2OCC,1EHK,1FFT,2YEV,2IWF


Conserved Protein Domain Family
CuRO_HCO_II_like

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cd13842: CuRO_HCO_II_like 
Click on image for an interactive view with Cn3D
Cupredoxin domain of Heme-copper oxidase subunit II
Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is diverse in terms of electron donors, subunit composition, and heme types. The number of subunits varies from two to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian cytochrome c oxidase (CcO) are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. It has been proposed that archaea acquired heme-copper oxidases through gene transfer from gram-positive bacteria. Subunit II is found in CcO, ubiquinol oxidase, and the ba3-like oxidases, while the cbb3 oxidases contain alternative additional subunits. Additionally, nitrous oxide reductase contains the globular portion of subunit II as a domain within its structure. In some families, subunit II contains a copper-copper binuclear center that is involved in the transfer of electrons from the substrate to the binuclear center (active site) in subunit I.
Statistics
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PSSM-Id: 259911
Aligned: 22 rows
Threshold Bit Score: 86.9665
Threshold Setting Gi: 15920313
Created: 8-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
CuA binuclear
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: CuA binuclear center [ion binding site], 5 residue positions
Conserved feature residue pattern:H C C H MClick to see conserved feature residue pattern help
Evidence:
  • Structure:2YEV; Thermus thermophilus Caa3-Type Cytochrome Oxidase binds 2 Coppers at the CuA center.
    View structure with Cn3D
  • Structure:2IWF; Achromobacter cycloclastes Nitrous Oxide Reductase binds to coppers at CuA site.
    View structure with Cn3D
  • Comment:Electron transfer is believed to proceed from CuA via heme a to the binuclear center

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                           #         
2OCC_B     95 LTVKTMGHQWYWsyeytdyedlsfdsymiptselkpgelrllevdnRVVLPMemTIRMLVSSEDv----LHSWAVPs--- 167 cow
1EHK_B     79 YTVYVLAFAFGYqp-------------------------------nPIEVPQgaEIVFKITSPDv----IHGFHVEg--- 120 Thermus thermophilus
2YEV_E    117 MKVEVTGYQFWWdfhypel---------------------glrnsnELVLPAgvPVELEITSKDv----IHSFWVPg--- 168 Thermus thermophil...
2IWF_A    546 VRVYMTSVAPSFsq-------------------------------pSFTVKEgdEVTVIVTNLDeiddlTHGFTMGn--- 591 Achromobacter cycl...
NP_378395  58 IVIYMLGVQWAWepmnateiiylpngtme-nisvtstvityvngfpAIKVEPgqPILLVLYSNNv----MHAFYLRlp-- 130 Sulfolobus tokodai...
NP_375982  80 LVVNMTITQQNGfq------------------------------pdLIIANTsePVVIILNSPQv----ITGFYLRlp-- 123 Sulfolobus tokodai...
BAA82096   91 SDVYMMARLWEWy--------------------------------pVLELEKgkSYRLHLSSLDw----QHGFSVQp--- 131 Magnetospirillum m...
BAJ49683   41 LTVKVVARQFAWqfvypd-----------------------gtvsgELRVKAgqTVRLELNSEDv----IHSFYLRd--- 90  uncultured crenarc...
YP_344943  81 QQVDVSGHQWYWtm-------------------------------sTDTVVAgkPVEFRVIGADv----NHGFGVYnedl 125 Nitrosococcus ocea...
AAU91543   74 LQVRLVAGRYGFyp-------------------------------rEIEVPAgrRIVFRMASMDv----LHGAHIPm--- 115 Methylococcus caps...
1EHK_B     79 YTVYVLAFAFGYqp-------------------------------nPIEVPQgaEIVFKITSPDv----IHGFHVEg--- 120 Thermus thermophilus
2YEV_E    117 MKVEVTGYQFWWdfhypel---------------------glrnsnELVLPAgvPVELEITSKDv----IHSFWVPg--- 168 Thermus thermophil...
2IWF_A    546 VRVYMTSVAPSFsq-------------------------------pSFTVKEgdEVTVIVTNLDeiddlTHGFTMGn--- 591 Achromobacter cycl...
NP_378395  58 IVIYMLGVQWAWepmnateiiylpngtme-nisvtstvityvngfpAIKVEPgqPILLVLYSNNv----MHAFYLRlp-- 130 Sulfolobus tokodai...
NP_375982  80 LVVNMTITQQNGfq------------------------------pdLIIANTsePVVIILNSPQv----ITGFYLRlp-- 123 Sulfolobus tokodai...
BAA82096   91 SDVYMMARLWEWy--------------------------------pVLELEKgkSYRLHLSSLDw----QHGFSVQp--- 131 Magnetospirillum m...
BAJ49683   41 LTVKVVARQFAWqfvypd-----------------------gtvsgELRVKAgqTVRLELNSEDv----IHSFYLRd--- 90  uncultured crenarc...
YP_344943  81 QQVDVSGHQWYWtm-------------------------------sTDTVVAgkPVEFRVIGADv----NHGFGVYnedl 125 Nitrosococcus ocea...
AAU91543   74 LQVRLVAGRYGFyp-------------------------------rEIEVPAgrRIVFRMASMDv----LHGAHIPm--- 115 Methylococcus caps...
Feature 1                                    #   #   #  #     
2OCC_B    168 -lGLKTDAIpg-rLNQTTLMSs-rPGLYYGQCSEICgSNHSFMPIVLE 212 cow
1EHK_B    121 -tNINVEVLpg-eVSTVRYTFk-rPGEYRIICNQYCgLGHQNMFGTIV 165 Thermus thermophilus
2YEV_E    169 -lAGKRDAIpg-qTTRISFEPk-ePGLYYGFCAELCgASHARMLFRVV 213 Thermus thermophilus HB8
2IWF_A    592 -hGVAMEVGpq-qTSSVTFVAa-nPGVYWYYCQWFChALHMEMRGRMF 636 Achromobacter cycloclastes
NP_378395 131 -hGPQNWNIvpgvNSYAFFYApmtPGNYTFHCAEYCgIGHSYMYGYLW 177 Sulfolobus tokodaii str. 7
NP_375982 124 dgVVQVNAVpg-tPSYIYFVTpptPGNFTWRDSEYSaYNFSYFTGTLE 170 Sulfolobus tokodaii str. 7
BAA82096  132 -aNINLQVHpg-iDEVVTITPt-dSGDFGIICNEYCgIGHHTMLGKIR 176 Magnetospirillum magnetotacticum
BAJ49683   91 -fGLKKDVVpg-rTNVLYVTPl-ePGTYLIQCAEFCgQGHYSMRANMV 135 uncultured crenarchaeote 10-H-08
YP_344943 126 elVAQVQAMpd-yTNKLIHTFd-ePGKYRIFCLEYCgLAHHVMMSELK 171 Nitrosococcus oceani ATCC 19707
AAU91543  116 -tNMSTMIVpg-yVSEVVSVFp-kPGEYPMLCNEYCgLGHDHMWSKVT 160 Methylococcus capsulatus str. Bath
1EHK_B    121 -tNINVEVLpg-eVSTVRYTFk-rPGEYRIICNQYCgLGHQNMFGTIV 165 Thermus thermophilus
2YEV_E    169 -lAGKRDAIpg-qTTRISFEPk-ePGLYYGFCAELCgASHARMLFRVV 213 Thermus thermophilus HB8
2IWF_A    592 -hGVAMEVGpq-qTSSVTFVAa-nPGVYWYYCQWFChALHMEMRGRMF 636 Achromobacter cycloclastes
NP_378395 131 -hGPQNWNIvpgvNSYAFFYApmtPGNYTFHCAEYCgIGHSYMYGYLW 177 Sulfolobus tokodaii str. 7
NP_375982 124 dgVVQVNAVpg-tPSYIYFVTpptPGNFTWRDSEYSaYNFSYFTGTLE 170 Sulfolobus tokodaii str. 7
BAA82096  132 -aNINLQVHpg-iDEVVTITPt-dSGDFGIICNEYCgIGHHTMLGKIR 176 Magnetospirillum magnetotacticum
BAJ49683   91 -fGLKKDVVpg-rTNVLYVTPl-ePGTYLIQCAEFCgQGHYSMRANMV 135 uncultured crenarchaeote 10-H-08
YP_344943 126 elVAQVQAMpd-yTNKLIHTFd-ePGKYRIFCLEYCgLAHHVMMSELK 171 Nitrosococcus oceani ATCC 19707
AAU91543  116 -tNMSTMIVpg-yVSEVVSVFp-kPGEYPMLCNEYCgLGHDHMWSKVT 160 Methylococcus capsulatus str. Bath

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