2OCC,1AR1


Conserved Protein Domain Family
CcO_II_C

?
cd13912: CcO_II_C 
Click on image for an interactive view with Cn3D
C-terminal domain of Cytochrome c Oxidase subunit II
Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.
Statistics
?
PSSM-Id: 259979
Aligned: 43 rows
Threshold Bit Score: 205.112
Threshold Setting Gi: 2914142
Created: 8-Jun-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: CuA binding site [ion binding site], 6 residue positions
Conserved feature residue pattern:H C E C H MClick to see conserved feature residue pattern help
Evidence:
  • Structure:2OCC; Bovine heart Cytochrome C Oxidase binds coppers at binuclear Cu center.
    View structure with Cn3D
  • Comment:CuA is a binuclear Cu center. It is believed that the electron is transferred from cytochrome C to CuA.
  • Citation:PMID 7652554
  • Citation:PMID 8638158

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2OCC_B        93 PSLTVKTMGHQWYWSYEYTDye----------dLSFDSYMIPtselk----------pgelRLLEVDNRVVLPMEMTIRM 152 cow
1AR1_B       139 PDLVIKAIGHQWYWSYEYPNd-----------gVAFDALMLEkealada------gysedeYLLATDNPVVVPVGKKVLV 201 Paracoccus deni...
Q9ZDC6       165 IDLTIKVVGYQWYWHYIYPDyd----------nLEFDSVMISdknlq----------igqkRLLDVDNRIVIPENTTVRF 224 Rickettsia prow...
AAK84264     108 PEITVKAIGNQWYWSFEYGDhvfdnengepketIAFDSFMVAeddle----------lgeqRNLAVDNYLVLPINTSIRM 177 Rhizophydium sp...
AAC61619      96 SELTLKVIGHQWYWSYEYGDsg----------kLCFDSFMKSlddls----------lgdfRLFDVDNRCVLPVGVNVGV 155 Onchocerca volv...
AAU92995     116 SDMTVKVTGYQWKWRYTYLDn-----------gIDFFSTLDAksnearqlgvrsnpeavpnYLLEVDKPLVIPAGKKVRF 184 Methylococcus c...
CAD13890     101 SDLTIKATGYQWKWGYDYLKgeg--------egISFLSTLATprdqidn-----lapksdtYLIEVDNELVVPVNRKVRI 167 Ralstonia solan...
NP_107795    167 AKLTVKATGNQWNWDYEYQTdn----------tLSFNSAILQdgdrakag---kedrkvypRLLAVDNELVVPVNTMTRV 233 Mesorhizobium l...
YP_003059414 157 DWVTIKTYGRQWYWSYFIDTenadg----evevVEFDARMIAeddips--------tpgarRNLSTDNPLVLPQGKYIRM 224 Hirschia baltic...
YP_003853852 233 PSVTIKAIGFQWGWSYVYPDfg----------dFEFDALMAPkdsv-----------psnlYRLATTNDVVVPAGETIRI 291 Parvularcula be...
1AR1_B       139 PDLVIKAIGHQWYWSYEYPNd-----------gVAFDALMLEkealada------gysedeYLLATDNPVVVPVGKKVLV 201 Paracoccus deni...
Q9ZDC6       165 IDLTIKVVGYQWYWHYIYPDyd----------nLEFDSVMISdknlq----------igqkRLLDVDNRIVIPENTTVRF 224 Rickettsia prow...
AAK84264     108 PEITVKAIGNQWYWSFEYGDhvfdnengepketIAFDSFMVAeddle----------lgeqRNLAVDNYLVLPINTSIRM 177 Rhizophydium sp...
AAC61619      96 SELTLKVIGHQWYWSYEYGDsg----------kLCFDSFMKSlddls----------lgdfRLFDVDNRCVLPVGVNVGV 155 Onchocerca volv...
AAU92995     116 SDMTVKVTGYQWKWRYTYLDn-----------gIDFFSTLDAksnearqlgvrsnpeavpnYLLEVDKPLVIPAGKKVRF 184 Methylococcus c...
CAD13890     101 SDLTIKATGYQWKWGYDYLKgeg--------egISFLSTLATprdqidn-----lapksdtYLIEVDNELVVPVNRKVRI 167 Ralstonia solan...
