1PNU,1VS6,3BBO,2J01,1NKW,2FTC,1FFK,4A17,2ZKR,3IZR,2WW9


Conserved Protein Domain Family
KOW_RPL26

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cd06089: KOW_RPL26 
Click on image for an interactive view with Cn3D
KOW motif of Ribosomal Protein L26
RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.
Statistics
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PSSM-Id: 240513
Aligned: 308 rows
Threshold Bit Score: 34.0274
Created: 4-Oct-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ###           #              ##                     ##    
1PNU_S        18 GDTVIVLSGKHkGQTGKVLLALPrdQKVVVEGVNVITKnvkpsmtnpqggqEQRELALHASKVAL 82  Escherichia coli
EGZ13178      31 GDKVEIIAGPHkGTQGEVVSVARdlNKVIVENVNMSHRyvkatp-aasgrsYLSPSPIHYSNVNL 94  Phytophthora sojae
EFD92289      57 GDSVIITRGKFkGKEGKIDKVYTkqLKVSVDSAKNVTKk-----------gNKVPFKIRPSALII 110 Candidatus Parvarchaeum acidop...
CBH28910      52 QDKVTVMAGKFkKLQGVVTAVRRkeYKVYVDSCENTLSn-----------gKKQPVGIDASNLRI 105 Anncaliia algerae
XP_001712404  52 EDEILVVRGLHkGEIGKVVQCQRkiFKILIDKINRMKSn-----------kTNVFIPISPSNVVI 105 Hemiselmis andersenii
XP_001713536  52 NYEIKVKRGDFkGKTGKVIQIKPeqQKIFVDNIFRNKFe-----------kTNIFVPLKPSNIQI 105 Guillardia theta
NP_597166     53 GDTVVVKGGKFdGKEGVISKINYrdYKVYIEGCFVTKNd-----------gTNALVPIYPSKLTI 106 Encephalitozoon cuniculi GB-M1
EHY66253     120 GDEVLVLKGDLkGKTGKIVKVNRatFKVVLDISYREKKn-----------gQTASFGIYPSSLVI 173 Nematocida sp. 1 ERTm2
EFW41814      57 GDKVQIVGGPHiGQRGEVVSIYRrsGRITVAGVNMVNRtlkte---aigvpMKMPSPILYKHVNV 118 Capsaspora owczarzaki ATCC 30864
ADZ95715      53 KDIVKVHSGPYkGKEGQVLEVIPkeYRITVEGCIETGEke----------eETKNALIHPSCVTI 107 Nosema bombycis

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