Conserved Protein Domain Family
RRM2_RBM45

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cd12367: RRM2_RBM45 (this model, PSSM-Id:240813 is obsolete and has been replaced by 409802)
RNA recognition motif 2 in RNA-binding protein 45 (RBM45) and similar proteins
This subfamily corresponds to the RRM2 of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a new member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which expresses under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis. RBM45 carries four RRMs, also known as RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
Statistics
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PSSM-Id: 240813
Aligned: 10 rows
Threshold Bit Score: 141.382
Created: 18-Nov-2011
Updated: 1-Feb-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IUH3       120 LTRIFVMIPKsyTEEDLREKFKvYGDIEYCSIIKNKvTGESKGLGYVRYLKpSQAAQAIENCDrsFRAILAEPK 193 human
NP_001080090 113 LTRIFVMIPKsyTEEDVKQKFKeYGQIEYCSIIKNKnTGESKGLAYVRFLKpSQAALAIENCDrsFKAILAEPK 186 African clawed frog
NP_001120874 110 LTRIFVMIPKtfTEDDLKETFKvYGDIEYAIIIRNKtTGDSKGLGYVRFHKpSQAAKAVENCDktFRAIIAEPR 183 zebrafish
NP_001026423 147 LTRIFVMIPKtyTEEDLREKFKmYGDIEYCSIIKNKtTGESKGLGYVMYLKpSQAARAIEECDrsYRAILAEPK 220 chicken
NP_647887    122 YVRLFIVIPKtaTEEDIREEFSqWGDVESVTIVKEKnNGNPKGFGYVRFTKfYYAAVAFENCSakYKAVFAEPK 195 fruit fly
XP_002586890  32 LTRLFLVIPKslEEEDLKDIFKeWGPIEYVNVVRDRgSGDPKGFGYVKYYKaSHAALALENCDktYKPVFAEPR 105 Florida lancelet
XP_002110714 101 RARLFVVCPRdyTEEDLKEKFVeFGSIDYCQIVKDHtTKKSKGLGYVKFNKaSAAAIALENCDasFRAVLAEPK 174 Trichoplax adhaerens
XP_003382631 162 RTRLFVVCPKeySEQDLKAKFEhFGDFDFCNIIRDKhTGENKGFGYVKFTRaSTAAVAMENCDkaFKAVLAEPK 235 Amphimedon queenslandica
XP_001635913 112 MTRLFVICPKdfNDEDLRSKFEsFGDIEYVQIVRDHkTRENKGYGYVKFHKsSTAAMALENCDksLKAVWAEPK 185 starlet sea anemone
EFX90035     122 LLRLFVVVPKsmNDSELRDHFAqFGDIDYVSIVKDKnTKESKGFAYVKYHRvSHTAKAFECCErsFKPVFADPR 195 common water flea
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