Conserved Protein Domain Family
Piwi_ago-like
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cd04657: Piwi_ago-like 
Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the 5' anchoring of the guide RNA and the other, the catalytic site for slicing.
Links
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Statistics
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PSSM-Id: 240015
Aligned: 48 rows
Threshold Bit Score: 430.881
Created: 3-Oct-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site5' RNA guide
Feature 1:active site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
NP_036286  392 PYVREFGIMVKDEMTDv--tGRVLQPPsilygg--rnkaiaTPVQGVWDMRNkqfhtg---------------------- 445  human
AAF06159   467 NFVERFGLCSKLQMIEc--pGKVLKEPmlvnsvn-eqikmtPVIRGFQEKQLnvvpek---------------------- 521  Caenorhabditis e...
17976540   587 DYMKKHKLVMKREPIRv--kATILPPPtlvygd---svfhdEHHIGEWEAVThdpprqvldgavfrr------------- 648  Caenorhabditis e...
BAE60986   450 TILTRFGISTSRRLITv--eGRILDQPnvmyr----gnasvKQFSGSWNITStkfnvp---------------------- 501  Aspergillus oryzae
EAS32029   552 PTANALDISGQGLNLMg--vGRREGPKekfgidiahellsvKGMCGSWNFTGhlfrkag--------------------- 608  Coccidioides imm...
EAT81814   541 AKSLQNLLQISPTMLQip-sAQMEKLDiiygak---tsnqqPNTQAQWNLQNl--------------------------- 589  Phaeosphaeria no...
EAT81938   571 AGRRDLPLTISKSMLKv--dCSQLPYPkirygd---qsyniKPADAKWNLGDkqfls----------------------- 622  Phaeosphaeria no...
EAT81940   477 PFPAFPAIKIDSRMLQv--pATTLNPPkplyg-----kgsaSVSNGSWNLRDvkflttf--------------------- 528  Phaeosphaeria no...
EAT81960   666 TNFAGVGSPIRLTPTMlklpCRVLPLPqpkf-------sgaSPTNGNGKSRWkvpkqssffktep--------------- 723  Phaeosphaeria no...
EAT86396   524 TALSVFGIKVNPNLMTv--pGRILPPPqllyr----asatcNPRNGAWNLDPralgakpfrvaktlgswntlvinsgnrd 597  Phaeosphaeria no...

Feature 1                                                                                      
NP_036286  446 ---------------ieikvWAIACFAPQRQCte----------------------------------vhLKSFTEQLrk 476  human
AAF06159   522 ---------------elccaVFVVNETAGNPClee---------------------------------ndVVKFYTELig 553  Caenorhabditis e...
17976540   649 -----klyksseqplmkrlmGSILLIQSPRQCrdfdynqqgyhaimraiedsgqpvlwadenkhsaviqgELQFNQNQhg 723  Caenorhabditis e...
BAE60986   502 --------------gqrlrkWSYLLVSDKKVQdtf---------------------------------rdVKSFQPVVk- 533  Aspergillus oryzae
EAS32029   609 -------------hlpgtnpIGVITVGTFKSE--------------------------------------PEDFLKSLkq 637  Coccidioides imm...
EAT81814   590 --------------------KAFIDAPGNKAPakthnclwl--------------------veegivkdtVENYQETFgr 629  Phaeosphaeria no...
EAT81938   623 ---------------tknheRTVSYTVLHERSvdath-----------------------------idqiRQNFEVQLtk 658  Phaeosphaeria no...
EAT81940   529 --------------pkiafkVFMIAIPDGSHSaikgpe---------------------------ilhetFKGFQDVMqr 567  Phaeosphaeria no...
EAT81960   724 --------allkyrfvierrFKEANAELYHDQfqkel----------------------------lnrcnLKANQLQDlg 767  Phaeosphaeria no...
EAT86396   598 tiyggmqgvmqhltafratlETYGLNPGPVQPpv----------------------------------amDVSFNDLQnk 643  Phaeosphaeria no...

