATGASIVyr-tEDLKETDVGVAGLFEVKKIgd 358 Entamoeba histolyt...
XP_770673 312 vekilsfkpdLVITEKgVADQATHMFVq-hGVTVLRrvRKTDNVRLAAVSGATIVsr-vEELQESDVGTYAGLYELQKig 389 Giardia lamblia AT...
EAN31441  299 cqyiinsncnLVVTEKgVSDLAQHYLVk-aGISCLRrvRKSDTNRISKACGATIVnr-pEEITESDIGHRCKLFHVDKig 376 Theileria parva
Feature 1                                                                                #    
CAA89305  362 deYFSFLDNCKe-pKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSpSLSPGGGATEMAVSVKLAEKakqleGIQQW 440 baker's yeast
CAA20112  356 -eYYTFLTGCKn-pKACTILLRGPSKDIINEVERNLQDAMAVARNVFFHpKLSPGGGATEMAVSVRLAEKarsieGVAQW 433 fission yeast
XP_762214 367 -eYFTFLEECKe-pKACTILLRGPSKDILNEIDRNLADAMAVARNVVFNpLLAPGGGATEMAIAYGLSEYakeleGVEVG 444 Ustilago maydis 521
AAX79676  359 -eYFTFITGCTs-gKACSVVLRGASKDTINEMERNLHDAMCVARNIILEpRVVYGASALEMYVSSYLMNRsksitGVQQA 436 Trypanosoma brucei
CAA72704  359 deYFSFMTKCEn-pKACSILLRGASKDVLNEIERNLHDALGVARNVMVNpKLVPGGGAIEMELACRLMEFsqkieGMQQW 437 Oxytricha granulifera
XP_665304 357 deYFCFLTESKt-pKACSILLRGGSKDVLNELERNLHDALAVARNILLDpALLPGGGGTEMAISCYLNEKsfsidDTQVW 435 Cryptosporidium ho...
XP_640613 356 deYFTFLEDCKe-pKACTILLRGASKDILNEVERNLTDALNVARNIVLDpRLVPGGGAIEMALSQALSEKsksieGLHQL 434 Dictyostelium disc...
EAL44772  359 -eYYAFISECEk-sTACTILLRGGSKDVLNEVERNLQDAMASCKNLIARpELVPGGGASEMHIATTLSKKaknieGKKQW 436 Entamoeba histolyt...
XP_770673 390 deFFSFIHQSGgkaSACTIVLRGASKSTLLEIERNIQDAMHVCRNIILDpRLVIGGGCFEAHLSTALSQYadtlvGKPQL 469 Giardia lamblia AT...
EAN31441  377 deYYSFFDLCTd-pKACSILLRGSSKDVLNEIERNLYDALSICRNIIYNcKLLPGGGATEVYISNFLNQQisrkvGLRRL 455 Theileria parva
Feature 1                  #        #       ##  #                                             
CAA89305  441 PYQAVADAMECIPRTLIQNAGGD------PIRLLSQLRAKhaqg------nftTGIDGdkgkiVDMVSYGIWEPEVIKQQ 508 baker's yeast
CAA20112  434 PYRAVADAIEIIPRTLVQNCGAN------PIKALTELRAKhaeg------qhsFGIDGetgrvVDMHEYGVWEPEAVKLQ 501 fission yeast
XP_762214 445 PIRAVSDAMEVIPRTLIQNCGGN------AIKTLTTLRAKhang------qhsYGVDGetgkvVEMKEYGLYESAAVKIQ 512 Ustilago maydis 521
AAX79676  437 AYQAVAMALEVVPRILTSNCGAN------VIRTVTELRARhamp-----dgdyWGVDGttgdiVDVRSLRVVEPAAVKVQ 505 Trypanosoma brucei
CAA72704  438 PFKALAGALEVIPRTLAQNCGAD------VVRVMTELRAKhandk----eglyWGIDGntgkiRDMRESNVWDPISVKQQ 507 Oxytricha granulifera
XP_665304 436 AYKAFAQALEIIPKTLAQNCGAN------VMKTLTLLKSHylpssatrgqkpvHGINGctgaiTNVTELGIWDTLAVKQQ 509 Cryptosporidium ho...
XP_640613 435 PYKALAQSLECIPKILAQNCGAN------TVKLLTELRAKhatnp---tenytYGVDGdngtiVDMKQLGIWDTHSVKVQ 505 Dictyostelium disc...
EAL44772  437 PYSSIAVAMEVIPRTLAANCGVD------VVKVITELRAKhisnk----enstFGIDGmkgtiVDMKELGVWEPYEVKAQ 506 Entamoeba histolyt...
XP_770673 470 VIKAVAKSLEVIPRTLLQNCGGN------IIRTITELKAAhtsd-----pncqLGVDGvtgllVNCKEQGIWDPLSTKLQ 538 Giardia lamblia AT...
EAN31441  456 SYECASKAFQVIPKTLAQNCGVNpstalrAGNSCLKLMSDlllmhg--ngevhMGINGetgqiINVVNHNLYDIFLVKSQ 533 Theileria parva
Feature 1                          
CAA89305  509 SVKTAIESACLLLRVDDIVSG 529 baker's yeast
CAA20112  502 SIKTAIESACLLLRVDDIVSG 522 fission yeast
XP_762214 513 TLKTAIESASLLLRVDDVVSA 533 Ustilago maydis 521
AAX79676  506 ALKTAIEAASMILRVDDVVSG 526 Trypanosoma brucei
CAA72704  508 TLKTSIEATCMLLRIDDIVSG 528 Oxytricha granulifera
XP_665304 510 VYKTAVEATLMLLRIDDVLSS 530 Cryptosporidium hominis
XP_640613 506 TLKTAIESACTMLRVDHIASA 526 Dictyostelium discoideum AX4
EAL44772  507 CIKTAIEAACTLLRVDDVVSG 527 Entamoeba histolytica HM-1:IMSS
XP_770673 539 VLKAAIENACMILRVDDIFSC 559 Giardia lamblia ATCC 50803
EAN31441  534 IYKSSFESVSHCLLCLYVIED 554 Theileria parva

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