1PMI_A 5 LFRIQCGYQNYDWGkigSSSAVAQFVHNS---DPSiti-deTKPYAELWMG-THPSVPSKaiDLNNQt----LRDLVTAK 75 Candida albicans P00946 1 MQKLINSVQNYAWG---SKTALTELYGME---NPS------SQPMAELWMG-AHPKSSSR--VQNAAgdivsLRDVIESD 65 Escherichia coli K-12 P29952 5 LFRLDAGYQQYDWGkigSSSAVAQFAAHS---DPSvqi-eqDKPYAELWMG-THSKMPSY--NHESKe---sLRDIISKN 74 Saccharomyces cerevis... P29951 5 LLRLQCGVNSYDWGrvgPESAAAKYAAAT---APSdftieaDKPYAELWMG-THPSLPSK--DVETQr---tLLDMVQDN 75 Aspergillus nidulans ... P34650 2 LLKLKCTVNNYAWGpk-gNSSMAGSLALDgghIPNld---kDKPYAEFWVG-THANGPAH--VIEKD--------IALKQ 66 Caenorhabditis elegans Q59935 5 LF-LQSQMHKKIWGg----NRLRKEFGYD---IPS-------ETTGEYWAIsAHPNGVSV--VKNGV-----YKGVPLDE 62 Streptococcus mutans ... 1QWR_B 9 IF-LTPVFKEKIWGg----TALRDRFGYS---IPS-------ESTGECWAIsAHPKGPST--VANGP-----YKGKTLIE 66 Bacillus subtilis P34949 6 VFPLSCAVQQYAWGkmgSNSEVARLLASS---DPLaqi-aeDKPYAELWMG-THPRGDAK--ILDNR-----ISQKTLSQ 73 human
1PMI_A 76 pQEYLGESII----TKF--GSskeLPFLFKVLSIEKVLSIQAHPDKKLGAQ----------LHAADPKNYPDDNHKPEMA 139 Candida albicans P00946 66 kSTLLGEAVA----KRF--GE---LPFLFKVLCAAQPLSIQVHPNKHNSEIgfakenaagiPMDAAERNYKDPNHKPELV 136 Escherichia coli K-12 P29952 75 pSAMLGKDII----DKFhaTNe--LPFLFKVLSIEKVLSIQAHPDKALGKI----------LHAQDPKNYPDDNHKPEMA 138 Saccharomyces cerevis... P29951 76 -LALMSPEVS----ERY--GGk--LPFLFKVLSIRKALSIQAHPNKKLAEA----------LHARDPRNYPDDNHKPEMT 136 Aspergillus nidulans ... P34650 67 lLATSPELQG----KHE--KGn--LSFLFKVLSVLGPLSIQIHPTKEQGKL----------LHATDPKNYPDDNHKPEIA 128 Caenorhabditis elegans Q59935 63 lYAEHRELFG----NSK--SSv--FPLLTKILDANDWLSVQVHPD----------------------NAYALE-HEGELG 111 Streptococcus mutans ... 1QWR_B 67 lWEEHREVFG----GVE--GDr--FPLLTKLLDVKEDTSIKVHPD----------------------DYYAGENEEGELG 116 Bacillus subtilis P34949 74 wIAENQDSLGskvkDTF--NGn--LPFLFKVLSVETPLSIQAHPNKELAEK----------LHLQAPQHYPDANHKPEMA 139 human
1PMI_A 140 IAVTDFEGFCGFKpldqlaktLAtvPELNEIIGQELVDEFISGIKLPAevgsQDDVNnr-klLQKVFGKLMNTDDDVIKQ 218 Candida albicans P00946 137 FALTPFLAMNAFR--------EF--SEIVSLLQPVAGAHPAIAHFLQQ----PDAER-----LSELFASLLNMQGEEKSR 197 Escherichia coli K-12 P29952 139 IAVTDFEGFCGFKplqeiadeLKriPELRNIVGEETSRNFIENIQPSAqkgsPEDEQnk-klLQAVFSRVMNASDDKIKI 217 Saccharomyces cerevis... P29951 137 IAITPFEGLCGFRplaeivhfLKavAPLRYLIGVQTATDFENAVRGFEntedPEQTKknkvaLRTLFTSLMQSASENIEQ 216 Aspergillus nidulans ... P34650 129 IALTEFELLSGFRqhsqiseyLKlySEIQELLTEEEKSQIDSLGSYGE-----SSAQv----LKKIFSRIWRTPKEKLQI 199 Caenorhabditis elegans Q59935 112 ------KTECWY---------VIsaDEGAEIIYGHEAKSKEELRQMIAag-dWDHLLtkipvKAGDF-FYVPSGTMHAIG 174 Streptococcus mutans ... 1QWR_B 117 ------KTECWY---------IIdcKENAEIIYGHTARSKTELVTXINsg-dWEGLLrrikiKPGDF-YYVPSGTLHALC 179 Bacillus subtilis P34949 140 IALTPFQGLCGFRpveeivtfLKkvPEFQFLIGDEAATHLKQTMSHDS-----QAVAs---sLQSCFSHLMKSEKKVVVE 211 human
1PMI_A 219 QTAKLLERTDREP----QVFKDIdsrl------pelIQRLNKQFPNDIGLFCgcLLLNHVGLNKGEAMFLQ--------- 279 Candida albicans P00946 198 ALAILKSALDSQQ----GEPWQT-------------IRLISEFYPEDSGLFSp-LLLNVVKLNPGEAMFLF--------- 250 Escherichia coli K-12 P29952 218 QARSLVERSKNSP----SDFNKPdlp--------elIQRLNKQFPDDVGLFCgcLLLNHCRLNAGEAIFLR--------- 276 Saccharomyces cerevis... P29951 217 AARELVAAAQSSPetfaSLVNAPdtnptnaaelasiIIRLNEQFPNDIGLFVf-FFLNFVRLEPGEAMFLK--------- 286 Aspergillus nidulans ... P34650 200 VVDKLARRIQGHE-------NKTald--------eiIVYLFTLYPGDVGVFAp-IFLNYFKLQPGEATFLE--------- 254 Caenorhabditis elegans Q59935 175 KGIMILETQQSSD----TTYRVYd------------FDRK-----DDQGRKR--------AL-----HIEQsidvltigk 220 Streptococcus mutans ... 1QWR_B 180 KGALVLETQQNSD----ATYRVYd------------YDRL-----DSNGSPR--------EL-----HFAK--------- 216 Bacillus subtilis P34949 212 QLNLLVKRISQQAa---AGNNMEdif-------gelLLQLHQQYPGDIGCFAi-YFLNLLTLKPGEAMFLE--------- 271 human
1PMI_A 280 -AKDPHAYISGDIIECMAASDNVVRAGFTPKFKDVKNLVEMLTYSYESV---EKQKMP---LQEfprskgDAv------k 346 Candida albicans P00946 251 -AETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPA---NQLLTQ---PVK------QG-------- 309 Escherichia coli K-12 P29952 277 -AKDPHAYISGDIMECMAASDNVVRAGFTPKFKDVKNLVSMLTYTYDPV---EKQKMQ---PLKf----dRSsgn---gk 342 Saccharomyces cerevis... P29951 287 -ADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLTEMLTYSYAPI---DEQKLQ---PTDypytvlNAaayssasd 359 Aspergillus nidulans ... P34650 255 -PNMPHAYLKGDCVECMADSDNTIRAGLTPKYIDVESLVEMLNY--------DETLLP---KYIpne-ldDG-------- 313 Caenorhabditis elegans Q59935 221 pANATPAWLS---LQGL---ETTV--------LVSSPFFT--VYKWQIS---GSVKMQ---QTApy---lLV-------- 267 Streptococcus mutans ... 1QWR_B 217 -AVNAATVPH---VDGYIDESTESRKGITIKTFVQGEYFS--VYKWDIN---GEAEXA---QDEsf---lIC-------- 273 Bacillus subtilis P34949 272 -ANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSY--TPSsskDRLFLPtrsQEDpy---lSI-------- 337 human
1PMI_A 347 SVLYDP-PIAEFSVLQTifdKSK--GGKQVIEGLn-GPSIVIATNGKGTIQITGD 397 Candida albicans P00946 310 AELDFPiPVDDFAFSLH---DLS--DKETTISQQ--SAAILFCVEGDATLWKGSQ 357 Escherichia coli K-12 P29952 343 SVLYNP-PIEEFAVLET---TFDekLGQRHFEGVd-GPSILITTKGNGYIKADGQ 392 Saccharomyces cerevisiae S288c P29951 360 SLLYDP-PIEEFSVVKT---SLRrtGAKATFDPLt-GPSILICTGGTGKISVGHK 409 Aspergillus nidulans FGSC A4 P34650 314 SLLFTPrGIDEFWVQEV---KGP--AGSIYQLPYseSCSVLTVLYGTATVTLGDA 363 Caenorhabditis elegans Q59935 268 SVLAGQ-GRITVGLEQY---ALR--KGDHLILPNt-IKSWQFD--GDLEIIASHS 313 Streptococcus mutans UA159 1QWR_B 274 SVIEGS-GLLKYEDKTC---PLK--KGDHFILPAq-XPDFTIK--GTCTLIVSHI 319 Bacillus subtilis P34949 338 ---YDP-PVPDFTIMKT---EVPgsVTEYKVLALd-SASILLMVQGT--VIASTP 382 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",