Feature 1                                                                                      
NP_036286  477 isrdagmpiqgq-----------pcfckyaqgadsvePMFRHLKNTya-------------------------------- 513  human
AAF06159   554 gckfrgiri------------------ganenrgaqsIMYDATKNEyafyknctlntgigrfeiaateaknmferlpdke 615  Caenorhabditis e...
17976540   724 -----------------------------------ieVIEQFLQNIkstigeye---------------------rdgev 747  Caenorhabditis e...
BAE60986   534 -------------------------------------KLQAALMDTgvpvdvpfpgkivrvdk--ddtadldntlrgaan 574  Aspergillus oryzae
EAS32029   638 tlqgydinwrdsgst------riripathradenryrQAFQQFKNMr--------------------------------- 678  Coccidioides imm...
EAT81814   630 lvkqygicagakavhtqklsslrdgathsaiktrlsdGIQTFVKNNkg-------------------------------- 677  Phaeosphaeria no...
EAT81938   659 lkvgnathlgt--------------hqlstnvkglqsGLRKAQQQKv--------------------------------- 691  Phaeosphaeria no...
EAT81940   568 systatiqcvgmc---------pdpqfdrgeaearisMEKAKDKGA---------------------------------- 604  Phaeosphaeria no...
EAT81960   768 ddiie--------------------------nildrgSVSAKISQAkae------------------------------- 790  Phaeosphaeria no...
EAT86396   644 dvaki--------------------------qqeimdTLRKKFKAKp--------------------------------- 664  Phaeosphaeria no...

Feature 1                                                                                      
NP_036286  514 glQLVVVILPGkt----------pVYAEVKRVGDtvlGMATQCVQMKNvqr-----------ttPQTLSNLCLKINVKLG 572  human
AAF06159   616 qkVLMFIIISKrq---------lnAYGFVKHYCDhtiGVANQHITSETvtkalas--lrhekgsKRIFYQIALKINAKLG 684  Caenorhabditis e...
17976540   748 ivPIVFAVFQAratvysgnnneynDYNVLKYLADnkyGIHTQGILEKSlgvvg------pspknCALTRLMVEKVLGKVG 821  Caenorhabditis e...
BAE60986   575 slDLLYIVLPKkd---------srWYLVIKRLCDveyGLQTICSVGPKlvakkgqtmeqydkslDQYMRNVAMKFNLKLG 645  Aspergillus oryzae
EAS32029   679 -tPYVIVLLPRfd---------qqVYSYVKYYGDivtGIPNTCVTEKYvkkekr----itfktdGGAVENIALKINLKLG 744  Coccidioides imm...
EAT81814   678 -tNLVVLLLKTqs---------ipVYSAFKAAADteaGLQSICMTQAPnyisakq---kckeniDQYMANIMMKANLKFG 744  Phaeosphaeria no...
EAT81938   692 --DLVILVLRSkd---------qeVYSNFKYLADrvfGIPSIVMVTASnfrgga----wnvtglDQYIGNIMMKANLKLG 756  Phaeosphaeria no...
EAT81940   605 --NFVMLFLEKen---------tpAYSVFKYLADcmyGMHSLCVVYKGkp------------fsPQYWGNIAMKMNLKAG 661  Phaeosphaeria no...
EAT81960   791 gaNLVVFLLNKss---------tpFYAHLKDLADrthGIHSLCLVEQYklikqyg---erahlfQEYMTNVVMKINLKMG 858  Phaeosphaeria no...
EAT86396   665 --NFLFVILPSdn---------avLYDCIKFVCDcklGVPNICNIGSKfske---------kgqMQYFANVAMKFNQKLG 724  Phaeosphaeria no...

