3VBC


Conserved Protein Domain Family
SEFIR
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pfam08357: SEFIR 
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SEFIR domain
This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.
Links
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Statistics
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PSSM-Id: 254756
Aligned: 16 rows
Threshold Bit Score: 99.7772
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3VBC_A   5 IKVLVVYPS-EICFH-HTVCRFTDFLQNYC--RSEVILEAWQAAAIAEMGPVQWLTTQ----KQAADKVVFLLPSDVPTL 76 
Q60943 380 RKVWIVYSA-DHPLYvEVVLKFAQFLITAC--GTEVALDLLEEQVISEVGVMTWVSRQkqemVESNSKIIILCSRGTQAK 456 house mouse
Q69HQ3 391 SNLFLVYWD-DHKLHrDVVLKLASYLQHL---GFNVFCELFEQNEIFA-DRCDWMEKR----MSQAEKVVIVWSAGAIDI 461 vase tunicate
Q10128 415 VKVMIVYAD-DNDLHtDCVKKLVENLRNCA--SCDPVFDLEKLITAEQIVPSRWLVDQ----ISSLKKFIIVVSDCAEKI 487 Caenorhabditis elegans
Q6AZ51 448 RPVLLLHAA-DSEAQrRLVGALAELLRTALggGRDVIVDLWEGTHVARIGPLPWLWAArervAREQGTVLLLWS------ 520 Norway rat
Q8NAC3 584 RAALLLYSAdDSGFE-RLVGALASALCQL---PLRVAVDLWSRRELSAQGPVAWFHAQrrqtLQEGGVVVLLFSPGAVAL 659 human
Q8BPI5 107 RTALLLHSA-DGAGYeRLVGALASALSQM---PLRVAVDLWSRRELSAHGALAWFHHQrrriLQEGGVVILLFSPAAVAQ 182 house mouse
O43734 410 RKVFITYSM-DTAME---VVKFVNFLLVN---GFQTAIDIFED-RIRGIDIIKWMERY----LRDKTVMIIVAI-SPKYK 476 human
Q8VUX6   2 KKIFISYAW-DEIED-EKVIKLAEMLEDYK--EFEVSFDKWDINK--GQEVPLFMERG----IQQSDFVLIICS----ER 67  Staphylococcus hominis
Q7UT52  13 RKVFVSYAH-TSEPHiEWILAFVADLQAN---GIEVVVDQYDL----KEGQDANTFMEkvvtDKTIDRVLIVSD----EN 80  Pirellula sp.

3VBC_A  77 CDSACGHNEGSARENSQ------------DLFPLAFNLF---CSDFSS--QTHLHKYLVVYL-GGADLKGDYNALSV--C 136
Q60943 457 WKAILGWAEPAVQLRCDhwk------pagDLFTAAMNMI---LPDFKR--PACFGTYVVCYFsGICSERDVPDLFNI--T 523 house mouse
Q69HQ3 462 WKKCQNQQDAFEVTNs-------------DFFTPVVKKIkndLIK-----ESNLRKYCFVYF-GYVKMKEIPTIFRElsG 522 vase tunicate
Q10128 488 LDTEASETHQLVQARPFa-----------DLFGPAMEMI---IRDATHnfPEARKKYAVVRF---NYSPHVPPNLAIlnL 550 Caenorhabditis elegans
Q6AZ51 521 CAGPSTACSGDPQTASL----------------RTLSCA-------------APRQLLLAYFsRLCAKGDIPGPLRA--L 569 Norway rat
Q8NAC3 660 CSEWLQDGVSGPGAHGPh-----------DAFRASLSCV---LPDFLQ--GRAPGSYVGACFdRLLHPDAVPALFRT--V 721 human
Q8BPI5 183 CQQWLQLQTVEPGPh--------------DALAAWLSCV---LPDFLQ--GRATGRYVGVYFdGLLHPDSVPSPFRV--A 241 house mouse
O43734 477 QDVEGAESQLDEDEHGLh-----------TKYIHRMMQI-----EFIKqgSMNF-RFIPVLF-PNAKKEHVPTWLQN--T 536 human
Q8VUX6  68 YKVNADKRRGGSGYEAR--------------LMSDEVLR-----------NEDKDRFIPIIL-NEKDKKNIPNFLKS--- 118 Staphylococcus hominis
Q7UT52  81 YAAKADGRKGGVGTESQiitqklykdieeTRFIPILKER-------DDqgNACLPVFLGGRI-----------------Y 136 Pirellula sp.

3VBC_A 137 PQYHLMKDATAFHTEL 152
Q60943 524 SRYPLMDRFEEVYFRI 539 house mouse
Q69HQ3 523 CHFQLMKQFQEFYFQL 538 vase tunicate
Q10128 551 PTFILPEQFAQLTAFL 566 Caenorhabditis elegans
Q6AZ51 570 PRYRLLRDLPRLLRAL 585 Norway rat
Q8NAC3 722 PVFTLPSQLPDFLGAL 737 human
Q8BPI5 242 PLFSLPSQLPAFLDAL 257 house mouse
O43734 537 HVYSWPKNKKNILLRL 552 human
Q8VUX6 119 ----------KLWTEL 124 Staphylococcus hominis
Q7UT52 137 IDFSNPDAYATRLEEL 152 Pirellula sp.
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