2J6X


Conserved Protein Domain Family
LOX_like_FMN
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cd04737: LOX_like_FMN 
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L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO).
Links
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Statistics
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PSSM-Id: 240088
Aligned: 7 rows
Threshold Bit Score: 501.972
Created: 22-Jan-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on homology to other members of the subfamily
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #                                                  
2J6X_A     15 KYIDVVNt----YDLEEEASKvvphGGFNYIAGASgDEWTKRANDRAWkhkLLYPRLAqd--vEAPDTSTEILGHKIKaP 88  Aerococcus viridans
NP_345216  10 GHVDFINt----YDLEPMAQQvipkAAFGYIASGAeDTFTLRENIRAFnhkLIVPHTLcn--vENPSTEIEFAGEKLSsP 83  Streptococcus pneu...
NP_267408  27 KALEIVNvksleGKVKQSMEAagnkGGFGYIRGGSeDEWTLNENTSAFnkkQIMPRVLrg--iDSADLSTSLFGIKLKtP 104 Lactococcus lactis...
CAD33731   52 KSLHIISl----DRLEASAKDvmteAAYAYIAHGAgDEWTYHENRRAFsdyPLLPHRLsgvaaHSIDIRTDLLGHHLEhP 127 Escherichia coli
AAL20538   34 KAIKMTNv----ASLEARVQAkmekGAFGYIRGGAeDENNLRSNTESFdkkYIMPRVLqgielKEIDLSTQLLGIPLKtP 109 Salmonella typhimu...
CAE16743   12 KSLDIINl----YDLEEEARKliptPQFDYISGGSgDEWTLRENTRAFddfQIIPRYLag--vKEPDTTTELLGSNVDmP 85  Photorhabdus lumin...
CAC51461   14 QKLTILNl----PSLEAAAKKiipsGGFGYISGGSeDEWTLKQNTMAFnhvQIVPRALtd--mEQPSTQTQAFGIDLKtP 87  Lactobacillus plan...

Feature 1                                      #                       #                      
2J6X_A     89 FIMAPIAAHGLAHTTKEAGTARAVSeFGTIMSISAYsgaTFEEISEGlngGPRWFQIYMakDDQQNRDILDEAKSDGaTA 168 Aerococcus viridans
NP_345216  84 IIMAPVAAHKLANEQGEVATARGVHeFGSLYTTSSYstvDLPEISEAlqgTPHWFQFYFskDDGINRHIMDRVKAEGyKA 163 Streptococcus pneu...
NP_267408 105 IIQAPVAAQGLAHAEGEVATAKAMAeVGSIFSISTYgstSVEDAAKAapdAPQFFQLYMskDDKFNEFLLKKAVSAGvKA 184 Lactococcus lactis...
CAD33731  128 LLIAPMGAHMFVHPEGEVIAAAGAEkAGALYESSGAsnrSLEDIAKAs-kGPKWFQLYFnaDAGVTRSLLERAKAAGySA 206 Escherichia coli
AAL20538  110 IIQAPMAAQGLAHASGELATAKGMAqVGSIFSLSTYgnkTIEEVANVsgkNPFFFQLYMskNNQFNEFILAQAVKHGaKA 189 Salmonella typhimu...
CAE16743   86 IFIPPIAAHGLAHTTAELGTARGAAsAGTLFTAQTLsnsSLEEIAKVs-nGPKWFQIYLtkDMGINRELIRRAKAMGaTA 164 Photorhabdus lumin...
CAC51461   88 IMMAPAAAQGLAHARGEAATAEGMAqVGALMAQSTYsstSIADTAAAgkgAPQFFQLYMskDWDFNQSLLDEAVKAGaKA 167 Lactobacillus plan...

Feature 1          #      #                                                                 # 
2J6X_A    169 IILTADSTvSGNRDRDvKNKFVYPFGMPivqryl------rgtaeGMSLNNIygaskqkISPRDIEEIAAhsGLPVFVKG 242 Aerococcus viridans
NP_345216 164 IVLTADATvGGNREVDkRNGFVFPVGMPiveey-------lpegaGKSMDFVyksakqrLSPRDVEFIAEysGLPVYVKG 236 Streptococcus pneu...
NP_267408 185 IILTADSTlGGYREEDiVNHFQFPFPMPnlaafs------esdgtGKGISEIyaaakqgLVLEDIQKIKKitNLPVIVKG 258 Lactococcus lactis...
CAD33731  207 IIITADALgPGTSDAFlSMSSPFPAGATfgnhd--------prygGKGDFFNqk---veLTPADIEFVKKitGLPVIVKG 275 Escherichia coli
AAL20538  190 IILTVDSPvGGYREEDiKNNFQFPLGFAnlemfarknddgsktgkGAGISEIyaqakqaFTPEDIAYVHRisGLPVIVKG 269 Salmonella typhimu...
CAE16743  165 IVFTVDLEwSGNREADkRNKFIFPHSLPfpnip--------gapvGATLSEItelfkrdLNFSDLEFLAKesGLPIIVKG 236 Photorhabdus lumin...
CAC51461  168 IILTVDATvDGYREDDiINNFQFPIPMAnltkfs------egdgkGKGIMEIyaaaaqkISPADVRRITEytNLPVIVKG 241 Lactobacillus plan...

Feature 1                           #  #                                                   #  
2J6X_A    243 IQHPEDADMAIKAGaSGIWVSNHGARQLYEAPGSFDTLPAIAERVNkrVPIVFDSGVRRGEHVAKALASGADVVALGRPV 322 Aerococcus viridans
NP_345216 237 PQCREDVERSLAAGaSGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDrrVPIVFDSGVRRGQHVFKALASGADLVAIGRPV 316 Streptococcus pneu...
NP_267408 259 VQSPIDADDAINAGaDGIWVSNHGGRQLDGGPASIDVLPLIAKSVNhrVPIVFDSGVRRGEHVFKALAQGADVVAVGRPV 338 Lactococcus lactis...
CAD33731  276 ILRGEDAVVAIDAGaDAIQVSNHGGRQIDGVPSAISQLQEVAARVGhkVPVIFDSGIRRGIDVVRAISLGATAVAVGRPV 355 Escherichia coli
AAL20538  270 IQSPEDAEIAIQAGaAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNkrVPVIFDSGVRRGSHIFKALASGADIVAVGRPV 349 Salmonella typhimu...
CAE16743  237 IQSAENAKECVNHGaAAIQVSNHGGRQLDTVPAAIASLPHIVEAVGskIPVYLDGGIRRGTHVFKALALGAKAVAIGRPI 316 Photorhabdus lumin...
CAC51461  242 IQSPEDALLAIGAGaQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNgrVPIIFDSGVRRGSHVFKALANGADLVALARPI 321 Lactobacillus plan...

Feature 1                                                
2J6X_A    323 LFGLAlGGWQGAYSVLDYFQKDLTRVMQLTGSqnVEDLKGLDL 365 Aerococcus viridans
NP_345216 317 IYGLAlGGSVGVRQVFEHLNAELKTVMQLSGTqtIEDVKHFKL 359 Streptococcus pneumoniae TIGR4
NP_267408 339 LYGLNlGGAKGVQSVFEHLNKELSITMQLAGTknIEEIKHTSL 381 Lactococcus lactis subsp. lactis Il1403
CAD33731  356 LYGIAaGGVGGVASVIEHLKTELRTAMLLSGArtLKDLSQGFI 398 Escherichia coli
AAL20538  350 LYGLNlGGAQGVASVIEQLNKELTINMMLGGArnIEQVKTTRL 392 Salmonella typhimurium LT2
CAE16743  317 LYALAlGGAPGVTSILNLLKDELKLSMKLAGCaaIKDIERKFI 359 Photorhabdus luminescens subsp. laumondii TTO1
CAC51461  322 IYGLAlGGAQGVASVVSHLNDELLIDMQLAGTktIEDVKRAKL 364 Lactobacillus plantarum

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