Feature 1                                       # #                                            
NP_036286  573 GVNNILLpqgrp---------pvfqQPVIFLGADVTHppagd------gkkpSIAAVVGSMDAhpn----------ryCA 627  human
AAF06159   685 GINQELDwseiaeispeekerrktmPLTMYVGIDVTHptsys------gidySIAAVVASINPggtiyrnmivtqeecRP 758  Caenorhabditis e...
17976540   822 TTHRKLErggahktw---tiftdpaKPTLVLGIDVSHpstrdretgnvlqkmSAATVVGNIDLdvt----------efRA 888  Caenorhabditis e...
BAE60986   646 GTNHVVDnlrls---------iineDKTMIVGLDVTHptgssqv--ssatapSVAAMVASIDKtlg----------qwPA 704  Aspergillus oryzae
EAS32029   745 GINHEIQsdgri---------hdiiRTTMFIGIDVTHptgtds----qsgapSISAVVANNDPtla----------qwPA 801  Coccidioides imm...
EAT81814   745 GGNHTVQfaakplt-----hiattlQDTLVLGADITHpspgs-----lvgcpSIAAVVGSVNSmst----------kyLG 804  Phaeosphaeria no...
EAT81938   757 GINHSAEsdrgn--------iknhlENTLVLGSDVTHpsngs-----lfgcpSVAALVGSVDN---------------TG 808  Phaeosphaeria no...
EAT81940   662 GINHSVDgve------------qimKDTLVLGADCTHpesns-----lagtpSIAAIVGSVDAkgg----------kfLG 714  Phaeosphaeria no...
EAT81960   859 GITQSVTtvsd----------ylakNRVMVLGADVVHagpga-----ypgtpSIAAIVGSVDF---------------SA 908  Phaeosphaeria no...
EAT86396   725 GVNHTVElkrm----------apldPQTILFGIDVTHpspgs-----sdsapSVAGVVASVDSlfs----------qfPA 779  Phaeosphaeria no...

Feature 1                                                                 #                    
NP_036286  628 TVRVQQHRQEIIQd--------lAAMVRELLIQFYKSTrf----------kPTRIIFYRDGVSEGQFQQVLHHELLAIRE 689  human
AAF06159   759 GERAVAHGRERTDi--------lEAKFVKLLREFAENNdn---------raPAHIVVYRDGVSDSEMLRVSHDELRSLKS 821  Caenorhabditis e...
17976540   889 SSRIQDTGVECLId--------fSKEIDERIGEFIDHTgk----------rPAHIVVYRDGLSEGDFQKYLFEERVCIEE 950  Caenorhabditis e...
BAE60986   705 TIQVQSHGGKEEIds-------lDGMFKRHLRLWKLLGkha--------sfPENIIVFRDGISEGQYMKCLTEELPLMRK 769  Aspergillus oryzae
EAS32029   802 SITTQEHRKEMVEsv-------lERMVTDRLRAWKDQDk-----------lPARIIVYRDGVSESQYQEVLDTELVQIQS 863  Coccidioides imm...
EAT81814   805 SMRLQETCKKEIIdd-------lQAMVYERIVAYEQATrn----------fPKRILFYRDGVSTGQFAKVRDEELPSIKA 867  Phaeosphaeria no...
EAT81938   809 GCFLGSLRLQDQGs--------kESMVVDRLWDWFSLNkr---------khPKNILYYRDGVGDSQFEEVRNKELVDIRD 871  Phaeosphaeria no...
EAT81940   715 SMRLQPRLIACEDiq------dvESMVVERLMAWFMANkr---------tlPKNILYYRDGVSDTQYSQVKDRELPQIRK 779  Phaeosphaeria no...
EAT81960   909 GKCLGSMRLQRIDttdretivevEDMVRERLEAWAAARkaestdlgiteelPQSIIYYRDGVGTGQYETIKKIEVAAIRA 988  Phaeosphaeria no...
EAT86396   780 SMRTQRGRQEMVEe--------lEEMIVERLKLWQKRNgn---------klPNKVIVYRDGVSEGQYRIVLESEYPAFKK 842  Phaeosphaeria no...

Feature 1                                                                                      
NP_036286  690 ACIKLekd-------------yqPGITFIVVQKRHHTRLFCTdknervg------------------------------k 726  human
AAF06159   822 EVKQFmserd--------gedpePKYTFIVIQKRHNTRLLRRmekdkpvvnkdltpaetdvavaavkqweedmkesketg 893  Caenorhabditis e...
17976540   951 RCLKIdts-------------fqPSITYIVVTKRHHTQFFLEdpsqgyes-----------------------------q 988  Caenorhabditis e...
BAE60986   770 ACREIypkem--------heknlPKFTIIIVSKRHHTRFYPTegqtadk------------------------------- 810  Aspergillus oryzae
EAS32029   864 AVEQHyag------------rslPKITLLIVGKRHHTRFYPLnldaadk------------------------------- 900  Coccidioides imm...
EAT81814   868 AFRQRypivkg------rettplPRVTIVVAVKRHHTRFYPAkalkhl-------------------------------- 909  Phaeosphaeria no...
EAT81938   872 GYDQFvkevrkasfgrdiedpppLKLTAVVCTKRHHTRFYPNkpadmqtn-----------------------------a 922  Phaeosphaeria no...
EAT81940   780 AFAAFakklgl-------mqvpkFKLTAYVVAKRHHVRMFPLaadaapk------------------------------- 821  Phaeosphaeria no...
EAT81960   989 AYNKLatqyg---------lstdVKIHAVVVVKRHHTRFYPMnasegdkf-----------------------------g 1030 Phaeosphaeria no...
EAT86396   843 AFDRLygae-----------knhPKISIVVVGKRHHTRFYPTkeedtdg------------------------------k 881  Phaeosphaeria no...