NP_107795    167 AKLTVKATGNQWNWDYEYQTdn----------tLSFNSAILQdgdrakag---kedrkvypRLLAVDNELVVPVNTMTRV 233 Mesorhizobium l...
YP_003059414 157 DWVTIKTYGRQWYWSYFIDTenadg----evevVEFDARMIAeddips--------tpgarRNLSTDNPLVLPQGKYIRM 224 Hirschia baltic...
YP_003853852 233 PSVTIKAIGFQWGWSYVYPDfg----------dFEFDALMAPkdsv-----------psnlYRLATTNDVVVPAGETIRI 291 Parvularcula be...
Feature 1                #                                  # # #   #  #               
2OCC_B       153 LVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSrPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKW 222 cow
1AR1_B       202 QVTATDVIHAWTIPAFAVKQDAVPGRIAQLWFSVDqEGVYFGQCSELCGINHAYMPIVVKAVSQEKYEAW 271 Paracoccus denitrificans
Q9ZDC6       225 LITAGDVIHSFAVPSLGFKIDAVPGRINETWTRVTkKGVYYGQCSELCGINHGFMPIAIEVVSKEDFNNW 294 Rickettsia prowazekii
AAK84264     178 LVTANDVIHSFSINSLGIKVDALPGRINALGFIINrPGQFYGQCSELCGSLHGFMPIGLKAVSLSSYLSF 247 Rhizophydium sp. 136
AAC61619     156 YCTSSDVIHSFAIPKCFIKMDALNGLLTKVTCSFScSGLFFGQCSEICGANHSFMPIVLELTSLECWKGW 225 Onchocerca volvulus
AAU92995     185 LFTAADVIHSWWVPQFGWKKDAIPGYVTDAWTRVEqPGIYRGQCAELCGRDHGFMPIVVDVKSEADYNKW 254 Methylococcus capsulatus ...
CAD13890     168 VTTANDVIHSWMIPAFGVKQDAIPGFVRDTWFKAEkVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSW 237 Ralstonia solanacearum
NP_107795    234 LVTATDVIHSFAMPSFGIKIDAIPGRTNETWFKAEkEGLYYGQCSQLCGKDHAFMPIAIRVVSDAQFKTW 303 Mesorhizobium loti MAFF30...
YP_003059414 225 NLAASDVIHSWAMPAFRLKTDAVPGRLNQLWFKAEkLGVYYGQCSELCGRDHAFMPIEMRIVPQDQYDQW 294 Hirschia baltica ATCC 49814
YP_003853852 292 ATVGRDVIHSWAMPAFGIKIDAIPGRYNETWFYTEnEGTYYGQCSEMCGLDHAFMPISVRVVSRPEFEAW 361 Parvularcula bermudensis ...
1AR1_B       202 QVTATDVIHAWTIPAFAVKQDAVPGRIAQLWFSVDqEGVYFGQCSELCGINHAYMPIVVKAVSQEKYEAW 271 Paracoccus denitrificans
Q9ZDC6       225 LITAGDVIHSFAVPSLGFKIDAVPGRINETWTRVTkKGVYYGQCSELCGINHGFMPIAIEVVSKEDFNNW 294 Rickettsia prowazekii
AAK84264     178 LVTANDVIHSFSINSLGIKVDALPGRINALGFIINrPGQFYGQCSELCGSLHGFMPIGLKAVSLSSYLSF 247 Rhizophydium sp. 136
AAC61619     156 YCTSSDVIHSFAIPKCFIKMDALNGLLTKVTCSFScSGLFFGQCSEICGANHSFMPIVLELTSLECWKGW 225 Onchocerca volvulus
AAU92995     185 LFTAADVIHSWWVPQFGWKKDAIPGYVTDAWTRVEqPGIYRGQCAELCGRDHGFMPIVVDVKSEADYNKW 254 Methylococcus capsulatus ...
CAD13890     168 VTTANDVIHSWMIPAFGVKQDAIPGFVRDTWFKAEkVGVYRGQCAELCGKEHAFMPIVVRVVSDADYTSW 237 Ralstonia solanacearum
NP_107795    234 LVTATDVIHSFAMPSFGIKIDAIPGRTNETWFKAEkEGLYYGQCSQLCGKDHAFMPIAIRVVSDAQFKTW 303 Mesorhizobium loti MAFF30...
YP_003059414 225 NLAASDVIHSWAMPAFRLKTDAVPGRLNQLWFKAEkLGVYYGQCSELCGRDHAFMPIEMRIVPQDQYDQW 294 Hirschia baltica ATCC 49814
YP_003853852 292 ATVGRDVIHSWAMPAFGIKIDAIPGRYNETWFYTEnEGTYYGQCSEMCGLDHAFMPISVRVVSRPEFEAW 361 Parvularcula bermudensis ...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap