Conserved Protein Domain Family
RhoGAP_ARAP

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cd04385: RhoGAP_ARAP 
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.
Statistics
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PSSM-Id: 239850
View PSSM: cd04385
Aligned: 13 rows
Threshold Bit Score: 257.622
Threshold Setting Gi: 71004252
Created: 14-Apr-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative GTPasecatalytic
Feature 1:putative GTPase interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                       # 
XP_426346     935 DGNALQDQQLSk-nDVPIIVNSCIAFVTqyGLGSKHIYLKNGNSsnvAELLESFKKDARsvklr-agkhqLEDVTDVLKS 1012 chicken
XP_414522     358 RGNALRDQQLSr-gDIPIIVDSCIAFITqyGLRHEGIYRKNGAKsriKVLMEEFRRDARnvklr-isdnfIEDVTDVLKR 435  chicken
XP_687312    1046 KGNTLKDQQLSr-nDIPIIVDSCIAFITqyGLGHEGIYRKNGAKsriKLLMEEFRKDARnvklr-igdnfIEDVTDVLKR 1123 zebrafish
NP_071926     905 GGTGLQEQQMSr-gDIPIIVDACISFVTqhGLRLEGVYRKGGARarsLRLLAEFRRDARsvklr-pgehfVEDVTDTLKR 982  human
XP_700481     426 GNERLSQQQLTd-lGIPVTIDRCLDHITryGLLSPGIYRLSGINshvTKLLDKFQNNARtvtwc-eseysVHDVANTLKR 503  zebrafish
BAA34502      787 MGDTLSEQQLGd-sDIPVIVYRCVDYITqcGLTSEGIYRKCGQTsktQRLLESLRQDARsvhlk-egeqhVDDVSSALKR 864  human
BAA25506     1041 DGNALQDQQLSk-nDVPIIVNSCIAFVTqyGLGCKYIYQKNGDPlhiSELLESFKKDARsfklr-agkhqLEDVTAVLKS 1118 human
NP_573183     769 NGFSLGDQQLTr-yDVPVIVDKCINFVYihGSMSEGIYRKSGSEnsmHKLMSAFRADAFnveit-rneynEHDVANVLKR 846  fruit fly
XP_756792     528 DYPLTVPYRLRdtvAPPLIVTKCIDFIEmhAINLPGIYRISAKQssvKQLALAIEKDELgfqfd-pakdePAAVAGVFKD 606  Ustilago mayd...
XP_970036     661 NGAHLDQQQLTk-nDIPVLVEKCINFIYthGSMTEGIYRRPGTNtavAEILAKFRKDAWavqlt-idkytEHDVATALKR 738  red flour beetle
AAC71136      571 PATRLENLRLTg-dNIPVIVDKCIRFVSayGMKCEGIYRRNGKVteaKTILTKLTEDPVgyypvhendetVYAVADVLRQ 649  nematode
FAA00122      725 CGPDLENQQVTs-eGVPIILEKCMTYVEqfGLTMRGIYRLNGTHsktSQLLGEFQQNARdtqmr-eselnVHDVASALKR 802  Ciona intesti...
XP_001123079  866 CGPALEQQQLTq-dNVPVILDKCINFIYahGIMSKGIYRQNGSNsavVKLLKAFRRDAWatqit-rnaytEHDVATVLRR 943  honey bee
Feature 1           #                                                                       #  ## 
XP_426346    1013 FLSQIDDAILTk-ELYPFWISAldmq--nekeRVMKYGAFIRtLPPVNKATLAALIEHLYRVQKCSEINHMNPHNLALVF 1089 chicken
XP_414522     436 FFRELEDPVFTl-ELHPQWKEAaais--skpqRLERYKELIHrLPRLNRKTLAALIGHLYRVQKCADLNQMSTKNLSLLF 512  chicken
XP_687312    1124 FFREIDDPIFMa-DLHPFWKEAakip--lktqRLDRYKELIRgLPRVNRTTLAALISHLYRVQKCADLNQMCTKNLSLLF 1200 zebrafish
NP_071926     983 FFRELDDPVTSa-RLLPRWREAaelp--qknqRLEKYKDVIGcLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLF 1059 human
XP_700481     504 FLREVKGGVFNgqENNASWLRVagle--dgceKIQRYQILLSnLPDINREALKVLIHHLVCVQNLSNENQMTIRNLGIVF 581  zebrafish
BAA34502      865 FLRDLPDGLFTr-AQRLTWLEAseie--deeeKVSRYRELLVrLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVF 941  human
BAA25506     1119 FLSDIDDALLTk-ELYPYWISAldtq--ddkeRIKKYGAFIRsLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVF 1195 human
NP_573183     847 FMRDLPERLLG--KLTDSFVFVtela--vaseKIPIYRELLArLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIW 922  fruit fly
XP_756792     607 YLRQLPEPVLA--IPWAERIKYthereehirtGFATLKGKIRrLPPIHQITLKVIVQHLSRVAHHADQNKMTAANLSVVF 684  Ustilago mayd...
XP_970036     739 FIRDIPEPVLT--NSQRQYLHQvslvk-nkdeRIRMYKAALDqLPPISYKTAKKLLGHLHFIASQSKKNLMNVDNLAAVW 815  red flour beetle
AAC71136      650 FFRKLDAPLFPs-SSQADLFDLates--qsdeLCARYAQLINtFELVHRSTLKKLIGHLKNVSEHAQENRASVENLAKVF 726  nematode
FAA00122      803 WFKSLPGSLLTs-SLHDEWIDTaeikqehqdrKLEWYKHLIAkLPDINRSTLKVLLNHLNNVAGHEKENEMSRHNLAIVF 881  Ciona intesti...
XP_001123079  944 FLRDLPNPLFPp-NIHDRLCFTseti--neneRVSAYSKLLStLTPIPAATLRRILAHLHCLSQQSSKNLMTSENLSAIW 1020 honey bee
Feature 1                                  #          
XP_426346    1090 SSCLFqtk-----------gqTSEEVSVIEDLIKNY 1114 chicken
XP_414522     513 APSLFqtd-----------gkGEHEVKVMEDLIDNY 537  chicken
XP_687312    1201 APSLFqtd-----------gkGEHEVKIIEDLIDNY 1225 zebrafish
NP_071926    1060 APSVFqtd-----------grGEHEVRVLQELIDGY 1084 human
XP_700481     582 GPTLFqtd-----------gkDTTASQVVEELIQNY 606  zebrafish
BAA34502      942 GPTLFqtd-----------gqDYKAGRVVEDLINHY 966  human
BAA25506     1196 SSCLFqtk-----------gqTSEEVNVIEDLINNY 1220 human
NP_573183     923 GPTLLakksd-------eliySQKEADVLSDLVVLY 951  fruit fly
XP_756792     685 SPCLLseadhe----ttsvaaAMEEDKTMEDLILYC 716  Ustilago maydis 521
XP_970036     816 GPSLMhqeekdn--nsvgntkHVQNTVVVRQLLELY 849  red flour beetle
AAC71136      727 AASLFltdamde---kvfsesYNHQINVLIHLTTGY 759  nematode
FAA00122      882 GPTLMepqggkdngnkqmigqTSQEIGCIEDLLMYY 917  Ciona intestinalis
XP_001123079 1021 GPTLMhagen------saeewNRSETRVIGDLIKLY 1050 honey bee

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