Feature 1                                                                                      
NP_036286  727 sgnipaGTTVDTkITHPTEFDFYLCSHagiqGTSRPSHYHVLWDDNRFs-------------sDELQILTYQLCHTYVRC 793  human
AAF06159   894 ivnpssGTTVDKlIVSKYKFDFFLASHhgvlGTSRPGHYTVMYDDKGMs-------------qDEVYKMTYGLAFLSARC 960  Caenorhabditis e...
17976540   989 gynvlpGTLIEDaVTTNKYYDFFLSTQigneGCFRPTHYYVLHDTWTGkp------------dSFWPTVTHALTYNFCRS 1056 Caenorhabditis e...
BAE60986   811 ngntppCTIVDRsITDPHCFSFFLQPHsaihGTARNAFYFVILDEVFSqrytgklrpkyknvaEIVQDLTLNLSYLVGRA 890  Aspergillus oryzae
EAS32029   901 kgnvtpGTVVDRyCTMERNFDFFMVSHagiqGTSRPAHYVVLHDSNNFt-------------aDQLQSITHDLTWVYGRA 967  Coccidioides imm...
EAT81814   910 ngncvpGTLVDRvVTSPHYCDFFLQSHhglkGTAIPTHYVVIANEIGLg-------------dKELQELTWKMCYTYVRA 976  Phaeosphaeria no...
EAT81938   923 qnnckaGTLVEQsVTNPYFTDFYLQSHngikGTAKPAHYFVLVNEMEIg-------------vSDLQHLTYNLCLSYVRA 989  Phaeosphaeria no...
EAT81940   822 ngncrpGTVVDSgITSPYFGDFYMQSHngliGTARSAHYFPLVNEMGLt-------------dVQIQLFTHRLCYTYVRA 888  Phaeosphaeria no...
EAT81960  1031 nentlpGTFVDRlVTSPYYQDFYLQSHsgikGTVKPTHYFVLEAEIPGlt------------lDKLRDLTHQICYSYARA 1098 Phaeosphaeria no...
EAT86396   882 tgnpqpGTVVDRgVTGEKLFDFFLLAHqglqGTSKPAHYVVLKDDIKLg-------------aDQLQSLTHSLCYTFARA 948  Phaeosphaeria no...

Feature 1                   #          
NP_036286  794 TRSVSIPAPAYYAHLVAFRARYHL 817  human
AAF06159   961 RKPISLPVPVHYAHLSCEKAKELY 984  Caenorhabditis elegans
17976540  1057 TTTVALPAPVLYAHLAAKRAKETL 1080 Caenorhabditis elegans
BAE60986   891 TKGVRVCCPARYADLVCDRARCYL 914  Aspergillus oryzae
EAS32029   968 ARSVSIATPAYYADIVCERGRCYL 991  Coccidioides immitis RS
EAT81814   977 TLGVSYAPPAYYSDRLCDRGRAYM 1000 Phaeosphaeria nodorum SN15
EAT81938   990 TMGVSYAAPAYYADRLCERARCYL 1013 Phaeosphaeria nodorum SN15
EAT81940   889 SMGVSYAPPAFYADRLCDRGRCYL 912  Phaeosphaeria nodorum SN15
EAT81960  1099 LCAVSYASPTFYADRLCDRGRTYI 1122 Phaeosphaeria nodorum SN15
EAT86396   949 TRSVSICPPAYYADLLCERGRCYL 972  Phaeosphaeria nodorum SN15

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