1BYY


Conserved Protein Domain Family
Na_channel_gate

?
cd13433: Na_channel_gate 
Click on image for an interactive view with Cn3D
Inactivation gate of the voltage-gated sodium channel alpha subunits
This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Links
?
Statistics
?
PSSM-Id: 240441
View PSSM: cd13433
Aligned: 72 rows
Threshold Bit Score: 54.8784
Threshold Setting Gi: 365812021
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic latch
Evidence:
  • Comment:Might be involved in fast closing of the sodium channel, occluding the pore via a hinged-lid mechanism
  • Citation:PMID 9893979

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       ####                                   
1BYY_A       1 DNFNQQKKKFGg---qDIFMTEEQKKYYNAMKKLGSKkpqKPIPRPANKFQGMVFD 53   Norway rat
AEW90239  1504 DNFYRLKKQYDdcgtvEVFLTTEQKQWFSTVKKALTKkpkHIIHRPKNFYQAKLFD 1559 Clytia hemisphaerica
EDO46797  1052 DNFNTLKKKYEeinsmGMLLTESQRKWVQILMAAAKRkppSNRLRPTDCFRGKLFD 1107 starlet sea anemone
AEX00072  1143 DNFNTLKRKYDelsgmGMLLTERQRKWVDMLKEAAKTrtpSQAIRPNDIIRGCIFD 1198 starlet sea anemone
AEW90237  1137 DNFYRLKKQFDgcktvEVNLSALQKQWFLSVKNALSKksnRLLQRPKGCYFSKLFD 1192 green hydra
CCA18882  1290 DNFNRMKAALGg----DFMLTPEQKKWIEAQKAALRIgpvRLVKVPKNKYRKWIHT 1341 Albugo laibachii Nc14
EGZ10921  1221 DNFNRMKAALGg----DFMLTPEQKKWVEAQKAASRVgpvRILKPPRQMWRRYIFF 1272 Phytophthora sojae
AEF59076  1028 DTFNRLKAELKeg--rNLFLTEGQQQFITQLQSALRAkpkRRYERPQRRWRGWCYD 1081 Monosiga brevicollis
EGZ10885  1061 DNFNTMKAKLGg----DFLLTPEQKKWMEAQKSATRIgpiRILKPPPLSVRRLCFT 1112 Phytophthora sojae
EGZ10886   874 ENFNTMKAKLGg----DFLLTPEQKKWMEAQKSATRIgpiRMVNAPTQVLRRVCFS 925  Phytophthora sojae

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap